Aspartate aminotransferase, cytoplasmic

Gene:

GOT1 Enzyme: EC 2.6.1.1 This enzyme has known catalytic activity involved in reaction: 3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate

Organism:

Homo sapiens (Human)

Uniprot:

P17174go to UniProt

Biological function:

Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, ... [show more]go to UniProt

Representative structure for UniProt P17174

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PDB 3wzf chain A (observed residues)
PDB 3wzf chain A (observed residues)

PDB chain shown: 3wzf A go to PDBe

UniProt residues 2 - 413

Coverage: 100%

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Similarity

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17
Publications

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