Disintegrin metalloproteinase/disintegrin echistatin

Organism:

Echis carinatus sochureki (Saw-scaled viper)

Uniprot:
Biological function:

Potent inhibitor of ligand binding to the integrins alpha-V/beta-3 (ITGAV/ITGB3) (IC(50)=20.7 nM), alpha-IIb/beta-3 (ITGA2B/ITGB3) (IC(50)=51.5 nM), alpha-5/beta-1 (ITGA5/ITGB1) (IC(50)=132.6 nM), and moderate inhibitor of ligand binding to the integrin alpha-V/beta-5 (ITGAV/ITGB5) (IC(50)=286.4 nM) (PubMed:33182321, PubMed:9269775). Competition with fibrinogen for the RGD recognition sites on the alpha-IIb/beta-3 integrin (glyco-protein IIb/IIIa complex) results in the inhibition ... [show more]go to UniProt


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PDB 2ech chain A (observed residues)
PDB 2ech chain A (observed residues)

PDB chain shown: 2ech A go to PDBe

UniProt residues 131 - 179

Coverage: 26%

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3
Structures

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1
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26
Publications

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Processed Proteins (3):

Protein Name
Representative Structures
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Available Structural Data
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Snake venom metalloproteinase
 0 Number of PDB structures
 0 Number of ligands
 0 Number of interaction partners
Disintegrin echistatin-alpha-2
UniProt range of the processed protein: 131 - 177
UniProt range of representative PDB 6lsq chain A: 131 - 175
 0 Number of PDB structures
 0 Number of ligands
 0 Number of interaction partners
Disintegrin echistatin
UniProt range of the processed protein: 131 - 179
UniProt range of representative PDB 2ech chain A: 131 - 179
 3 Number of PDB structures
 1 Number of ligands
 0 Number of interaction partners