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Disintegrin metalloproteinase/disintegrin echistatin
Echis carinatus sochureki (Saw-scaled viper)
P17347go to UniProt
Potent inhibitor of ligand binding to the integrins alpha-V/beta-3 (ITGAV/ITGB3) (IC(50)=20.7 nM), alpha-IIb/beta-3 (ITGA2B/ITGB3) (IC(50)=51.5 nM), alpha-5/beta-1 (ITGA5/ITGB1) (IC(50)=132.6 nM), and moderate inhibitor of ligand binding to the integrin alpha-V/beta-5 (ITGAV/ITGB5) (IC(50)=286.4 nM) (PubMed:33182321, PubMed:9269775). Competition with fibrinogen for the RGD recognition sites on the alpha-IIb/beta-3 integrin (glyco-protein IIb/IIIa complex) results in the inhibition ... [show more]go to UniProt
Representative structure for UniProt P17347
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PDB chain shown: 2ech A go to PDBe
UniProt residues 131 - 179
Coverage: 26%
Processed Proteins (3):
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UniProt range of representative PDB 6lsq chain A: 131 - 175
UniProt range of representative PDB 2ech chain A: 131 - 179