Neurofibromin

Gene:

NF1 Disease Neurofibromatosis 1: A disease characterized by patches of skin pigmentation (cafe-au-lait spots), Lisch nodules of the iris, tumors in the peripheral nervous system and fibromatous skin tumors. Individuals with the disorder have increased susceptibility to the development of benign and malignant tumors... [click for more]

Organism:

Homo sapiens (Human)

Uniprot:

P21359go to UniProt

Biological function:

Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activitygo to UniProt

Representative structure for UniProt P21359

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PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)
PDB 8e20 chain B (observed residues)

PDB chain shown: 8e20 B go to PDBe

UniProt residues 1 - 2839

Coverage: 79%

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26
Structures

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15
Ligands

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3
Interactions

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393
Similarity

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184
Publications

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