Aggregated Views of Proteins
Neurofibromin (P21359)
Annotations
This section shows residue-level functional annotations available for the PDB entries related to this protein. These annotations are contributed by members of the PDBe-KB consortium or generated by weekly data pipelines. For more information see the PDBe-KB Wiki pages.
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Annotated Residues
The visualisation is using UniProt numbering for residues, not PDB numbering.
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| Curated interface annotations | |
| Predicted functional sites | |
| Predicted PTM sites | |
| Predicted protein binding sites | |
| Predicted ligand binding sites | |
| Molecular channels | |
| Biophysical parameters | |
| Domains | |
| Ligand binding sites | |
| Interaction interfaces | |
Curated interface annotations
3D Complex is a hierarchical classification of protein complexes that describes similarities in structure, sequence, as well as topology of contacts of the constituent proteins
Predicted functional sites
CATH-FunSites are groups of amino acid residues that are evolutionarily conserved within a CATH FunFam
Predicted PTM sites
Predictions of phosphorylation sites for kinases in target proteins
A Comprehensive Resource of Human Phosphosites within Their Full Context
Predicted protein binding sites
14-3-3-Pred is a webserver that predicts 14-3-3-binding sites in proteins
Predicted ligand binding sites
P2Rank is a new open source software package for ligand binding site prediction from protein structure
canSAR is an integrated knowledge-base to provide drug-discovery useful predictions
Molecular channels
ChannelsDB is a database providing information about the positions, geometry and physicochemical properties of channels (pores and tunnels) found within biomacromolecular structures deposited in the Protein Data Bank
Biophysical parameters
POPSCOMP is a method to analyse interactions between individual complex components of proteins and/or nucleic acids by calculating the solvent accessible surface area (SASA) buried upon complex formation.
POPSCOMP is a method to analyse interactions between individual complex components of proteins and/or nucleic acids by calculating the solvent accessible surface area (SASA) buried upon complex formation.
POPSCOMP is a method to analyse interactions between individual complex components of proteins and/or nucleic acids by calculating the solvent accessible surface area (SASA) buried upon complex formation.
3D Complex is a hierarchical classification of protein complexes that describes similarities in structure, sequence, as well as topology of contacts of the constituent proteins
3D Complex is a hierarchical classification of protein complexes that describes similarities in structure, sequence, as well as topology of contacts of the constituent proteins
Cospi-Depth is a server for computing/predicting depth, cavity sizes, ligand binding sites and pKa
Cospi-Depth is a server for computing/predicting depth, cavity sizes, ligand binding sites and pKa
Domains
Residues mapped to InterPro domains
Ligand binding sites
Residues binding OXTOXYNOL-10<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/OXN_200.svg" /><span>
Residues binding IMIDAZOLE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/IMD_200.svg" /><span>
Residues binding 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/GSP_200.svg" /><span>
Residues binding 2-(N-MORPHOLINO)-ETHANESULFONIC ACID<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/MES_200.svg" /><span>
Residues binding GLYCEROL<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/GOL_200.svg" /><span>
Residues binding SULFATE ION<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/SO4_200.svg" /><span>
Residues binding FORMIC ACID<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/FMT_200.svg" /><span>
Residues binding MAGNESIUM ION<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/MG_200.svg" /><span>
Residues binding SODIUM ION<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/NA_200.svg" /><span>
Residues binding ZINC ION<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/ZN_200.svg" /><span>
Residues binding PYROPHOSPHATE 2-<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/POP_200.svg" /><span>
Residues binding PHOSPHATIDYLETHANOLAMINE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/PTY_200.svg" /><span>
Residues binding (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/PEV_200.svg" /><span>
Interaction interfaces
Residues interacting with Neurofibromin (self) (P21359)
Residues interacting with GTPase KRas (P01116)
Residues interacting with Sprouty-related, EVH1 domain-containing protein 1 (Q7Z699)
Sequence conservation
Amino acid probabilities
The amino acid probabilities are calculated using HMM profiles based on multiple sequence alignments. Click to see more details...
Data displayed by
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Amino acid properties
Aromatic
Polar
Hydrophobic
Negative charge
Proline
Positive charge
Cysteine
Glycine
Variants
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Annotations :
Predicted annotations
Curated annotations
Domains :
InterPro annotations