Proteasome subunit beta type-10

Gene:

PSMB10 Enzyme: EC 3.4.25.1 This enzyme has known catalytic activity involved in reaction: Cleavage of peptide bonds with very broad specificity. Disease Proteasome-associated autoinflammatory syndrome 5: An autosomal recessive, autoinflammatory disorder characterized by recurrent, polymorphic disseminated cutaneous rash with annular lesions, non-specific lymphocytic infiltration in the skin, fever, failure to thrive, and persistent hepatosplenomegaly. Disease onset is in early infancy... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

LMP10, MECL1

Uniprot:

P40306go to UniProt

Biological function:

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptidesgo to UniProt

Representative structure for UniProt P40306

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PDB 6e5b chain V (observed residues)
PDB 6e5b chain V (observed residues)
PDB 6e5b chain V (observed residues)
PDB 6e5b chain V (observed residues)

PDB chain shown: 6e5b V go to PDBe

UniProt residues 1 - 273

Coverage: 80%

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16
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31
Similarity

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