Excitatory amino acid transporter 2

Gene:

SLC1A2 Enzyme: EC undefined This enzyme has known catalytic activity involved in reaction: D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in) Disease Developmental and epileptic encephalopathy 41: A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

EAAT2, GLT1

Uniprot:

P43004go to UniProt

Biological function:

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ... [show more]go to UniProt

Representative structure for UniProt P43004

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PDB 7xr4 chain A (observed residues)
PDB 7xr4 chain A (observed residues)
PDB 7xr4 chain A (observed residues)
PDB 7xr4 chain A (observed residues)
PDB 7xr4 chain A (observed residues)
PDB 7xr4 chain A (observed residues)

PDB chain shown: 7xr4 A go to PDBe

UniProt residues 1 - 574

Coverage: 74%

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Similarity

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