Phosphatidylserine synthase 1

Gene:

PTDSS1 Enzyme: EC 2.7.8.29 This enzyme has known catalytic activity involved in reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline Disease Lenz-Majewski hyperostotic dwarfism: A syndrome of intellectual disability and multiple congenital anomalies that features generalized craniotubular hyperostosis. LMHD is characterized by the combination of sclerosing bone dysplasia, intellectual disability and distinct craniofacial, dental, cutaneous and distal limb anomalies... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

KIAA0024, PSSA

Uniprot:

P48651go to UniProt

Biological function:

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:19014349, PubMed:24241535). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:19014349, PubMed:24241535) [show more]go to UniProt

Representative structure for UniProt P48651

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PDB 9b4e chain A (observed residues)
PDB 9b4e chain A (observed residues)
PDB 9b4e chain A (observed residues)
PDB 9b4e chain A (observed residues)

PDB chain shown: 9b4e A go to PDBe

UniProt residues 1 - 409

Coverage: 82%

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3
Structures

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6
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16
Publications

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