Thimet oligopeptidase

Gene:

THOP1 Enzyme: EC 3.4.24.15 This enzyme has known catalytic activity involved in reaction: Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.

Organism:

Homo sapiens (Human)

Uniprot:

P52888go to UniProt

Biological function:

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist ... [show more]go to UniProt

Representative structure for UniProt P52888

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PDB 2o36 chain A (observed residues)
PDB 2o36 chain A (observed residues)

PDB chain shown: 2o36 A go to PDBe

UniProt residues 16 - 689

Coverage: 95%

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2
Structures

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Ligands

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41
Similarity

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26
Publications

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