Ubiquitin-conjugating enzyme E2 K

Gene:

UBE2K Enzyme: EC 2.3.2.23 This enzyme has known catalytic activity involved in reaction: S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Organism:

Homo sapiens (Human)

Synonyms:

HIP2, LIG

Uniprot:

P61086go to UniProt

Biological function:

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic ... [show more]go to UniProt

Representative structure for UniProt P61086

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PDB 6jb6 chain B (observed residues)
PDB 6jb6 chain B (observed residues)

PDB chain shown: 6jb6 B go to PDBe

UniProt residues 1 - 200

Coverage: 100%

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Structures

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134
Similarity

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