Dethiobiotin synthetase BioD

Gene:

bioD Enzyme: EC 6.3.3.3 This enzyme has known catalytic activity involved in reaction: (7R,8S)-7,8-diammoniononanoate + CO2 + ATP = (4R,5S)-dethiobiotin + ADP + phosphate + 3 H(+)

Organism:

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Uniprot:

P9WPQ5go to UniProt

Biological function:

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring (PubMed:20565114). Can use a range of NTPs; has highest affinity for CTP (KD is measured as 17.2 uM or 0.160 uM in 2 different papers) while KD for ... [show more]go to UniProt

Representative structure for UniProt P9WPQ5

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PDB 3fmi chain C (observed residues)
PDB 3fmi chain C (observed residues)

PDB chain shown: 3fmi C go to PDBe

UniProt residues 1 - 226

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