Histone acetyltransferase p300

Gene:

EP300 Enzyme: EC 2.3.1.48 This enzyme has known catalytic activity involved in reaction: (S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L-lysyl-[protein] + CoA + H(+) Disease Rubinstein-Taybi syndrome 2: A disorder characterized by craniofacial abnormalities, postnatal growth deficiency, broad thumbs, broad big toes, intellectual disability and a propensity for development of malignancies. Some individuals with RSTS2 have less severe mental impairment, more severe microcephaly, and a greater degree of changes in facial bone structure than RSTS1 patients... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

P300

Uniprot:

Q09472go to UniProt

Biological function:

(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A proteingo to UniProt

Representative structures for UniProt Q09472

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PDB 1l3e chain B (observed residues)
PDB 1l3e chain B (observed residues)
PDB 9jej chain C (observed residues)
PDB 9jej chain C (observed residues)
PDB 9jej chain C (observed residues)
PDB 9jej chain C (observed residues)
PDB 7w9v chain K (observed residues)
PDB 7w9v chain K (observed residues)
PDB 7w9v chain K (observed residues)
PDB 7w9v chain K (observed residues)
PDB 7w9v chain K (observed residues)
PDB 7w9v chain K (observed residues)
PDB 3io2 chain A (observed residues)
PDB 3io2 chain A (observed residues)

PDB chain shown: 1l3e B go to PDBe

UniProt residues 323 - 423

Coverage: 4%

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57
Structures

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45
Ligands

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19
Similarity

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822
Publications

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