Cleavage and polyadenylation specificity factor subunit 1

Gene:

CPSF1 Disease Myopia 27, autosomal dominant: A form of myopia, a refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. MYP27 patients are affected by early-onset high myopia with increased axial lengths... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

CPSF160

Uniprot:

Q10570go to UniProt

Biological function:

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role ... [show more]go to UniProt

Representative structure for UniProt Q10570

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PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)
PDB 6fuw chain A (observed residues)

PDB chain shown: 6fuw A go to PDBe

UniProt residues 1 - 1443

Coverage: 82%

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10
Structures

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1
Ligands

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0
Similarity


51
Publications

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