Glutamate receptor ionotropic, NMDA 2B

Gene:

GRIN2B Enzyme: EC undefined This enzyme has known catalytic activity involved in reaction: K(+)(in) = K(+)(out) Disease Intellectual developmental disorder, autosomal dominant 6, with or without seizures: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD6 additional features may include seizures, hypotonia, abnormal movements, such as dystonia, and autistic features... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

NMDAR2B

Uniprot:

Q13224go to UniProt

Biological function:

Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). Participates in ... [show more]go to UniProt

Representative structures for UniProt Q13224

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PDB 9iyq chain D (observed residues)
PDB 9iyq chain D (observed residues)
PDB 9iyq chain D (observed residues)
PDB 9iyq chain D (observed residues)
PDB 9iyq chain D (observed residues)
PDB 9iyq chain D (observed residues)
PDB 9iyq chain D (observed residues)
PDB 9iyq chain D (observed residues)
PDB 7ujt chain B (observed residues)
PDB 7ujt chain B (observed residues)

PDB chain shown: 9iyq D go to PDBe

UniProt residues 1 - 842

Coverage: 52%

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17
Structures

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17
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5
Similarity

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65
Publications

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