- Display observed secondary structure variance per amino acid residue
Chromodomain-helicase-DNA-binding protein 4
CHD4 Enzyme: EC 3.6.4.12 This enzyme has known catalytic activity involved in reaction: ATP + H2O = ADP + H(+) + phosphate Disease Sifrim-Hitz-Weiss syndrome: An autosomal dominant syndrome characterized by intellectual disability, variable congenital defects affecting cardiac, skeletal, and urogenital systems. Short stature, macrocephaly, hearing impairment, and facial dysmorphism are present in some patients... [click for more]
Homo sapiens (Human)
Q14839go to UniProt
ATP-dependent helicase that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote ... [show more]go to UniProt
Representative structure for UniProt Q14839
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PDB chain shown: 6ryu L go to PDBe
UniProt residues 1 - 1912
Coverage: 36%