Tryptophan dimethylallyltransferase

Gene:

dmaW Enzyme: EC 2.5.1.34 This enzyme has known catalytic activity involved in reaction: L-tryptophan + dimethylallyl diphosphate = 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate

Organism:

Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)

Synonyms:

fgaPT2

Uniprot:

Q50EL0go to UniProt

Biological function:

Tryptophan dimethylallyltransferase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid (PubMed:15933009, PubMed:23435153, PubMed:26972831). DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:15870460, PubMed:23435153). The second step ... [show more]go to UniProt

Representative structure for UniProt Q50EL0

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PDB 3i4z chain B (observed residues)
PDB 3i4z chain B (observed residues)

PDB chain shown: 3i4z B go to PDBe

UniProt residues 1 - 459

Coverage: 92%

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