Lysosomal cholesterol signaling protein

Gene:

GPR155

Organism:

Homo sapiens (Human)

Synonyms:

PGR22

Uniprot:

Q7Z3F1go to UniProt

Biological function:

Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (PubMed:36007018). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disrupt interaction between the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:36007018). Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the ... [show more]go to UniProt

Representative structure for UniProt Q7Z3F1

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PDB 8u5v chain A (observed residues)
PDB 8u5v chain A (observed residues)
PDB 8u5v chain A (observed residues)
PDB 8u5v chain A (observed residues)
PDB 8u5v chain A (observed residues)
PDB 8u5v chain A (observed residues)
PDB 8u5v chain A (observed residues)
PDB 8u5v chain A (observed residues)
PDB 8u5v chain A (observed residues)
PDB 8u5v chain A (observed residues)

PDB chain shown: 8u5v A go to PDBe

UniProt residues 1 - 870

Coverage: 64%

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11
Structures

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11
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11
Publications

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