Notch-regulated ankyrin repeat-containing protein

Gene:

NRARP

Organism:

Homo sapiens (Human)

Uniprot:

Q7Z6K4go to UniProt

Biological function:

Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved ... [show more]go to UniProt

Representative structure for UniProt Q7Z6K4

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PDB 6py8 chain B (observed residues)
PDB 6py8 chain B (observed residues)
PDB 6py8 chain B (observed residues)
PDB 6py8 chain B (observed residues)

PDB chain shown: 6py8 B go to PDBe

UniProt residues 1 - 114

Coverage: 74%

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