tRNA-splicing endonuclease subunit Sen2

Gene:

TSEN2 Enzyme: EC 4.6.1.16 This enzyme has known catalytic activity involved in reaction: pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus. Disease Pontocerebellar hypoplasia 2B: A disorder characterized by an abnormally small cerebellum and brainstem, and progressive microcephaly from birth combined with extrapyramidal dyskinesia. Severe chorea occurs and epilepsy is frequent... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

SEN2

Uniprot:

Q8NCE0go to UniProt

Biological function:

Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the ... [show more]go to UniProt

Representative structure for UniProt Q8NCE0

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PDB 8hmy chain A (observed residues)
PDB 8hmy chain A (observed residues)
PDB 8hmy chain A (observed residues)
PDB 8hmy chain A (observed residues)
PDB 8hmy chain A (observed residues)
PDB 8hmy chain A (observed residues)

PDB chain shown: 8hmy A go to PDBe

UniProt residues 1 - 465

Coverage: 68%

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5
Structures

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1
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0
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16
Publications

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