Phosphoinositide 3-kinase regulatory subunit 4

Gene:

PIK3R4 Enzyme: EC 2.7.11.1 This enzyme has known catalytic activity involved in reaction: L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)

Organism:

Homo sapiens (Human)

Synonyms:

VPS15

Uniprot:

Q99570go to UniProt

Biological function:

Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123) [show more]go to UniProt

Representative structure for UniProt Q99570

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PDB 7bl1 chain C (observed residues)
PDB 7bl1 chain C (observed residues)
PDB 7bl1 chain C (observed residues)
PDB 7bl1 chain C (observed residues)
PDB 7bl1 chain C (observed residues)
PDB 7bl1 chain C (observed residues)
PDB 7bl1 chain C (observed residues)
PDB 7bl1 chain C (observed residues)

PDB chain shown: 7bl1 C go to PDBe

UniProt residues 1 - 1358

Coverage: 88%

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6
Structures

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4
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5
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194
Similarity

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18
Publications

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