DNA polymerase alpha catalytic subunit

Gene:

pola1 Enzyme: EC 2.7.7.7 This enzyme has known catalytic activity involved in reaction: DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate

Organism:

Xenopus laevis (African clawed frog)

Synonyms:

pola

Uniprot:

Q9DE46go to UniProt

Biological function:

Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the ... [show more]go to UniProt

Representative structure for UniProt Q9DE46

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PDB 8v5o chain A (observed residues)
PDB 8v5o chain A (observed residues)

PDB chain shown: 8v5o A go to PDBe

UniProt residues 335 - 1458

Coverage: 12%

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15
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4
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3
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