Ketol-acid reductoisomerase (NADP(+))

Organism:

Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

Uniprot:
Biological function:

Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovaleratego to UniProt


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PDB 1np3 chain B (observed residues)
PDB 1np3 chain B (observed residues)

PDB chain shown: 1np3 B go to PDBe

UniProt residues 1 - 338

Coverage: 97%

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