CRISPR-associated endonuclease Cas12a

Gene:

cas12a Enzyme: EC 3.1.21.1 This enzyme has known catalytic activity involved in reaction: RNA = a 5'-hydroxy-ribonucleotide + n nucleoside-2',3'-cyclophosphates.

Organism:

Acidaminococcus sp. (strain BV3L6)

Synonyms:

cpf1

Uniprot:

U2UMQ6go to UniProt

Biological function:

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Recognizes a short motif in the CRISPR repeat sequences (the 5' ... [show more]go to UniProt

Representative structure for UniProt U2UMQ6

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PDB 8sfo chain A (observed residues)
PDB 8sfo chain A (observed residues)
PDB 8sfo chain A (observed residues)
PDB 8sfo chain A (observed residues)
PDB 8sfo chain A (observed residues)
PDB 8sfo chain A (observed residues)

PDB chain shown: 8sfo A go to PDBe

UniProt residues 1 - 1307

Coverage: 95%

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16
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143
Publications

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