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Cystine-knot cytokines
superfamily
Cystine-knot cytokines
SCOP ID
: 3000846
Show ancestry
%0
1000004
class 1000004
Small proteins
2000537
fold 2000537
Cystine-knot cytokines
1000004->2000537
3000846
superfamily 3000846
Cystine-knot cytokines
2000537->3000846
Families
[ 9 entries ]
Noggin
SCOP ID 4003414
Platelet-derived growth factor-like
SCOP ID 4003427
Transforming growth factor (TGF)-beta
SCOP ID 4003433
Neurotrophin
SCOP ID 4003445
Gonadodropin/Follitropin
SCOP ID 4003451
Coagulogen
SCOP ID 4003452
Interleukin 17F, IL-17F
SCOP ID 4003639
Spatzle-like
SCOP ID 4004165
PF16077 CL0079; Spätzle
Sclerostin-like
SCOP ID 4005526
PF05463 CL0079
Domains
[ 50 entries ]
ID
Region
Links
Protein
Vascular endothelial growth factor A
Species
Homo sapiens
P15692
39-133
UniProt
Representative domain 8038748
Represented structures [ 118 ]
1FLT
V:13-107
PDBe
RCSB PDB
Protein
Interleukin-17A
Species
Homo sapiens
Q16552
72-153
UniProt
Representative domain 8088224
Represented structures [ 36 ]
5N92
A:72-153
PDBe
RCSB PDB
Protein
Bone morphogenetic protein 2
Species
Homo sapiens
P12643
294-396
UniProt
Representative domain 8042164
Represented structures [ 33 ]
2H62
A:12-114
PDBe
RCSB PDB
Protein
Inhibin beta A chain
Species
Homo sapiens
P08476
311-426
UniProt
Representative domain 8037309
Represented structures [ 27 ]
2ARV
A:1-116
PDBe
RCSB PDB
Protein
Transforming growth factor beta-1 proprotein
Species
Homo sapiens
P01137
279-390
UniProt
Representative domain 8038779
Represented structures [ 22 ]
1KLD
A:1-112
PDBe
RCSB PDB
Protein
Growth/differentiation factor 2
Species
Homo sapiens
Q9UK05
325-429
UniProt
Representative domain 8070319
Represented structures [ 21 ]
4FAO
A:6-110
PDBe
RCSB PDB
Protein
Growth/differentiation factor 5
Species
Homo sapiens
P43026
397-501
UniProt
Representative domain 8070313
Represented structures [ 19 ]
2BHK
A:15-119
PDBe
RCSB PDB
Protein
Glycoprotein hormones alpha chain
Species
Homo sapiens
P01215
29-113
UniProt
Representative domain 8038799
Represented structures [ 18 ]
1HCN
A:5-89
PDBe
RCSB PDB
Protein
Beta-nerve growth factor
Species
Mus musculus
P01139
131-237
UniProt
Representative domain 8038790
Represented structures [ 17 ]
1BET
A:10-116
PDBe
RCSB PDB
Protein
Neurturin
Species
Homo sapiens
Q99748
100-197
UniProt
Representative domain 8084510
Represented structures [ 17 ]
5MR4
A:100-197
PDBe
RCSB PDB
Protein
Interleukin-17F
Species
Homo sapiens
Q96PD4
80-158
UniProt
Representative domain 8037216
Represented structures [ 16 ]
1JPY
A:50-128
PDBe
RCSB PDB
Protein
Beta-nerve growth factor
Species
Homo sapiens
P01138
123-236
UniProt
Representative domain 8038796
Represented structures [ 16 ]
1WWW
V:2-115
PDBe
RCSB PDB
Protein
Transforming growth factor beta-2 proprotein
Species
Homo sapiens
P61812
303-414
UniProt
Representative domain 8038776
Represented structures [ 14 ]
2TGI
A:1-112
PDBe
RCSB PDB
Protein
Artemin
Species
Homo sapiens
Q5T4W7
120-220
UniProt
Representative domain 8084512
Represented structures [ 12 ]
2ASK
A:13-113
PDBe
RCSB PDB
Protein
Bone morphogenetic protein 10
Species
Homo sapiens
O95393
321-424
UniProt
Representative domain 8094074
Represented structures [ 12 ]
6SF3
B:321-424
PDBe
RCSB PDB
Protein
Growth/differentiation factor 8
Species
Homo sapiens
O14793
268-375
UniProt
Representative domain 8070309
Represented structures [ 11 ]
5F3H
I:2-109
PDBe
RCSB PDB
Protein
Platelet-derived growth factor subunit B
Species
Homo sapiens
P01127
90-185
UniProt
Representative domain 8038746
Represented structures [ 10 ]
1PDG
A:9-104
PDBe
RCSB PDB
Protein
Follitropin subunit beta
Species
Homo sapiens
P01225
21-125
UniProt
Representative domain 8032460
Represented structures [ 9 ]
1XWD
B:3-107
PDBe
RCSB PDB
Protein
Transforming growth factor beta-3 proprotein
Species
Homo sapiens
P10600
301-412
UniProt
Representative domain 8038775
Represented structures [ 7 ]
1TGJ
A:1-112
PDBe
RCSB PDB
Protein
Protein spaetzle
Species
Drosophila melanogaster
P48607
225-326
UniProt
Representative domain 8053435
Represented structures [ 7 ]
4LXR
J:5-106
PDBe
RCSB PDB
Protein
Bone morphogenetic protein 6
Species
Homo sapiens
P22004
406-513
UniProt
Representative domain 8070311
Represented structures [ 7 ]
2R53
A:26-132
PDBe
RCSB PDB
Protein
Transforming growth factor beta-1 proprotein
Species
Sus scrofa
P07200
279-390
UniProt
Representative domain 8089960
Represented structures [ 7 ]
3RJR
B:250-361
PDBe
RCSB PDB
Protein
Glial cell line-derived neurotrophic factor
Species
Homo sapiens
P39905
109-211
UniProt
Representative domain 8084508
Represented structures [ 6 ]
3FUB
D:32-134
PDBe
RCSB PDB
Protein
Growth/differentiation factor 11
Species
Homo sapiens
O95390
300-407
UniProt
Representative domain 8089948
Represented structures [ 6 ]
5E4G
A:2-109
PDBe
RCSB PDB
Protein
Choriogonadotropin subunit beta 3
Species
Homo sapiens
P0DN86
22-131
UniProt
Representative domain 8038800
Represented structures [ 5 ]
1HCN
B:2-111
PDBe
RCSB PDB
Protein
Vascular endothelial growth factor C
Species
Homo sapiens
P49767
116-213
UniProt
Representative domain 8070295
Represented structures [ 5 ]
2X1W
A:116-213
PDBe
RCSB PDB
Protein
Vascular endothelial growth factor B
Species
Homo sapiens
P49765
34-129
UniProt
Representative domain 8070297
Represented structures [ 5 ]
2C7W
A:13-108
PDBe
RCSB PDB
Protein
Growth/differentiation factor 15
Species
Homo sapiens
Q99988
201-308
UniProt
Representative domain 8070315
Represented structures [ 5 ]
5VT2
A:5-112
PDBe
RCSB PDB
Protein
Neurotrophin-4
Species
Homo sapiens
P34130
81-207
UniProt
Representative domain 8036419
Represented structures [ 4 ]
1HCF
A:1-127
PDBe
RCSB PDB
Protein
Neurotrophin-3
Species
Homo sapiens
P20783
146-253
UniProt
Representative domain 8038795
Represented structures [ 4 ]
1NT3
A:8-115
PDBe
RCSB PDB
Protein
Vascular endothelial growth factor homolog
Species
Orf virus (strain NZ2)
P52584
24-116
UniProt
Representative domain 8070301
Represented structures [ 4 ]
2GNN
D:14-106
PDBe
RCSB PDB
Protein
Transforming growth factor beta-2 proprotein
Species
Mus musculus
P27090
303-414
UniProt
Representative domain 8070305
Represented structures [ 4 ]
5TX2
A:1-112
PDBe
RCSB PDB
Protein
Growth/differentiation factor 8
Species
Mus musculus
O08689
268-376
UniProt
Representative domain 8070307
Represented structures [ 4 ]
3HH2
A:1-109
PDBe
RCSB PDB
Protein
Placenta growth factor
Species
Homo sapiens
P49763
35-134
UniProt
Representative domain 8032496
Represented structures [ 3 ]
1FZV
A:18-117
PDBe
RCSB PDB
Protein
Bone morphogenetic protein 7
Species
Homo sapiens
P18075
328-431
UniProt
Representative domain 8032606
Represented structures [ 3 ]
1LXI
A:36-139
PDBe
RCSB PDB
Protein
Glial cell line-derived neurotrophic factor
Species
Rattus norvegicus
Q07731
114-211
UniProt
Representative domain 8038788
Represented structures [ 3 ]
1AGQ
B:38-135
PDBe
RCSB PDB
Protein
Glial cell line-derived neurotrophic factor
Species
Danio rerio
Q98TU0
138-235
UniProt
Representative domain 8102212
Represented structures [ 2 ]
7AML
C:138-235
PDBe
RCSB PDB
Protein
Sclerostin
Species
Homo sapiens
Q9BQB4
78-177
UniProt
Representative domain 8106455
Represented structures [ 2 ]
6L6R
C:78-177
PDBe
RCSB PDB
Protein
Brain-derived neurotrophic factor
Species
Homo sapiens
P23560
136-244
UniProt
Representative domain 8038793
Represented structures [ 1 ]
1BND
A:8-116
PDBe
RCSB PDB
Protein
Coagulogen
Species
Tachypleus tridentatus
P02681
21-195
UniProt
Representative domain 8038805
Represented structures [ 1 ]
1AOC
A:1-175
PDBe
RCSB PDB
Protein
Noggin
Species
Homo sapiens
Q13253
28-232
UniProt
Representative domain 8043287
Represented structures [ 1 ]
1M4U
A:28-232
PDBe
RCSB PDB
Protein
Snake venom vascular endothelial growth factor toxin VR-1
Species
Daboia russelii
P67861
25-119
UniProt
Representative domain 8043681
Represented structures [ 1 ]
1WQ9
A:1-95
PDBe
RCSB PDB
Protein
Bone morphogenetic protein 3
Species
Homo sapiens
P12645
366-472
UniProt
Representative domain 8070317
Represented structures [ 1 ]
2QCQ
A:4-110
PDBe
RCSB PDB
Protein
Ovulation-inducing factor (OIF)
Species
Lama glama
J9PBR9
9-116
UniProt
Representative domain 8070321
Represented structures [ 1 ]
4EFV
A:9-116
PDBe
RCSB PDB
Protein
Venom nerve growth factor
Species
Naja atra
P61898
9-116
UniProt
Representative domain 8070323
Represented structures [ 1 ]
4EC7
A:9-116
PDBe
RCSB PDB
Protein
Lutropin subunit beta
Species
Bos taurus
P04651
21-138
UniProt
Representative domain 8094811
Represented structures [ 1 ]
6P57
B:1-118
PDBe
RCSB PDB
Protein
Snake venom vascular endothelial growth factor toxin vammin
Species
Vipera ammodytes ammodytes
P67863
25-124
UniProt
Representative domain 8043680
1WQ8
A:1-100
PDBe
RCSB PDB
Protein
Vascular endothelial growth factor D
Species
Homo sapiens
O43915
92-194
UniProt
Representative domain 8070299
2XV7
A:92-194
PDBe
RCSB PDB
Protein
Beta-nerve growth factor
Species
Equus caballus
F6SVV7
184-290
UniProt
Representative domain 8097784
6XUO
A:10-116
PDBe
RCSB PDB
Protein
Sclerostin
Species
Mus musculus
Q99P68
71-167
UniProt
Representative domain 8106454
2KD3
A:48-144
PDBe
RCSB PDB