foldIsocitrate/Isopropylmalate dehydrogenase-like
superfamily
View {link.id} in {link.name}
Isocitrate/Isopropylmalate dehydrogenase-like
SCOP ID: 3001375
the constituent families form similar dimers
Families [ 5 entries ]
Dimeric isocitrate & isopropylmalate dehydrogenases
SCOP ID 4000791Structure Viewer
the active site is between the two identical subunits
PdxA-like
SCOP ID 4001202Structure Viewer
PF04166, contains extra beta-alpha unit between strands 2 and 3, closer relationships to the PlsX-like and phosphotransacetylase families
PlsX-like
SCOP ID 4001205Structure Viewer
PF02504, contains extra beta-alpha unit between strands 2 and 3, closer relationships to the PdxA-like and phosphotransacetylase families
Phosphotransacetylase-like
SCOP ID 4001208Structure Viewer
PF01515, contains extra beta-alpha unit between strands 2 and 3, closer relationships to the PdxA-like and PlsX-like families
Monomeric isocitrate dehydrogenase
SCOP ID 4003133Structure Viewer
the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion
Domains [ 74 entries ]
ID
Region
Links
ProteinIsocitrate dehydrogenase [NADP] cytoplasmic
SpeciesHomo sapiens
O75874
1-414
UniProt
Representative domain 8039863Structure Viewer
Represented structures [ 118 ]
1T0L
A:1-414
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesThermus thermophilus HB8
Q5SIY4
1-345
UniProt
Representative domain 8032767Structure Viewer
Represented structures [ 38 ]
1XAA
A:1-345
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesEscherichia coli K-12
P08200
1-416
UniProt
Representative domain 8034659Structure Viewer
Represented structures [ 36 ]
1PB1
A:1-416
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
SpeciesHomo sapiens
P50213
31-364
UniProt
Representative domain 8073659Structure Viewer
Represented structures [ 27 ]
5YVT
A:4-337
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP], mitochondrial
SpeciesSaccharomyces cerevisiae S288C
P21954
18-427
UniProt
Representative domain 8067350Structure Viewer
Represented structures [ 21 ]
2QFW
C:3-412
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NAD] subunit 2, mitochondrial
SpeciesSaccharomyces cerevisiae S288C
P28241
38-369
UniProt
Representative domain 8073661Structure Viewer
Represented structures [ 19 ]
3BLX
P:23-354
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase 2, chloroplastic
SpeciesArabidopsis thaliana
P93832
44-398
UniProt
Representative domain 8073665Structure Viewer
Represented structures [ 19 ]
5J33
H:44-398
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NAD] subunit 1, mitochondrial
SpeciesSaccharomyces cerevisiae S288C
P28834
24-360
UniProt
Representative domain 8076917Structure Viewer
Represented structures [ 19 ]
3BLX
A:13-349
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NAD] subunit beta, mitochondrial
SpeciesHomo sapiens
O43837
47-374
UniProt
Representative domain 8098166Structure Viewer
Represented structures [ 18 ]
6KDY
D:13-340
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase (NAD(+)), mitochondrial
SpeciesOstreococcus tauri
A0A096P8D3
65-469
UniProt
Representative domain 8096116Structure Viewer
Represented structures [ 15 ]
6IXT
B:24-428
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP], mitochondrial
SpeciesHomo sapiens
P48735
41-452
UniProt
Representative domain 8067344Structure Viewer
Represented structures [ 12 ]
4JA8
A:41-452
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesTrypanosoma brucei brucei TREU927
Q387G0
1-413
UniProt
Representative domain 8094068Structure Viewer
Represented structures [ 12 ]
6AJ6
A:1-413
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesBacillus coagulans
P12010
1-356
UniProt
Representative domain 8032793Structure Viewer
Represented structures [ 11 ]
2AYQ
A:1-356
PDBe
RCSB PDB
ProteinPhosphate acetyltransferase
SpeciesBacillus subtilis subsp. subtilis str. 168
P39646
1-323
UniProt
Representative domain 8043815Structure Viewer
Represented structures [ 11 ]
1XCO
A:1-323
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesShewanella oneidensis MR-1
Q8E9N3
2-364
UniProt
Representative domain 8076907Structure Viewer
Represented structures [ 11 ]
3VKZ
A:2-364
PDBe
RCSB PDB
ProteinIsocitrate/homoisocitrate dehydrogenase
SpeciesThermus thermophilus HB27
Q72IW9
2-334
UniProt
Representative domain 8099910Structure Viewer
Represented structures [ 9 ]
4YB4
C:2-334
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesCampylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Q9PLW0
3-357
UniProt
Representative domain 8073671Structure Viewer
Represented structures [ 8 ]
3UDU
B:3-357
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
SpeciesHomo sapiens
P51553
53-387
UniProt
Representative domain 8076919Structure Viewer
Represented structures [ 8 ]
5GRH
B:14-348
PDBe
RCSB PDB
ProteinPhosphate acetyltransferase
SpeciesMethanosarcina thermophila
P38503
2-333
UniProt
Representative domain 8036963Structure Viewer
Represented structures [ 7 ]
2AF4
C:2-333
PDBe
RCSB PDB
Protein4-hydroxythreonine-4-phosphate dehydrogenase
SpeciesEscherichia coli K-12
P19624
1-329
UniProt
Representative domain 8039069Structure Viewer
Represented structures [ 7 ]
1PTM
A:1-329
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesAzotobacter vinelandii
P16100
2-741
UniProt
Representative domain 8042476Structure Viewer
Represented structures [ 7 ]
1ITW
A:2-741
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesMycobacterium tuberculosis H37Rv
P9WKK9
2-336
UniProt
Representative domain 8043202Structure Viewer
Represented structures [ 7 ]
1W0D
A:2-336
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase (NADP(+))
SpeciesAeropyrum pernix K1
Q9YE81
3-423
UniProt
Representative domain 8073657Structure Viewer
Represented structures [ 7 ]
1XKD
B:6-426
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesTrypanosoma cruzi strain CL Brener
Q4E4L7
1-413
UniProt
Representative domain 8094038Structure Viewer
Represented structures [ 7 ]
6AJC
F:1-413
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesDesulfotalea psychrophila LSv54
Q6AQ66
1-401
UniProt
Representative domain 8067356Structure Viewer
Represented structures [ 6 ]
2UXQ
B:1-401
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase (NADP(+))
SpeciesSulfurisphaera tokodaii str. 7
Q96YK6
1-409
UniProt
Representative domain 8073655Structure Viewer
Represented structures [ 5 ]
2DHT
A:1-409
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesMycolicibacterium smegmatis MC2 155
A0QSZ3
6-740
UniProt
Representative domain 8077775Structure Viewer
Represented structures [ 5 ]
4ZDA
A:6-740
PDBe
RCSB PDB
ProteinTartrate dehydrogenase/decarboxylase
SpeciesPseudomonas putida
Q51945
5-364
UniProt
Representative domain 8076915Structure Viewer
Represented structures [ 4 ]
3FLK
A:5-364
PDBe
RCSB PDB
ProteinPhosphate acyltransferase
SpeciesBacillus subtilis subsp. subtilis str. 168
P71018
2-333
UniProt
Representative domain 8035852Structure Viewer
Represented structures [ 3 ]
1VI1
A:2-333
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP] cytoplasmic
SpeciesMus musculus
O88844
3-414
UniProt
Representative domain 8067340Structure Viewer
Represented structures [ 3 ]
5YZH
A:3-414
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP], mitochondrial
SpeciesMus musculus
P54071
40-452
UniProt
Representative domain 8067342Structure Viewer
Represented structures [ 3 ]
5H3F
A:40-452
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesPseudomonas aeruginosa UCBPP-PA14
Q02NB5
1-418
UniProt
Representative domain 8073645Structure Viewer
Represented structures [ 3 ]
5M2E
A:1-418
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesAcidithiobacillus thiooxidans
Q8GAX0
3-429
UniProt
Representative domain 8073651Structure Viewer
Represented structures [ 3 ]
2D4V
A:3-429
PDBe
RCSB PDB
ProteinHomoisocitrate dehydrogenase
SpeciesSchizosaccharomyces pombe 972h-
O14104
4-360
UniProt
Representative domain 8073663Structure Viewer
Represented structures [ 3 ]
3TY4
B:4-360
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesBurkholderia thailandensis E264
Q2T7H6
1-355
UniProt
Representative domain 8073667Structure Viewer
Represented structures [ 3 ]
4IWH
A:1-355
PDBe
RCSB PDB
ProteinHomoisocitrate dehydrogenase
SpeciesThermococcus kodakarensis KOD1
Q5JFV8
1-327
UniProt
Representative domain 8076911Structure Viewer
Represented structures [ 3 ]
5HN5
A:1-327
PDBe
RCSB PDB
ProteinIsocitrate/homoisocitrate dehydrogenase
SpeciesThermus thermophilus HB8
Q5SIJ1
2-334
UniProt
Representative domain 8076913Structure Viewer
Represented structures [ 3 ]
3ASJ
A:2-334
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesMycobacterium tuberculosis H37Rv
O53611
5-742
UniProt
Representative domain 8077773Structure Viewer
Represented structures [ 3 ]
5KVU
D:5-742
PDBe
RCSB PDB
ProteinPhosphate acetyltransferase
SpeciesPorphyromonas gingivalis ATCC 33277
B2RK03
2-336
UniProt
Representative domain 8097258Structure Viewer
Represented structures [ 3 ]
6IOW
B:2-336
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesShewanella benthica
D2YZL2
2-363
UniProt
Representative domain 8073669Structure Viewer
Represented structures [ 2 ]
3VMK
A:2-363
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesCorynebacterium glutamicum ATCC 13032
P50216
2-736
UniProt
Representative domain 8077777Structure Viewer
Represented structures [ 2 ]
2B0T
A:2-736
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase
SpeciesXanthomonas campestris pv. campestris str. 8004
A0A0H2XBX7
2-335
UniProt
Representative domain 8102313Structure Viewer
Represented structures [ 2 ]
6LTF
A:2-335
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesAcidithiobacillus ferrooxidans
Q56268
1-357
UniProt
Representative domain 8032794Structure Viewer
Represented structures [ 1 ]
1A05
A:1-357
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesSalmonella enterica subsp. enterica serovar Typhimurium str. LT2
P37412
1-363
UniProt
Representative domain 8032798Structure Viewer
Represented structures [ 1 ]
1CNZ
A:1-363
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesEscherichia coli K-12
P30125
1-363
UniProt
Representative domain 8032801Structure Viewer
Represented structures [ 1 ]
1CM7
A:1-363
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesBacillus subtilis subsp. subtilis str. 168
P39126
1-423
UniProt
Representative domain 8033245Structure Viewer
Represented structures [ 1 ]
1HQS
A:1-423
PDBe
RCSB PDB
ProteinPhosphate acetyltransferase
SpeciesStreptococcus pyogenes serotype M1
Q99ZQ5
1-329
UniProt
Representative domain 8040360Structure Viewer
Represented structures [ 1 ]
1R5J
A:1-329
PDBe
RCSB PDB
Protein4-hydroxythreonine-4-phosphate dehydrogenase
SpeciesSalmonella enterica subsp. enterica serovar Typhimurium str. LT2
P58717
3-329
UniProt
Representative domain 8040444Structure Viewer
Represented structures [ 1 ]
1R8K
A:3-329
PDBe
RCSB PDB
ProteinPhosphate acyltransferase
SpeciesEnterococcus faecalis V583
Q82ZE8
1-328
UniProt
Representative domain 8040748Structure Viewer
Represented structures [ 1 ]
1U7N
B:1-328
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP], mitochondrial (Fragment)
SpeciesSus scrofa
P33198
9-421
UniProt
Representative domain 8043127Structure Viewer
Represented structures [ 1 ]
1LWD
A:1-413
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesSulfurisphaera tokodaii str. 7
P50455
2-337
UniProt
Representative domain 8043679Structure Viewer
Represented structures [ 1 ]
1WPW
A:1-336
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesSinorhizobium meliloti 1021
Q92PG6
3-403
UniProt
Representative domain 8067346Structure Viewer
Represented structures [ 1 ]
3US8
B:3-403
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesMycobacterium tuberculosis H37Rv
P9WKL1
5-406
UniProt
Representative domain 8067348Structure Viewer
Represented structures [ 1 ]
4HCX
A:5-406
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesThermotoga maritima MSB8
Q9X0N2
1-399
UniProt
Representative domain 8067354Structure Viewer
Represented structures [ 1 ]
1ZOR
A:1-399
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Q5ZXB6
4-422
UniProt
Representative domain 8073647Structure Viewer
Represented structures [ 1 ]
6C0E
A:4-422
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesArchaeoglobus fulgidus DSM 4304
O29610
1-412
UniProt
Representative domain 8073653Structure Viewer
Represented structures [ 1 ]
2IV0
A:1-412
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesPseudomonas aeruginosa PAO1
Q9I0L4
5-741
UniProt
Representative domain 8077771Structure Viewer
Represented structures [ 1 ]
6G3U
A:5-741
PDBe
RCSB PDB
Protein4-hydroxythreonine-4-phosphate dehydrogenase
SpeciesPseudomonas aeruginosa PAO1
Q9I5U4
1-328
UniProt
Representative domain 8078252Structure Viewer
Represented structures [ 1 ]
1YXO
A:1001-1328
PDBe
RCSB PDB
ProteinD-threonate 4-phosphate dehydrogenase
SpeciesSalmonella enterica subsp. enterica serovar Typhimurium str. LT2
P58718
2-327
UniProt
Representative domain 8078254Structure Viewer
Represented structures [ 1 ]
2HI1
A:2-327
PDBe
RCSB PDB
Protein4-hydroxythreonine-4-phosphate dehydrogenase PdxA
SpeciesKlebsiella pneumoniae subsp. pneumoniae
A0A1Y0PY16
2-327
UniProt
Representative domain 8078256Structure Viewer
Represented structures [ 1 ]
6E85
B:2-327
PDBe
RCSB PDB
Protein4-hydroxythreonine-4-phosphate dehydrogenase
SpeciesParaburkholderia phymatum STM815
B2JVC5
13-342
UniProt
Representative domain 8078258Structure Viewer
Represented structures [ 1 ]
4JQP
A:13-342
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesSulfolobus acidocaldarius DSM 639
Q4JB37
2-337
UniProt
Representative domain 8079803Structure Viewer
Represented structures [ 1 ]
4Y1P
A:2-337
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesHaemophilus influenzae Rd KW20
P43860
1-358
UniProt
Representative domain 8094709Structure Viewer
Represented structures [ 1 ]
6XXY
A:1-358
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesAcinetobacter baumannii
V5VCI0
6-744
UniProt
Representative domain 8100884Structure Viewer
Represented structures [ 1 ]
5Z16
B:6-744
PDBe
RCSB PDB
ProteinPutative isocitrate dehydrogenase, NAD-dependent
SpeciesMethylococcus capsulatus str. Bath
Q602J2
1-339
UniProt
Representative domain 8102184Structure Viewer
Represented structures [ 1 ]
6LKY
A:1-339
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase (Fragment)
SpeciesPhaeodactylum tricornutum CCAP 1055/1
B7G620
5-357
UniProt
Representative domain 8103308Structure Viewer
Represented structures [ 1 ]
6LKZ
C:5-357
PDBe
RCSB PDB
Protein3-isopropylmalate dehydrogenase
SpeciesThermotoga maritima MSB8
Q9WZ26
1-354
UniProt
Representative domain 8041447Structure Viewer
1VLC
A:1-354
PDBe
RCSB PDB
ProteinPhosphate acetyltransferase EutD
SpeciesEscherichia coli K-12
P77218
2-323
UniProt
Representative domain 8043088Structure Viewer
1VMI
A:2-323
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesHungateiclostridium thermocellum ATCC 27405
A3DC45
2-402
UniProt
Representative domain 8067352Structure Viewer
4AOU
A:2-402
PDBe
RCSB PDB
ProteinIsocitrate dehydrogenase [NADP]
SpeciesBurkholderia pseudomallei 1710b
Q3JV82
3-419
UniProt
Representative domain 8073649Structure Viewer
3DMS
A:3-419
PDBe
RCSB PDB
Protein4-hydroxythreonine-4-phosphate dehydrogenase
SpeciesYersinia pestis
P58719
1-329
UniProt
Representative domain 8078250Structure Viewer
3LXY
A:1-329
PDBe
RCSB PDB
ProteinPhosphate acetyltransferase
SpeciesStaphylococcus aureus subsp. aureus MRSA252
Q6GJ80
1-327
UniProt
Representative domain 8080674Structure Viewer
4E4R
A:1-327
PDBe
RCSB PDB
Protein4-hydroxythreonine-4-phosphate dehydrogenase
SpeciesLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Q3V872
1-322
UniProt
Representative domain 8099424Structure Viewer
6XMY
A:1-322
PDBe
RCSB PDB
ProteinPhosphate acetyltransferase
SpeciesEscherichia coli
A0A0H0GLE6
387-713
UniProt
Representative domain 8106012Structure Viewer
7T88
A:387-713
PDBe
RCSB PDB