superfamily
View {link.id} in {link.name}
Thiamin diphosphate-binding fold (THDP-binding)
SCOP ID: 3001790
there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
Families [ 10 entries ]
the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
SCOP ID 4003561Structure Viewer
different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
parent family to TK and PFOR heterodimeric protein related to TK, alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
SCOP ID 4003577Structure Viewer
domains VI, I and II are arranged in the same way as the TK PP, Pyr and C domains
the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology
SCOP ID 4003587Structure Viewer
different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
parent family to TK and PFOR heterodimeric protein related to TK, alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
SCOP ID 4003596Structure Viewer
domains VI, I and II are arranged in the same way as the TK PP, Pyr and C domains
PF09364 CL0254
SCOP ID 4004301Structure Viewer
PF03894 CL0254
Domains [ 59 entries ]
ID
Region
Protein2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
SpeciesEscherichia coli K-12
1-173
Representative domain 8092255Structure Viewer
Represented structures [ 105 ]
A:1-173
Protein2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
SpeciesEscherichia coli K-12
367-538
Representative domain 8092257Structure Viewer
Represented structures [ 105 ]
A:367-538
ProteinBenzoylformate decarboxylase
SpeciesPseudomonas putida
2-181
Representative domain 8042169Structure Viewer
Represented structures [ 85 ]
A:2-181
ProteinBenzoylformate decarboxylase
SpeciesPseudomonas putida
342-524
Representative domain 8042170Structure Viewer
Represented structures [ 85 ]
A:342-524
ProteinMultifunctional 2-oxoglutarate metabolism enzyme
SpeciesMycolicibacterium smegmatis MC2 155
474-768
Representative domain 8093319Structure Viewer
Represented structures [ 61 ]
A:474-768
ProteinMultifunctional 2-oxoglutarate metabolism enzyme
SpeciesMycolicibacterium smegmatis MC2 155
835-1090
Representative domain 8093320Structure Viewer
Represented structures [ 61 ]
A:835-1090
ProteinPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
SpeciesHomo sapiens
30-390
Representative domain 8033333Structure Viewer
Represented structures [ 38 ]
A:1-361
ProteinPyruvate dehydrogenase E1 component subunit beta, mitochondrial
SpeciesHomo sapiens
32-221
Representative domain 8043740Structure Viewer
Represented structures [ 38 ]
B:2-191
ProteinAcetolactate synthase catalytic subunit, mitochondrial
SpeciesSaccharomyces cerevisiae S288C
89-263
Representative domain 8042434Structure Viewer
Represented structures [ 37 ]
A:89-263
ProteinAcetolactate synthase catalytic subunit, mitochondrial
SpeciesSaccharomyces cerevisiae S288C
461-687
Representative domain 8042435Structure Viewer
Represented structures [ 37 ]
A:461-687
ProteinAcetolactate synthase, chloroplastic
SpeciesArabidopsis thaliana
86-280
Representative domain 8034308Structure Viewer
Represented structures [ 34 ]
A:86-280
ProteinAcetolactate synthase, chloroplastic
SpeciesArabidopsis thaliana
460-667
Representative domain 8034310Structure Viewer
Represented structures [ 34 ]
A:460-667
ProteinPyruvate decarboxylase
SpeciesZymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
2-187
Representative domain 8044268Structure Viewer
Represented structures [ 33 ]
A:2-187
ProteinPyruvate decarboxylase
SpeciesZymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
363-566
Representative domain 8044269Structure Viewer
Represented structures [ 33 ]
A:363-566
ProteinN(2)-(2-carboxyethyl)arginine synthase
SpeciesStreptomyces clavuligerus
12-197
Representative domain 8034529Structure Viewer
Represented structures [ 25 ]
A:12-197
ProteinN(2)-(2-carboxyethyl)arginine synthase
SpeciesStreptomyces clavuligerus
375-572
Representative domain 8034530Structure Viewer
Represented structures [ 25 ]
A:375-572
Protein2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
SpeciesHomo sapiens
51-445
Representative domain 8032827Structure Viewer
Represented structures [ 24 ]
A:6-400
Protein2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
SpeciesHomo sapiens
52-254
Representative domain 8037947Structure Viewer
Represented structures [ 24 ]
B:2-204
ProteinXylulose-5-phosphate/fructose-6-phosphate phosphoketolase
SpeciesBifidobacterium longum
17-300
Representative domain 8052435Structure Viewer
Represented structures [ 23 ]
G:17-300
ProteinXylulose-5-phosphate/fructose-6-phosphate phosphoketolase
SpeciesBifidobacterium longum
409-607
Representative domain 8052436Structure Viewer
Represented structures [ 23 ]
G:409-607
ProteinPyruvate:ferredoxin oxidoreductase
SpeciesDesulfocurvibacter africanus
2-258
Representative domain 8039273Structure Viewer
Represented structures [ 21 ]
A:2-258
ProteinPyruvate:ferredoxin oxidoreductase
SpeciesDesulfocurvibacter africanus
786-1232
Representative domain 8039276Structure Viewer
Represented structures [ 21 ]
A:786-1232
ProteinPyruvate oxidase
SpeciesLactobacillus plantarum WCFS1
9-182
Representative domain 8040356Structure Viewer
Represented structures [ 19 ]
A:9-182
ProteinPyruvate oxidase
SpeciesLactobacillus plantarum WCFS1
366-593
Representative domain 8040359Structure Viewer
Represented structures [ 19 ]
A:366-593
ProteinPyruvate dehydrogenase E1 component subunit beta
SpeciesGeobacillus stearothermophilus
2-193
Representative domain 8043324Structure Viewer
Represented structures [ 19 ]
B:1-192
ProteinPyruvate dehydrogenase E1 component subunit alpha
SpeciesGeobacillus stearothermophilus
5-369
Representative domain 8043326Structure Viewer
Represented structures [ 19 ]
C:4-368
ProteinPyruvate decarboxylase isozyme 1
SpeciesSaccharomyces cerevisiae S288C
2-181
Representative domain 8044266Structure Viewer
Represented structures [ 17 ]
A:2-181
ProteinPyruvate decarboxylase isozyme 1
SpeciesSaccharomyces cerevisiae S288C
361-556
Representative domain 8044267Structure Viewer
Represented structures [ 17 ]
A:361-556
ProteinTransketolase 1
SpeciesEscherichia coli K-12
333-527
Representative domain 8036680Structure Viewer
Represented structures [ 15 ]
A:333-527
ProteinTransketolase 1
SpeciesEscherichia coli K-12
2-332
Representative domain 8036682Structure Viewer
Represented structures [ 15 ]
A:2-332
ProteinPyruvate dehydrogenase E1 component
SpeciesEscherichia coli K-12
472-701
Representative domain 8041598Structure Viewer
Represented structures [ 15 ]
A:471-700
ProteinPyruvate dehydrogenase E1 component
SpeciesEscherichia coli K-12
57-471
Representative domain 8041600Structure Viewer
Represented structures [ 15 ]
A:56-470
ProteinTransketolase 1
SpeciesSaccharomyces cerevisiae S288C
3-337
Representative domain 8036144Structure Viewer
Represented structures [ 13 ]
A:3-337
ProteinTransketolase 1
SpeciesSaccharomyces cerevisiae S288C
338-534
Representative domain 8036146Structure Viewer
Represented structures [ 13 ]
A:338-534
ProteinAcetolactate synthase, catabolic
SpeciesKlebsiella pneumoniae
6-187
Representative domain 8037999Structure Viewer
Represented structures [ 13 ]
A:6-187
ProteinAcetolactate synthase, catabolic
SpeciesKlebsiella pneumoniae
367-554
Representative domain 8038001Structure Viewer
Represented structures [ 13 ]
A:367-554
ProteinOxalyl-CoA decarboxylase
SpeciesOxalobacter formigenes
7-194
Representative domain 8034662Structure Viewer
Represented structures [ 11 ]
A:7-194
ProteinOxalyl-CoA decarboxylase
SpeciesOxalobacter formigenes
370-552
Representative domain 8034663Structure Viewer
Represented structures [ 11 ]
A:370-552
Protein2-oxoisovalerate dehydrogenase subunit beta
SpeciesThermus thermophilus HB8
2-187
Representative domain 8041900Structure Viewer
Represented structures [ 7 ]
B:2-187
Protein2-oxoisovalerate dehydrogenase subunit alpha
SpeciesThermus thermophilus HB8
6-367
Representative domain 8041906Structure Viewer
Represented structures [ 7 ]
A:6-367
ProteinProbable phosphoketolase
SpeciesBifidobacterium breve
17-300
Representative domain 8052432Structure Viewer
Represented structures [ 7 ]
A:17-300
ProteinProbable phosphoketolase
SpeciesBifidobacterium breve
409-606
Representative domain 8052433Structure Viewer
Represented structures [ 7 ]
A:409-606
Protein2-oxoisovalerate dehydrogenase subunit beta
SpeciesPseudomonas putida
2-205
Representative domain 8044275Structure Viewer
Represented structures [ 4 ]
B:2-205
Protein2-oxoisovalerate dehydrogenase subunit alpha
SpeciesPseudomonas putida
2-408
Representative domain 8044276Structure Viewer
Represented structures [ 4 ]
A:2-408
ProteinIndole-3-pyruvate decarboxylase
SpeciesEnterobacter cloacae
3-180
Representative domain 8034390Structure Viewer
Represented structures [ 3 ]
A:3-180
ProteinIndole-3-pyruvate decarboxylase
SpeciesEnterobacter cloacae
356-551
Representative domain 8034394Structure Viewer
Represented structures [ 3 ]
A:356-551
Protein2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
SpeciesBacillus subtilis subsp. subtilis str. 168
2-176
Representative domain 8092250Structure Viewer
Represented structures [ 3 ]
C:2-176
Protein2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
SpeciesBacillus subtilis subsp. subtilis str. 168
381-555
Representative domain 8092252Structure Viewer
Represented structures [ 3 ]
C:381-555
Protein2-oxoglutarate dehydrogenase E1 component
SpeciesEscherichia coli K-12
195-407
Representative domain 8093314Structure Viewer
Represented structures [ 3 ]
A:195-407
Protein2-oxoglutarate dehydrogenase E1 component
SpeciesEscherichia coli K-12
549-799
Representative domain 8093315Structure Viewer
Represented structures [ 3 ]
A:549-799
ProteinTransketolase, chloroplastic
SpeciesZea mays
10-347
Representative domain 8042478Structure Viewer
Represented structures [ 2 ]
A:10-347
ProteinTransketolase, chloroplastic
SpeciesZea mays
348-539
Representative domain 8042480Structure Viewer
Represented structures [ 2 ]
A:348-539
ProteinPyruvate oxidase (Fragment)
SpeciesAerococcus viridans
3-186
Representative domain 8039799Structure Viewer
Represented structures [ 1 ]
A:3-186
ProteinPyruvate oxidase (Fragment)
SpeciesAerococcus viridans
364-592
Representative domain 8039801Structure Viewer
Represented structures [ 1 ]
A:364-592
ProteinTransketolase
SpeciesLeishmania mexicana mexicana
337-526
Representative domain 8042199Structure Viewer
Represented structures [ 1 ]
A:337-526
ProteinTransketolase
SpeciesLeishmania mexicana mexicana
1-336
Representative domain 8042200Structure Viewer
Represented structures [ 1 ]
A:1-336
Protein2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
SpeciesListeria monocytogenes serotype 4b str. F2365
2-178
Representative domain 8092260Structure Viewer
Represented structures [ 1 ]
A:2-178
Protein2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
SpeciesListeria monocytogenes serotype 4b str. F2365
385-555
Representative domain 8092262Structure Viewer
Represented structures [ 1 ]
A:385-555
ProteinPyruvate dehydrogenase
SpeciesPyrobaculum aerophilum
-
1-191