Entry status  (1)

REL

(58)

Experimental methods  (3)

X-ray diffraction

(40)

Solution NMR

(10)

Electron Microscopy

(8)

Authors  (363)

Suzuki T

(9)

Ortega E

(7)

Panne D

(7)

Poy F

(7)

Bommi-Reddy A

(6)

Brucelle F

(6)

Cole PA

(6)

Cummings R

(6)

Gardberg AS

(6)

Huhn AJ

(6)

Khochbin S

(6)

Marmorstein R

(6)

Vivat V

(6)

Dohmae N

(5)

Kikuchi M

(5)

Morita S

(5)

Sato S

(5)

Shin S

(5)

Shirouzu M

(5)

Uchikubo-Kamo T

(5)

Umehara T

(5)

Wakamori M

(5)

Asano M

(4)

Audia JE

(4)

Cantone N

(4)

Goudarzi A

(4)

Hanzawa H

(4)

Higuchi S

(4)

Huang H

(4)

Isoyama T

(4)

Kaczmarska Z

(4)

Kagoshima Y

(4)

Kanada R

(4)

Kihara K

(4)

Kim S

(4)

Kuroha M

(4)

Levell J

(4)

Li W

(4)

Marquez JA

(4)

Márquez JA

(4)

Naito H

(4)

Patel C

(4)

Patel G

(4)

Sato K

(4)

Sims R

(4)

Suzuki K

(4)

Takahashi M

(4)

Tominaga Y

(4)

Tropea JE

(4)

Ubukata O

(4)

Wilson JE

(4)

Zhao Y

(4)

Bai X

(3)

Banjo T

(3)

Barton L

(3)

Berrodin TJ

(3)

Boehm J

(3)

Breit B

(3)

Cecconie T

(3)

Cherry S

(3)

Di Marco C

(3)

Einsle O

(3)

Gao E

(3)

Gaucher J

(3)

Gerhardt S

(3)

Graves AP

(3)

Gunther S

(3)

Günther S

(3)

Haruta M

(3)

Hashimoto K

(3)

Hau M

(3)

Heerding D

(3)

Huegle M

(3)

Hugle M

(3)

Hügle M

(3)

Jung M

(3)

King EA

(3)

Knight S

(3)

LaFrance L

(3)

Lind K

(3)

Lucas X

(3)

Maksimoska J

(3)

Mangatt B

(3)

Martyr C

(3)

McHugh C

(3)

Medina J

(3)

Messer J

(3)

Miller M

(3)

Murata T

(3)

Nartey E

(3)

Nixon C

(3)

Obata K

(3)

Ostrovskyi D

(3)

Patel A

(3)

Phelps C

(3)

Prabhu N

(3)

Regenass P

(3)

Reid R

(3)

Reid RA

(3)

Segura-Pena D

(3)

 

More...

Homo / hetero assembly  (2)

homo

(41)

hetero

(16)

Assembly composition  (3)

protein structure

(41)

protein/protein complex

(9)

DNA/protein complex

(7)

Assembly polymer count  (5)

monomer

(38)

dimer

(11)

undecamer

(6)

tridecamer

(1)

trimer

(1)

Resolution distribution

1.0 - 1.5

(3)

1.5 - 2

(11)

2.0 - 2.5

(17)

2.5 - 3

(6)

3.0 - 3.5

(4)

3.5 - 4

(2)

4.0 - 4.5

(1)

4.5 - 5

(2)

9.5 - 10

(1)

10.5 - 11

(1)

Release year distribution

2000 - 2005

(2)

2005 - 2010

(4)

2010 - 2015

(9)

2015 - 2020

(23)

2020 - 2025

(26)

2025 - 2030

(1)

Journal  (23)

Nat Commun

(8)

Biochemistry

(6)

Bioorg Med Chem Lett

(4)

ChemMedChem

(4)

J Med Chem

(4)

Nat Chem Biol

(4)

Nature

(4)

Angew Chem Int Ed Engl

(3)

Structure

(3)

Acta Crystallogr D Biol Crystallogr

(2)

Nat Struct Mol Biol

(2)

Struct Dyn

(2)

To be published

(2)

Acta Pharmacol Sin

(1)

Biochem Biophys Res Commun

(1)

Biochim Biophys Acta Mol Cell Res

(1)

Cell

(1)

J Biol Chem

(1)

Nat Struct Biol

(1)

Nucleic Acids Res

(1)

Proc Natl Acad Sci U S A

(1)

RSC Chem Biol

(1)

iScience

(1)

Organism superkingdom  (2)

Eukaryota

(58)

Bacteria

(1)

Organism name  (2)

Homo sapiens

(58)

Thermus scotoductus

(1)

Molecule name  (26)

E1A-associated protein p300

(58)

Histone acetyltransferase p300

(58)

Histone butyryltransferase p300

(58)

Histone crotonyltransferase p300

(58)

Protein 2-hydroxyisobutyryltransferase p300

(58)

Protein lactyltransferas p300

(58)

Protein propionyltransferase p300

(58)

p300 HAT

(58)

C/EBP epsilon

(1)

CCAAT/enhancer-binding protein epsilon

(1)

CUSP

(1)

Chronic ulcerative stomatitis protein

(1)

Keratinocyte transcription factor KET

(1)

NUT family member 1

(1)

Nuclear protein in testis

(1)

TP63

(1)

Transformation-related protein 63

(1)

Tumor protein 63

(1)

Tumor protein p73

(1)

Tumor protein p73-like

(1)

p40

(1)

p51

(1)

p53-like transcription factor

(1)

p53-related protein

(1)

p63

(1)

p73L

(1)

Molecule type  (1)

Protein

(58)

Gene names  (14)

EP300

(58)

P300

(58)

C15orf55

(1)

CEBPE

(1)

KET

(1)

NUT

(1)

NUTM1

(1)

P63

(1)

P73

(1)

P73H

(1)

P73L

(1)

TP63

(1)

TP73

(1)

TP73L

(1)

Interacting Molecules  (16)

Histone H4

(7)

Histone H2A type 1-B/E

(6)

Histone H2B type 1-J

(6)

Histone H3.1

(6)

DNA (180-mer)

(5)

Cbp/p300-interacting transactivator 2

(2)

Cellular tumor antigen p53

(2)

Hypoxia-inducible factor 1-alpha

(2)

DNA (145-MER)

(1)

DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3')

(1)

DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3')

(1)

Histone acetyltransferase p300

(1)

Microphthalmia-associated transcription factor

(1)

Myocyte-specific enhancer factor 2A

(1)

NUT family member 1

(1)

Transcription factor E2-alpha

(1)

Interacting ligands  (44)

ZN : ZINC ION

(25)

CL : CHLORIDE ION

(6)

DMS : DIMETHYL SULFOXIDE

(6)

EDO : 1,2-ETHANEDIOL

(6)

SO4 : SULFATE ION

(6)

COA : COENZYME A

(5)

01K : [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate

(3)

GOL : GLYCEROL

(3)

ACT : ACETATE ION

(2)

PEG : DI(HYDROXYETHYL)ETHER

(2)

1VU : propionyl Coenzyme A

(1)

2LO : 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole

(1)

6QI : [(6R)-6-(1H-indazol-4-ylmethyl)-1,4-oxazepan-4-yl]-[1-(4-methoxyphenyl)cyclopentyl]methanone

(1)

6TF : N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide

(1)

6TI : (2R)-N-(2H-indazol-4-yl)-1-[1-(4-methoxyphenyl)cyclopentyl]carbonyl-pyrrolidine-2-carboxamide

(1)

6YI : (4S)-N-(3H-indazol-4-yl)-3-[1-(4-methoxyphenyl)cyclopentyl]carbonyl-1,1-bis(oxidanylidene)-1,3-thiazolidine-4-carboxamide

(1)

71Y : ~{N}-[(1~{S},2~{S})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole -2-carboxamide

(1)

99E : ~{N}-[[2,8-bis(oxidanyl)naphthalen-1-yl]methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide

(1)

A1EDM : (6~{S})-1-(3-chloranyl-4-methoxy-phenyl)-6-[4-(3-methyl-1,2-benzoxazol-5-yl)-1-[(2~{S})-2-morpholin-4-ylpropyl]imidazol-2-yl]piperidin-2-one

(1)

ACO : ACETYL COENZYME *A

(1)

BCO : Butyryl Coenzyme A

(1)

C0C : 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-{[3-(methylcarbamoyl)phenyl]methyl}-D-prolinamide

(1)

C3I : N-[2-(4-methoxyanilino)-2-oxoethyl]-N-methyl-1-phenylcyclopentane-1-carboxamide

(1)

COO : CROTONYL COENZYME A

(1)

ETL : 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-1H-pyrazolo[4,3-b]pyridin-5-yl-D-prolinamide

(1)

IPA : ISOPROPYL ALCOHOL

(1)

JHL : (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one

(1)

KQO : (2~{R},4~{R})-4-fluoranyl-1-[1-(4-methoxyphenyl)cyclohexyl]carbonyl-~{N}-(1~{H}-pyrazolo[4,3-b]pyridin-5-yl)pyrrolidine-2-carboxamide

(1)

N6I : (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one

(1)

NA : SODIUM ION

(1)

NI : NICKEL (II) ION

(1)

OJ7 : 3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methyl-1H-indole

(1)

OK7 : N-(thiophen-2-yl)acetamide

(1)

PE5 : 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL

(1)

PG4 : TETRAETHYLENE GLYCOL

(1)

QRY : 4-(2-{[(1R)-2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino}ethyl)benzene-1-sulfonamide

(1)

QS1 : (2R)-2-{[(2S)-2-(4-cyanophenyl)propyl]amino}-N-[5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl]-2-phenylacetamide

(1)

QS4 : 1-(2-methyl-1H-indol-3-yl)-2-[(2R)-2-methylpiperidin-1-yl]ethan-1-one

(1)

QSD : (2R)-2-{[2-(4-cyanophenyl)ethyl]amino}-N-[5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl]-2-phenylacetamide

(1)

SOP : [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-{[3-OXO-3-({2-[(2-OXOPROPYL)THIO]ETHYL}AMINO)PROPYL]AMINO}BUTYL DIHYDROGEN DIPHOSPHATE

(1)

TAM : TRIS(HYDROXYETHYL)AMINOMETHANE

(1)

TCE : 3,3',3''-phosphanetriyltripropanoic acid

(1)

XDM : ~{N}-[(3-chlorophenyl)methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide

(1)

Y2P : 2-[4-[(3'R,4S)-3'-fluoro-1-[2-[(4-fluorophenyl)methyl-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]-2-oxo-ethyl]-2,5-dioxo-spiro[imidazolidine-4,1'-indane]-5'-yl]pyrazol-1-yl]-N-methyl-acetamide

(1)

EC number / name  (1)

2.3.1.48 : Histone acetyltransferase

(58)

Biological function  (2)

histone acetyltransferase activity

(49)

zinc ion binding

(7)

Biological process  (1)

regulation of DNA-templated transcription

(49)

Compound cofactor class  (1)

Coenzyme A

(13)

SCOP fold  (1)

TAZ domain

(2)

SCOP family  (1)

TAZ domain

(2)

CATH class  (3)

Mainly Alpha

(18)

Alpha Beta

(6)

Mainly Beta

(5)

CATH topology  (5)

Histone Acetyltransferase; Chain A

(10)

CREB-binding Protein; Chain A

(8)

Cysteine Rich Protein

(5)

Herpes Virus-1

(5)

Wheat Germ Agglutinin (Isolectin 2); domain 1

(1)

Pfam accession / name  (6)

PF08214 : HAT_KAT11

(33)

PF00439 : Bromodomain

(25)

PF06001 : RING_CBP-p300

(21)

PF02135 : zf-TAZ

(19)

PF00569 : ZZ

(7)

PF02172 : KIX

(1)

Diffraction protocol  (2)

Single wavelength

(40)

MAD

(2)

Diffraction radiation source type  (2)

Synchrotron

(37)

Rotating anode

(3)

Diffraction source  (23)

APS BEAMLINE 22-ID

(4)

APS BEAMLINE 22-BM

(3)

ESRF BEAMLINE ID23-2

(3)

ESRF BEAMLINE ID29

(3)

NSLS BEAMLINE X6A

(3)

SLS BEAMLINE X06SA

(3)

APS BEAMLINE 17-ID

(2)

APS BEAMLINE 21-ID-D

(2)

PHOTON FACTORY BEAMLINE BL-1A

(2)

RIGAKU MICROMAX-007

(2)

ALBA BEAMLINE XALOC

(1)

ALS BEAMLINE 4.2.2

(1)

ALS BEAMLINE 8.2.1

(1)

CLSI BEAMLINE 08ID-1

(1)

DIAMOND BEAMLINE I02

(1)

DIAMOND BEAMLINE I04

(1)

ESRF BEAMLINE ID14-4

(1)

ESRF BEAMLINE ID30B

(1)

NSLS BEAMLINE X29A

(1)

PAL/PLS BEAMLINE 5C (4A)

(1)

RIGAKU MICROMAX-007 HF

(1)

SLS BEAMLINE X10SA

(1)

SSRF BEAMLINE BL02U1

(1)

Synchrotron site  (11)

APS

(11)

ESRF

(8)

NSLS

(4)

SLS

(4)

ALS

(2)

Diamond

(2)

Photon Factory

(2)

ALBA

(1)

CLSI

(1)

PAL/PLS

(1)

SSRF

(1)

Diffraction detector type  (4)

Pixel

(23)

CCD

(14)

Image plate

(2)

CMOS

(1)

Refinement software  (5)

PHENIX

(24)

REFMAC

(19)

phenix.real_space_refine

(5)

BUSTER

(2)

CNS

(1)

EM microscope model  (4)

FEI TECNAI ARCTICA

(3)

FEI POLARA 300

(2)

TFS KRIOS

(2)

FEI TITAN KRIOS

(1)

EM detector name  (3)

GATAN K2 SUMMIT (4k x 4k)

(3)

GATAN K3 BIOQUANTUM (6k x 4k)

(3)

FEI EAGLE (4k x 4k)

(2)

NMR software packages  (23)

NMRPipe

(6)

CNS

(5)

CYANA

(4)

NMRView

(4)

ARIA

(3)

CcpNmr Analysis

(2)

NMRDraw

(2)

OPAL

(2)

PROCHECK / PROCHECK-NMR

(2)

PROSA

(2)

Sparky

(2)

TALOS

(2)

TopSpin

(2)

VNMR

(2)

VnmrJ

(2)

X-PLOR

(2)

XEASY

(2)

DYANA

(1)

Insight II

(1)

MolProbity

(1)

SYBYL

(1)

Xplor-NIH

(1)

XwinNMR

(1)

NMR Field Strength

400.0 - 500

(5)

500.0 - 600

(10)

600.0 - 700

(8)

700.0 - 800

(9)

800.0 - 900

(5)

900.0 - 1000

(2)

Representative Structures

100%

95%

90%

70%

50%

40%

30%