Uniprot accession / id : B9EJ86  OR   Uniprot accession / id : Q9BZF1  OR   Uniprot accession / id : F8VVD3  OR   Uniprot accession / id : F8VUA7
 
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Entry Information
Entry status  (1)
REL
(4)
 
Experimental methods  (2)
X-ray diffraction
(3)
Solution NMR
(1)
 
Authors  (24)
Brown AJ
(2)
Dong J
(2)
Du X
(2)
Ferguson C
(2)
Ghai R
(2)
Parton RG
(2)
Wang H
(2)
Wu JW
(2)
Yang H
(2)
Anila MM
(1)
Boura E
(1)
Eisenreichova A
(1)
Humpolickova J
(1)
Inoue M
(1)
Kigawa T
(1)
Klima M
(1)
Koshiba S
(1)
Koukalova A
(1)
Li H
(1)
RIKEN Structural Genomics/Proteomics Initiative (RSGI)
(1)
Rozycki B
(1)
Różycki B
(1)
Tomizawa T
(1)
Yokoyama S
(1)
 
Homo / hetero assembly  (1)
homo
(4)
 
Assembly composition  (1)
protein structure
(4)
 
Assembly polymer count  (1)
monomer
(4)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(1)
2.5 - 3
(1)
 
Release year distribution
2000 - 2005
(1)
2015 - 2020
(2)
2020 - 2025
(1)
 
Journal  (3)
Nat Commun
(2)
Cells
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(4)
 
Organism name  (1)
Homo sapiens
(4)
 
Molecule name  (3)
ORP-8
(4)
OSBP-related protein 8
(4)
Oxysterol-binding protein-related protein 8
(4)
 
Molecule type  (1)
Protein
(4)
 
Gene names  (4)
KIAA1451
(4)
ORP8
(4)
OSBP10
(4)
OSBPL8
(4)
 
Interacting ligands  (2)
FMT : FORMIC ACID
(1)
NDB : N-(2-hydroxyethyl)-N,N-dimethyl-3-sulfopropan-1-aminium
(1)
 
Function and Biology
Biological function  (1)
lipid binding
(1)
 
Sequence and Structure classification
SCOP fold  (1)
PH domain-like barrel
(1)
 
SCOP family  (1)
Pleckstrin-homology domain (PH domain)
(1)
 
CATH class  (1)
Mainly Beta
(3)
 
CATH topology  (1)
PH-domain like
(3)
 
Pfam accession / name  (2)
PF00169 : PH
(3)
PF01237 : Oxysterol_BP
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(4)
 
Diffraction radiation source type  (1)
Synchrotron
(3)
 
Diffraction source  (2)
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
(2)
BESSY BEAMLINE 14.2
(1)
 
Synchrotron site  (2)
Australian Synchrotron
(2)
BESSY
(1)
 
Diffraction detector type  (2)
CCD
(2)
Pixel
(1)
 
Refinement software  (1)
PHENIX
(3)
 
NMR
NMR software packages  (5)
CYANA
(1)
KUJIRA
(1)
NMRPipe
(1)
NMRView
(1)
XwinNMR
(1)
 
NMR Field Strength
700.0 - 800
(1)
800.0 - 900
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 4 of 4
Entries 1 to 4 of 4
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Crystal structure of ORP8 PH domain in P1211 space group
Ghai R, Yang H
Nat Commun (2017) [PMID: 28970484  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Oxysterol-binding protein-related protein 8 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189858 (Preferred)   search this ID
PDBe-KB: Q9BZF1   
X-ray diffraction
1.978Å resolution
Released: 18 Oct 2017
Model geometry
Fit model/data
5u78
5u78
5u78
Crystal structure of ORP8 PH domain
Ghai R, Yang H
Nat Commun (2017) [PMID: 28970484  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: FMT    NDB    FMT    NDB   
Assembly name: Oxysterol-binding protein-related protein 8 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189858 (Preferred)   search this ID
PDBe-KB: Q9BZF1   
X-ray diffraction
2.157Å resolution
Released: 18 Oct 2017
Model geometry
Fit model/data
5u77
5u77
5u77
Crystal structure of the ORD domain of human ORP8
Eisenreichova A, Klima M, Boura E
Cells (2023) [PMID: 37566053  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Oxysterol-binding protein-related protein 8 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189858 (Preferred)   search this ID
PDBe-KB: Q9BZF1   
X-ray diffraction
2.56Å resolution
Released: 23 Aug 2023
Model geometry
Fit model/data
8p7a
8p7a
8p7a
Solution Structure of the Pleckstrin Homology Domain of Oxysterol-Binding Protein-Related Protein 8 (KIAA1451 Protein)
Li H, Tomizawa T, Koshiba S, Inoue M, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Oxysterol-binding protein-related protein 8 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189858 (Preferred)   search this ID
PDBe-KB: Q9BZF1   
Solution NMR
Released: 29 Jun 2004
Model geometry
Fit model/data
Data not deposited
1v88
1v88
1v88
Entries 1 to 4 of 4
Entries 1 to 4 of 4