Uniprot accession / id : D3YXF5  OR   Uniprot accession / id : P10643
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Entry Information
Entry status  (1)
REL
(8)
 
Experimental methods  (2)
Electron Microscopy
(7)
Solution NMR
(1)
 
Authors  (23)
Bubeck D
(7)
Couves EC
(5)
Gardner S
(5)
Menny A
(4)
Bickel JK
(3)
Stansfeld PJ
(3)
Tate EW
(3)
Voisin TB
(3)
Boyd CM
(2)
Brooks NJ
(2)
Franc V
(2)
Heck AJR
(2)
Joseph AP
(2)
Lukassen MV
(2)
Morgan BP
(2)
Serna M
(2)
Topf M
(2)
Barlow PN
(1)
Bramham J
(1)
Ogata RT
(1)
Phelan MM
(1)
Soares DC
(1)
Thai CT
(1)
 
Homo / hetero assembly  (2)
hetero
(7)
homo
(1)
 
Assembly composition  (2)
protein/protein complex
(7)
protein structure
(1)
 
Assembly polymer count  (6)
24-mer
(2)
nonamer
(2)
decamer
(1)
heptamer
(1)
monomer
(1)
octamer
(1)
 
Resolution distribution
2.5 - 3
(1)
3.0 - 3.5
(3)
3.5 - 4
(1)
5.5 - 6
(2)
 
Release year distribution
2005 - 2010
(1)
2015 - 2020
(2)
2020 - 2025
(5)
 
Journal  (2)
Nat Commun
(7)
J Biol Chem
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(8)
 
Organism name  (1)
Homo sapiens
(8)
 
Representative Structures
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Entries 1 to 8 of 8
Entries 1 to 8 of 8
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8b0h
2C9, C5b9-CD59 cryoEM structure
Couves EC, Gardner S, Bubeck D
Nat Commun (2023) [PMID: 36797260  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: C5b6 complement complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133865 (Preferred)   search this ID
PDBe-KB: P10643    P07360    P13987    P01031    P02748    P13671    (view 2 more)
Electron Microscopy
3.3Å resolution
Released: 22 Feb 2023
DOI: 10.2210/pdb8b0h  
Model geometry
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Data not analysed
8b0h
8b0h
8b0h
8b0f
CryoEM structure of C5b8-CD59
Bubeck D, Couves EC, Gardner S
Nat Commun (2023) [PMID: 36797260  ]
Source organisms: Escherichia coli  , Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CA    NAG    CA    NAG   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Molecule 2 - BMA(1), NAG(1)
Assembly name: C5b6 complement complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133868 (Preferred)   search this ID
PDBe-KB: P10643    P07360    P13987    P01031    P13671    P07358    (view 1 more)
Electron Microscopy
3Å resolution
Released: 22 Feb 2023
DOI: 10.2210/pdb8b0f  
Model geometry
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8b0f
8b0f
8b0f
8b0g
2C9, C5b9-CD59 structure
Couves EC, Gardner S, Bubeck D
Nat Commun (2023) [PMID: 36797260  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Assembly name: C5b6 complement complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133867 (Preferred)   search this ID
PDBe-KB: P10643    P07360    P13987    P01031    P02748    P13671    (view 2 more)
Electron Microscopy
3.3Å resolution
Released: 22 Feb 2023
DOI: 10.2210/pdb8b0g  
Model geometry
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Data not analysed
8b0g
8b0g
8b0g
7nyd
cryoEM structure of 2C9-sMAC
Menny A, Couves EC, Bubeck D
Nat Commun (2021) [PMID: 34667172  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CA    NAG    CA    FUC    MAN    NAG    FUC    MAN   
Carbohydrate polymer components:
Molecule 1 - BMA(1), NAG(2)
Molecule 2 - NAG(2)
Molecule 3 - BMA(1), MAN(2), NAG(2)
Assembly name: C5b6 complement complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133864 (Preferred)   search this ID
PDBe-KB: P10643    P07360    P01031    P02748    P13671    P07358    (view 1 more)
Electron Microscopy
3.27Å resolution
Released: 6 Oct 2021
DOI: 10.2210/pdb7nyd  
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7nyd
7nyd
7nyd
7nyc
cryoEM structure of 3C9-sMAC
Menny A, Couves EC, Bubeck D
Nat Commun (2021) [PMID: 34667172  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CA    NAG    CA    FUC    MAN    NAG    FUC    MAN   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Molecule 2 - BMA(1), NAG(2)
Assembly name: C5b6 complement complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133866 (Preferred)   search this ID
PDBe-KB: P10643    P07360    P01031    P02748    P13671    P07358    (view 1 more)
Electron Microscopy
3.54Å resolution
Released: 6 Oct 2021
DOI: 10.2210/pdb7nyc  
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7nyc
7nyc
7nyc
2wcy
NMR solution structure of factor I-like modules of complement C7.
Phelan MM, Thai CT, Soares DC, Ogata RT, Barlow PN, Bramham J
J Biol Chem (2009) [PMID: 19419965  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Complement component C7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145407 (Preferred)   search this ID
PDBe-KB: P10643   
Solution NMR
Released: 19 May 2009
DOI: 10.2210/pdb2wcy  
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2wcy
2wcy
2wcy
6h04
Closed conformation of the Membrane Attack Complex
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Topf M, Bubeck D
Nat Commun (2018) [PMID: 30552328  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Assembly name: C5b6 complement complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133863 (Preferred)   search this ID
PDBe-KB: P10643    P07360    P01031    P02748    P13671    P07358    (view 1 more)
Electron Microscopy
5.6Å resolution
Released: 19 Dec 2018
DOI: 10.2210/pdb6h04  
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6h04
6h04
6h04
6h03
OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Topf M, Bubeck D
Nat Commun (2018) [PMID: 30552328  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Carbohydrate polymer components:
Molecule 1 - BMA(1), NAG(2)
Molecule 2 - NAG(2)
Assembly name: C5b6 complement complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133863 (Preferred)   search this ID
PDBe-KB: P10643    P07360    P01031    P02748    P13671    P07358    (view 1 more)
Electron Microscopy
5.6Å resolution
Released: 19 Dec 2018
DOI: 10.2210/pdb6h03  
Model geometry
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Data not analysed
6h03
6h03
6h03
Entries 1 to 8 of 8
Entries 1 to 8 of 8