Uniprot accession / id : E9Q5F9  OR   Uniprot accession / id : Q9BYW2
 
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Entry Information
Entry status  (1)
REL
(34)
 
Experimental methods  (3)
X-ray diffraction
(25)
Electron Microscopy
(5)
Solution NMR
(4)
 
Authors  (167)
Acklam P
(7)
Amin N
(7)
Berdini V
(7)
Burke R
(7)
Chiarparin E
(7)
Coyle JE
(7)
Drouin L
(7)
Harmer JE
(7)
Heightman TD
(7)
Hoelder S
(7)
Hold A
(7)
Holding FP
(7)
Jeganathan F
(7)
Martin AC
(7)
Newbatt Y
(7)
Pathuri P
(7)
Rich SJ
(7)
Tamanini E
(7)
Tisi D
(7)
Tortorici M
(7)
Westlake M
(7)
Wood A
(7)
Yon J
(7)
van Montfort RL
(7)
Heightman T
(6)
Li H
(6)
Alford JS
(5)
Brach D
(5)
Cosmopoulos K
(5)
Duncan KW
(5)
Eckley ST
(5)
Farrow NA
(5)
Lampe JW
(5)
Raimondi A
(5)
Riera TV
(5)
Tang C
(5)
Totman J
(5)
Zhang Y
(5)
Allis CD
(4)
Farnung L
(4)
Li F
(4)
Markert JW
(4)
Soffers JH
(4)
Yang S
(4)
Arrowsmith CH
(3)
Boriack-Sjodin P
(3)
Boriak-Sjodin PA
(3)
Bountra C
(3)
Edwards AM
(3)
Foley MA
(3)
Gao YG
(3)
Harvey DM
(3)
Hu HY
(3)
Jiang YJ
(3)
Li GM
(3)
Lu C
(3)
Markert J
(3)
Min J
(3)
Motwani V
(3)
Munchhof MJ
(3)
Structural Genomics Consortium (SGC)
(3)
Thomenius MJ
(3)
Yang H
(3)
Zhao J
(3)
Zheng X
(3)
Allali-Hassani A
(2)
Amaya MF
(2)
Bao K
(2)
Bhattacharya S
(2)
Blum G
(2)
Brown PJ
(2)
Chesworth R
(2)
Dong A
(2)
Florens L
(2)
Hajian T
(2)
Haouz A
(2)
Ibanez G
(2)
Ibáñez G
(2)
Jia S
(2)
Kutok JL
(2)
Li FD
(2)
Luo M
(2)
Mechaly AE
(2)
Michail C
(2)
Reddy D
(2)
Schapira M
(2)
Shan CM
(2)
Shen S
(2)
Shi Y
(2)
Shook B
(2)
Siarheyeva A
(2)
Tempel W
(2)
Tong L
(2)
Vedadi M
(2)
Wang J
(2)
Wang S
(2)
Wang SM
(2)
Washburn MP
(2)
Workman JL
(2)
Wu H
(2)
 
More...
 
Homo / hetero assembly  (2)
homo
(19)
hetero
(15)
 
Assembly composition  (4)
protein structure
(19)
protein/protein complex
(10)
DNA/RNA/protein complex
(4)
DNA/protein complex
(1)
 
Assembly polymer count  (4)
monomer
(19)
dimer
(10)
35-mer
(4)
undecamer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(10)
2.0 - 2.5
(13)
2.5 - 3
(2)
3.0 - 3.5
(3)
3.5 - 4
(1)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(1)
2010 - 2015
(5)
2015 - 2020
(14)
2020 - 2025
(16)
2025 - 2030
(1)
 
Journal  (14)
ACS Chem Biol
(7)
ACS Med Chem Lett
(5)
Science
(4)
Genes Dev
(3)
Structure
(3)
J Am Chem Soc
(2)
Nat Commun
(2)
Sci Rep
(2)
Biochem Biophys Res Commun
(1)
Cell Discov
(1)
Commun Biol
(1)
Nature
(1)
Proc Natl Acad Sci U S A
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(34)
 
Organism name  (1)
Homo sapiens
(34)
 
Molecule name  (11)
HIF-1
(34)
HIP-1
(34)
Histone-lysine N-methyltransferase SETD2
(34)
Huntingtin yeast partner B
(34)
Huntingtin-interacting protein 1
(34)
Huntingtin-interacting protein B
(34)
Lysine N-methyltransferase 3A
(34)
Protein-lysine N-methyltransferase SETD2
(34)
SET domain-containing protein 2
(34)
hSET2
(34)
p231HBP
(34)
 
Molecule type  (1)
Protein
(34)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 34
Entries 1 to 10 of 34
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Structure of human SETD2 L1609P mutant in complex with SAM and H3K36M peptide
Mechaly AE, Michail C, Haouz A, Rodrigues-Lima F
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SAM    SAM    ZN    ZN   
Assembly name: Histone-lysine N-methyltransferase SETD2 and Histone H3.3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-160867 (Preferred)   search this ID
PDBe-KB: Q9BYW2    P84243   
X-ray diffraction
2.19Å resolution
Released: 5 Mar 2025
Model geometry
Fit model/data
8rzu
8rzu
8rzu
Human SETD2 bound to a nucleosome containing oncohistone mutations
Jing H, Liu Y
Cell Discov (2021) [PMID: 33972509  ]
Assembly composition: DNA/protein complex
Bound ligands: SAM    SAM    ZN    ZN   
PDBe complex ID: PDB-CPX-121237 (Preferred)   search this ID
PDBe-KB: Q9BYW2    Q6PI79    P06899    P20671    P62799   
Electron Microscopy
3.1Å resolution
Released: 14 Jul 2021
Model geometry
Fit model/data
Data not analysed
7ea8
7ea8
7ea8
Crystal structure of SETD2 bound to histone H3.3 K36M peptide
Yang S, Zheng X, Li H
Genes Dev (2016) [PMID: 27474439  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    SAH    ZN    SAH    SCN   
Assembly name: Histone-lysine N-methyltransferase SETD2 and Histone H3.3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-160867 (Preferred)   search this ID
PDBe-KB: Q9BYW2    P84243   
X-ray diffraction
2.053Å resolution
Released: 2 Nov 2016
Model geometry
Fit model/data
5jjy
5jjy
5jjy
Crystal structure of human SETD2 SET-domain in complex with H3K36M peptide and SAM
Zhang Y, Tong L
Sci Rep (2017) [PMID: 28256625  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SAM    SAM    ZN    ZN   
Assembly name: Histone-lysine N-methyltransferase SETD2 and Histone H3.1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-159442 (Preferred)   search this ID
PDBe-KB: Q9BYW2    P68431   
X-ray diffraction
2.415Å resolution
Released: 22 Mar 2017
Model geometry
Fit model/data
5v21
5v21
5v21
Crystal structure of SETD2 bound to histone H3.3 K36I peptide
Li H, Yang S
Genes Dev (2016) [PMID: 27474439  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GOL    ZN    SAH    ZN    SAH    SCN   
Assembly name: Histone-lysine N-methyltransferase SETD2 and Histone H3.3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-160867 (Preferred)   search this ID
PDBe-KB: Q9BYW2    P84243   
X-ray diffraction
1.5Å resolution
Released: 2 Nov 2016
Model geometry
Fit model/data
5jlb
5jlb
5jlb
Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives
Tisi D, Pathuri P, Heightman T
ACS Chem Biol (2016) [PMID: 27571355  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 76O    ZN    ZN   
Assembly name: Histone-lysine N-methyltransferase SETD2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189845 (Preferred)   search this ID
PDBe-KB: Q9BYW2   
X-ray diffraction
2.9Å resolution
Released: 5 Oct 2016
Model geometry
Fit model/data
5lsx
5lsx
5lsx
Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives
Tisi D, Pathuri P, Heightman T
ACS Chem Biol (2016) [PMID: 27571355  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 76L    ZN    ZN    SCN   
Assembly name: Histone-lysine N-methyltransferase SETD2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189845 (Preferred)   search this ID
PDBe-KB: Q9BYW2   
X-ray diffraction
1.51Å resolution
Released: 5 Oct 2016
Model geometry
Fit model/data
5lt7
5lt7
5lt7
Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives
Tisi D, Pathuri P, Heightman T
ACS Chem Biol (2016) [PMID: 27571355  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN    SCN    76K   
Assembly name: Histone-lysine N-methyltransferase SETD2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189845 (Preferred)   search this ID
PDBe-KB: Q9BYW2   
X-ray diffraction
1.62Å resolution
Released: 5 Oct 2016
Model geometry
Fit model/data
5lsz
5lsz
5lsz
Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives
Tisi D, Pathuri P, Heightman T
ACS Chem Biol (2016) [PMID: 27571355  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    76M    ZN    SCN   
Assembly name: Histone-lysine N-methyltransferase SETD2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189845 (Preferred)   search this ID
PDBe-KB: Q9BYW2   
X-ray diffraction
1.62Å resolution
Released: 12 Oct 2016
Model geometry
Fit model/data
5lsy
5lsy
5lsy
Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives
Tisi D, Pathuri P, Heightman T
ACS Chem Biol (2016) [PMID: 27571355  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 76J    ZN    ZN    SCN   
Assembly name: Histone-lysine N-methyltransferase SETD2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189845 (Preferred)   search this ID
PDBe-KB: Q9BYW2   
X-ray diffraction
2.05Å resolution
Released: 5 Oct 2016
Model geometry
Fit model/data
5lt6
5lt6
5lt6
Entries 1 to 10 of 34
Entries 1 to 10 of 34