Entry status  (1)

REL

(19)

Experimental methods  (3)

Electron Microscopy

(13)

Solution NMR

(4)

X-ray diffraction

(2)

Authors  (109)

Carpenter EP

(5)

Grieben M

(5)

Yu Y

(5)

DeCaen PG

(4)

Witzgall R

(4)

Arrowsmith CH

(3)

Bountra C

(3)

Cao E

(3)

Chen XZ

(3)

Edwards AM

(3)

Huiskonen JT

(3)

Pike AC

(3)

Pike ACW

(3)

Shi Y

(3)

Structural Genomics Consortium (SGC)

(3)

Su Q

(3)

Wang Z

(3)

Aryal P

(2)

Bader R

(2)

Baronina A

(2)

Besl E

(2)

Bulkley D

(2)

Buraei Z

(2)

Chen M

(2)

Chen MY

(2)

Chen X-Z

(2)

Corey RA

(2)

De Sanctis S

(2)

Esarte Palomero O

(2)

Hedger G

(2)

Heinz V

(2)

Hoffmeister H

(2)

Isacoff EY

(2)

Joos F

(2)

Kalbitzer HR

(2)

Kreuter L

(2)

Kuhlbrandt W

(2)

Kühlbrandt W

(2)

Li M-H

(2)

Li MH

(2)

Liu X

(2)

Madej MG

(2)

Morais TDC

(2)

Nasrallah C

(2)

Nazginov E

(2)

Ong AC

(2)

Ong ACM

(2)

Pillai AR

(2)

Qian F

(2)

Rhinow D

(2)

Richter RM

(2)

Ruppel S

(2)

Sansom MSP

(2)

Schmidt M

(2)

Schumann FH

(2)

Shi J

(2)

Shintre C

(2)

Tong L

(2)

Ulbrich MH

(2)

Wang Q

(2)

Wang Y

(2)

Wang ZF

(2)

Wilkes M

(2)

Yang J

(2)

Yang X

(2)

Ziegler C

(2)

Allen MD

(1)

Boggon TJ

(1)

Bulkey D

(1)

Burgess-Brown NA

(1)

Bycroft M

(1)

Cai R

(1)

Cao Y

(1)

Celic A

(1)

Chalk R

(1)

Clapham DE

(1)

Decaen PG

(1)

Ehrlich BE

(1)

El-Ajouz S

(1)

Flockerzi V

(1)

Ge X

(1)

Hodsdon ME

(1)

Hofmann L

(1)

Hu F

(1)

Hu Q

(1)

Hu R

(1)

Kennedy SD

(1)

Lei J

(1)

Mahajan P

(1)

Mei C

(1)

Mukhopadhyay S

(1)

Ng LCT

(1)

Petri ET

(1)

Qamar S

(1)

Sandford RN

(1)

Shen PS

(1)

Shintre CA

(1)

Shrestha L

(1)

Sitsapesan R

(1)

Tang J

(1)

 

More...

Homo / hetero assembly  (2)

homo

(18)

hetero

(1)

Assembly composition  (2)

protein structure

(18)

protein/protein complex

(1)

Assembly polymer count  (3)

tetramer

(13)

monomer

(4)

trimer

(2)

Resolution distribution

1.5 - 2

(2)

2.5 - 3

(6)

3.0 - 3.5

(2)

3.5 - 4

(2)

4.0 - 4.5

(3)

Release year distribution

2005 - 2010

(5)

2010 - 2015

(2)

2015 - 2020

(9)

2020 - 2025

(5)

2025 - 2030

(2)

Journal  (9)

Proc Natl Acad Sci U S A

(6)

Nat Struct Mol Biol

(3)

Biomol NMR Assign

(2)

Structure

(2)

To be published

(2)

Cell

(1)

Nat Commun

(1)

Protein Sci

(1)

Science

(1)

Organism superkingdom  (1)

Eukaryota

(19)

Organism name  (1)

Homo sapiens

(19)

Molecule name  (7)

Autosomal dominant polycystic kidney disease type II protein

(19)

PC2

(19)

Polycystic kidney disease 2 protein

(19)

Polycystin-2

(19)

Polycystwin

(19)

R48321

(19)

Transient receptor potential cation channel subfamily P member 2

(19)

Molecule type  (1)

Protein

(19)

Gene names  (3)

PKD2

(19)

TRPP1

(19)

TRPP2

(19)

Interacting Molecules  (1)

Polycystin-1

(1)

Interacting ligands  (9)

NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose

(10)

CA : CALCIUM ION

(4)

CHS : 4-AMINO-5-CYCLOHEXYL-3-HYDROXY-PENTANOIC ACID

(2)

CLR : CHOLESTEROL

(2)

PLM : PALMITIC ACID

(2)

PX6 : 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE

(2)

UMQ : UNDECYL-MALTOSIDE

(2)

AQV : 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione

(1)

PEF : DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE

(1)

Biological function  (26)

calcium ion binding

(15)

ATPase binding

(2)

HLH domain binding

(2)

actinin binding

(2)

calcium channel activity

(2)

calcium-induced calcium release activity

(2)

channel activity

(2)

cytoskeletal protein binding

(2)

identical protein binding

(2)

metal ion binding

(2)

monoatomic cation channel activity

(2)

muscle alpha-actinin binding

(2)

outward rectifier potassium channel activity

(2)

phosphoprotein binding

(2)

potassium channel activity

(2)

protein binding

(2)

protein homodimerization activity

(2)

signaling receptor binding

(2)

sodium channel activity

(2)

transcription regulator inhibitor activity

(2)

transmembrane transporter binding

(2)

voltage-gated calcium channel activity

(2)

voltage-gated monoatomic cation channel activity

(2)

voltage-gated monoatomic ion channel activity

(2)

voltage-gated potassium channel activity

(2)

voltage-gated sodium channel activity

(2)

Biological process  (62)

Wnt signaling pathway

(2)

aorta development

(2)

branching involved in ureteric bud morphogenesis

(2)

calcium ion transmembrane transport

(2)

calcium ion transport

(2)

calcium-mediated signaling

(2)

cell surface receptor signaling pathway

(2)

cell surface receptor signaling pathway via JAK-STAT

(2)

cellular response to cAMP

(2)

cellular response to calcium ion

(2)

cellular response to fluid shear stress

(2)

cellular response to hydrostatic pressure

(2)

cellular response to osmotic stress

(2)

cellular response to reactive oxygen species

(2)

centrosome duplication

(2)

cilium organization

(2)

detection of mechanical stimulus

(2)

detection of nodal flow

(2)

determination of left/right symmetry

(2)

determination of liver left/right asymmetry

(2)

embryonic placenta development

(2)

establishment of localization in cell

(2)

heart development

(2)

heart looping

(2)

inorganic cation transmembrane transport

(2)

intracellular calcium ion homeostasis

(2)

kidney development

(2)

liver development

(2)

mesonephric duct development

(2)

mesonephric tubule development

(2)

metanephric S-shaped body morphogenesis

(2)

metanephric ascending thin limb development

(2)

metanephric cortex development

(2)

metanephric cortical collecting duct development

(2)

metanephric distal tubule development

(2)

metanephric mesenchyme development

(2)

metanephric part of ureteric bud development

(2)

metanephric smooth muscle tissue development

(2)

monoatomic ion transmembrane transport

(2)

monoatomic ion transport

(2)

negative regulation of G1/S transition of mitotic cell cycle

(2)

negative regulation of cell population proliferation

(2)

neural tube development

(2)

placenta blood vessel development

(2)

positive regulation of gene expression

(2)

positive regulation of nitric oxide biosynthetic process

(2)

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

(2)

positive regulation of transcription by RNA polymerase II

(2)

potassium ion transmembrane transport

(2)

potassium ion transport

(2)

protein heterotetramerization

(2)

protein homotetramerization

(2)

protein tetramerization

(2)

regulation of calcium ion import

(2)

regulation of cell cycle

(2)

regulation of cell population proliferation

(2)

release of sequestered calcium ion into cytosol

(2)

renal artery morphogenesis

(2)

renal tubule morphogenesis

(2)

sodium ion transmembrane transport

(2)

sodium ion transport

(2)

spinal cord development

(2)

Biological cell component  (30)

membrane

(11)

Golgi apparatus

(2)

basal cortex

(2)

basal plasma membrane

(2)

basolateral plasma membrane

(2)

cation channel complex

(2)

cell projection

(2)

cell-cell junction

(2)

ciliary basal body

(2)

ciliary membrane

(2)

cilium

(2)

cytoplasm

(2)

cytoplasmic side of endoplasmic reticulum membrane

(2)

cytoplasmic vesicle

(2)

cytoplasmic vesicle membrane

(2)

cytosol

(2)

endoplasmic reticulum

(2)

endoplasmic reticulum membrane

(2)

extracellular exosome

(2)

extracellular region

(2)

lamellipodium

(2)

lumenal side of endoplasmic reticulum membrane

(2)

migrasome

(2)

mitotic spindle

(2)

monoatomic ion channel complex

(2)

motile cilium

(2)

non-motile cilium

(2)

plasma membrane

(2)

polycystin complex

(2)

vesicle

(2)

CATH class  (1)

Mainly Alpha

(5)

CATH topology  (2)

Recoverin; domain 1

(4)

Single alpha-helices involved in coiled-coils or other helix-helix interfaces

(1)

Pfam accession / name  (4)

PF00520 : Ion_trans

(13)

PF08016 : PKD_channel

(13)

PF20519 : Polycystin_dom

(13)

PF18109 : Fer4_24

(4)

Diffraction protocol  (1)

Single wavelength

(2)

Diffraction radiation source type  (2)

Rotating anode

(1)

Synchrotron

(1)

Diffraction source  (2)

NSLS BEAMLINE X4C

(1)

RIGAKU

(1)

Synchrotron site  (1)

NSLS

(1)

Diffraction detector type  (2)

CCD

(1)

Image plate

(1)

Refinement software  (3)

PHENIX

(8)

CNS

(2)

REFMAC

(1)

EM microscope model  (4)

FEI TITAN KRIOS

(7)

FEI POLARA 300

(3)

JEOL 3200FSC

(2)

TFS KRIOS

(1)

EM detector name  (3)

GATAN K2 SUMMIT (4k x 4k)

(8)

GATAN K3 (6k x 4k)

(4)

GATAN K2 IS (4k x 4k)

(1)

NMR software packages  (11)

CNS

(3)

AUREMOL

(2)

TopSpin

(2)

Auremol-ISIC

(1)

CYANA

(1)

MOLMOL

(1)

NMRDraw

(1)

NMRPipe

(1)

PSVS

(1)

Sparky

(1)

Xplor-NIH

(1)

NMR Field Strength

500.0 - 600

(4)

600.0 - 700

(4)

700.0 - 800

(3)

800.0 - 900

(3)

Representative Structures

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