Uniprot accession / id : O35664  OR   Uniprot accession / id : P48551  OR   Uniprot accession / id : C9JM33
 
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Entry Information
Entry status  (1)
REL
(9)
 
Experimental methods  (2)
Solution NMR
(5)
X-ray diffraction
(4)
 
Authors  (27)
Schreiber G
(6)
Anglister J
(5)
Garcia KC
(4)
Glenn JS
(4)
Krutzik PO
(4)
Lee C
(4)
Levin D
(4)
Levy R
(4)
Moraga I
(4)
Nolan GP
(4)
Piehler J
(4)
Podoplelova Y
(4)
Thomas C
(4)
Trejo A
(4)
Vleck SE
(4)
Yarden G
(4)
Chill JH
(3)
Akabayov SR
(2)
Nudelman I
(2)
Quadt SR
(2)
Biron Z
(1)
Kessler N
(1)
Quadt-Akabayov SR
(1)
Scherf T
(1)
Schnur E
(1)
Xu Y
(1)
Yang D
(1)
 
Homo / hetero assembly  (2)
hetero
(6)
homo
(3)
 
Assembly composition  (2)
protein/protein complex
(6)
protein structure
(3)
 
Assembly polymer count  (3)
dimer
(4)
monomer
(3)
trimer
(2)
 
Resolution distribution
1.5 - 2
(1)
2.5 - 3
(1)
3.5 - 4
(1)
4.0 - 4.5
(1)
 
Release year distribution
2000 - 2005
(2)
2005 - 2010
(2)
2010 - 2015
(6)
 
Journal  (5)
Cell
(4)
Structure
(2)
Biochemistry
(1)
J Am Chem Soc
(1)
Protein Sci
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(9)
 
Organism name  (1)
Homo sapiens
(9)
 
Molecule name  (6)
IFN-R-2
(9)
IFN-alpha binding protein
(9)
IFN-alpha/beta receptor 2
(9)
Interferon alpha binding protein
(9)
Interferon alpha/beta receptor 2
(9)
Type I interferon receptor 2
(9)
 
Molecule type  (1)
Protein
(9)
 
Gene names  (3)
IFNABR
(9)
IFNAR2
(9)
IFNARB
(9)
 
Interacting Molecules  (3)
Interferon alpha-2
(5)
Interferon alpha/beta receptor 1
(2)
Interferon omega-1
(1)
 
Interacting ligands  (1)
CL : CHLORIDE ION
(1)
 
Sequence and Structure classification
SCOP fold  (1)
Immunoglobulin-like beta-sandwich
(3)
 
SCOP family  (1)
Fibronectin type III
(3)
 
CATH class  (1)
Mainly Beta
(9)
 
CATH topology  (1)
Immunoglobulin-like
(9)
 
Pfam accession / name  (2)
PF09294 : Interfer-bind
(9)
PF01108 : Tissue_fac
(8)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(7)
 
Diffraction radiation source type  (1)
Synchrotron
(4)
 
Diffraction source  (3)
ALS BEAMLINE 8.2.2
(2)
ALS BEAMLINE 8.2.1
(1)
SSRL BEAMLINE BL9-2
(1)
 
Synchrotron site  (2)
ALS
(3)
SSRL
(1)
 
Diffraction detector type  (1)
CCD
(4)
 
Refinement software  (1)
PHENIX
(4)
 
NMR
NMR software packages  (6)
NMRPipe
(4)
XwinNMR
(4)
HADDOCK
(3)
CNS
(2)
NMRView
(2)
TopSpin
(1)
 
NMR Field Strength
400.0 - 500
(3)
500.0 - 600
(3)
700.0 - 800
(5)
800.0 - 900
(5)
 
Representative Structures
Representative Structures
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Entries 1 to 9 of 9
Entries 1 to 9 of 9
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Structure of the 44 kDa complex of interferon-alpha2 with the extracellular part of IFNAR2 obtained by 2D-double difference NOESY
Nudelman I, Akabayov SR, Scherf T, Anglister J
J Am Chem Soc (2011) [PMID: 21819146  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Interferon alpha/beta receptor 2 and Interferon alpha-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-134393 (Preferred)   search this ID
PDBe-KB: P48551    P01563    P48551   
Solution NMR
Released: 17 Aug 2011
Model geometry
Fit model/data
Data not analysed
2lag
2lag
2lag
NMR based Docking Model of the Complex between the Human Type I Interferon Receptor and Human Interferon alpha-2
Quadt-Akabayov SR, Chill JH, Levy R, Kessler N, Anglister J
Protein Sci (2006) [PMID: 17001036  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Interferon alpha/beta receptor 2 and Interferon alpha-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-134393 (Preferred)   search this ID
PDBe-KB: P48551    P48551    P01563   
Solution NMR
Released: 10 Oct 2006
Model geometry
Fit model/data
Data not analysed
2hym
2hym
2hym
Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY
Nudelman I, Akabayov SR, Schnur E, Biron Z, Levy R, Xu Y, Yang D, Anglister J
Biochemistry (2010) [PMID: 20496919  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Interferon alpha/beta receptor 2 and Interferon alpha-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-134393 (Preferred)   search this ID
PDBe-KB: P48551    P01563    P48551   
Solution NMR
Released: 23 Jun 2010
Model geometry
Fit model/data
Data not analysed
2kz1
2kz1
2kz1
Average structure of the interferon-binding ectodomain of the human type I interferon receptor
Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J
Structure (2003) [PMID: 12842042  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Interferon alpha/beta receptor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155758 (Preferred)   search this ID
PDBe-KB: P48551   
Solution NMR
Released: 15 Jul 2003
Model geometry
Data not analysed
Fit model/data
Data not analysed
1n6v
1n6v
1n6v
NMR structure of the interferon-binding ectodomain of the human interferon receptor
Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J
Structure (2003) [PMID: 12842042  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Interferon alpha/beta receptor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155758 (Preferred)   search this ID
PDBe-KB: P48551   
Solution NMR
Released: 15 Jul 2003
Model geometry
Fit model/data
Data not analysed
1n6u
1n6u
1n6u
binary complex between IFNa2 and IFNAR2
Thomas C, Garcia KC
Cell (2011) [PMID: 21854986  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CL   
Assembly name: Interferon alpha/beta receptor 2 and Interferon alpha-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-134393 (Preferred)   search this ID
PDBe-KB: P48551    P01563   
X-ray diffraction
1.9999Å resolution
Released: 31 Aug 2011
Model geometry
Fit model/data
3s9d
3s9d
3s9d
D2 domain of human IFNAR2
Thomas C, Garcia KC
Cell (2011) [PMID: 21854986  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CL   
Modified residues: MSE    MSE   
Assembly name: Interferon alpha/beta receptor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155758 (Preferred)   search this ID
PDBe-KB: P48551   
X-ray diffraction
2.6Å resolution
Released: 31 Aug 2011
Model geometry
Fit model/data
3s8w
3s8w
3s8w
human IFNw-IFNAR ternary complex
Thomas C, Garcia KC
Cell (2011) [PMID: 21854986  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Assembly name: Interferon omega receptor-ligand complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-138311 (Preferred)   search this ID
PDBe-KB: P48551    P05000    P17181   
X-ray diffraction
3.5001Å resolution
Released: 31 Aug 2011
Model geometry
Fit model/data
3se4
3se4
3se4
human IFNa2-IFNAR ternary complex
Thomas C, Garcia KC
Cell (2011) [PMID: 21854986  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Assembly name: Interferon alpha receptor-ligand complex, IFNA2 variant (Preferred)   search this complex
PDBe complex ID: PDB-CPX-134392 (Preferred)   search this ID
PDBe-KB: P48551    P17181    P01563   
X-ray diffraction
4.0001Å resolution
Released: 31 Aug 2011
Model geometry
Fit model/data
3se3
3se3
3se3
Entries 1 to 9 of 9
Entries 1 to 9 of 9