Uniprot accession / id : O54829  OR   Uniprot accession / id : P49802
 
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Entry Information
Entry status  (1)
REL
(5)
 
Experimental methods  (3)
Electron Microscopy
(3)
Solution NMR
(1)
X-ray diffraction
(1)
 
Authors  (48)
Cho Y
(2)
Jeong E
(2)
Jeong J
(2)
Kim Y
(2)
Arrowsmith C
(1)
Ball LJ
(1)
Debreczeni J
(1)
Dowler EF
(1)
Doyle DA
(1)
Edwards A
(1)
Elkins JM
(1)
Fedorov OY
(1)
Gileadi C
(1)
Gileadi O
(1)
Griffin PR
(1)
Hayashi F
(1)
Higman VA
(1)
Hunt JF
(1)
Hutsell SQ
(1)
Izard T
(1)
Johansson C
(1)
Kimple AJ
(1)
Laboute T
(1)
Martemyanov KA
(1)
Nagashima T
(1)
Nagasima T
(1)
Novick SJ
(1)
Patil DN
(1)
Phillips C
(1)
Qiu X
(1)
RIKEN Structural Genomics/Proteomics Initiative (RSGI)
(1)
Robinson CV
(1)
Schoch GA
(1)
Siderovski DP
(1)
Singh AK
(1)
Singh S
(1)
Smee C
(1)
Soundararajan M
(1)
Structural Genomics Consortium (SGC)
(1)
Strutzenberg TS
(1)
Sundstrom M
(1)
Sundström M
(1)
Turnbull AP
(1)
Willard FS
(1)
Wu D
(1)
Yokoyama S
(1)
Zhang HP
(1)
von Delft F
(1)
 
Homo / hetero assembly  (2)
hetero
(3)
homo
(2)
 
Assembly composition  (2)
protein/protein complex
(3)
protein structure
(2)
 
Assembly polymer count  (4)
tetramer
(2)
dimer
(1)
hexamer
(1)
monomer
(1)
 
Resolution distribution
1.5 - 2
(1)
3.0 - 3.5
(1)
4.0 - 4.5
(1)
4.5 - 5
(1)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(2)
2020 - 2025
(3)
 
Journal  (4)
Nat Commun
(2)
Proc Natl Acad Sci U S A
(1)
Science
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(5)
 
Organism name  (1)
Homo sapiens
(5)
 
Molecule name  (2)
RGS7
(5)
Regulator of G-protein signaling 7
(5)
 
Molecule type  (1)
Protein
(5)
 
Gene names  (1)
RGS7
(5)
 
Interacting Molecules  (2)
Guanine nucleotide-binding protein subunit beta-5
(3)
Metabotropic glycine receptor
(3)
 
Interacting ligands  (1)
CL : CHLORIDE ION
(1)
 
Function and Biology
Biological function  (4)
G-protein alpha-subunit binding
(3)
G-protein beta-subunit binding
(3)
GTPase activator activity
(3)
GTPase activity
(3)
 
Biological process  (7)
regulation of G protein-coupled receptor signaling pathway
(5)
G protein-coupled receptor signaling pathway
(3)
intracellular signal transduction
(3)
negative regulation of G protein-coupled receptor signaling pathway
(3)
negative regulation of signal transduction
(3)
positive regulation of GTPase activity
(3)
regulation of postsynaptic membrane potential
(3)
 
Biological cell component  (13)
cell tip
(3)
cytoplasm
(3)
cytosol
(3)
dendrite
(3)
dendrite terminus
(3)
glutamatergic synapse
(3)
membrane
(3)
neuron projection
(3)
nucleus
(3)
plasma membrane
(3)
postsynaptic membrane
(3)
presynapse
(3)
presynaptic membrane
(3)
 
Sequence and Structure classification
CATH class  (1)
Mainly Alpha
(2)
 
CATH topology  (2)
Regulator of G-protein Signalling 4; domain 2
(2)
Regulator of G-protein Signalling 4; domain 1
(1)
 
Pfam accession / name  (4)
PF00615 : RGS
(5)
PF00610 : DEP
(3)
PF00631 : G-gamma
(3)
PF18148 : RGS_DHEX
(3)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(1)
 
Diffraction radiation source type  (1)
Rotating anode
(1)
 
Diffraction source  (1)
RIGAKU FR-E DW
(1)
 
Diffraction detector type  (1)
Image plate
(1)
 
Refinement software  (2)
PHENIX
(2)
REFMAC
(1)
 
EM microscope model  (2)
FEI TALOS ARCTICA
(2)
FEI TITAN KRIOS
(1)
 
EM detector name  (1)
GATAN K3 (6k x 4k)
(3)
 
NMR
NMR software packages  (5)
CYANA
(1)
KUJIRA
(1)
NMRPipe
(1)
NMRView
(1)
VNMR
(1)
 
NMR Field Strength
700.0 - 800
(1)
800.0 - 900
(1)
900.0 - 1000
(1)
 
Representative Structures
Representative Structures
100%
95%
90%
70%
50%
40%
30%
Entries 1 to 5 of 5
Entries 1 to 5 of 5
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Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:1:1 ratio
Kim Y, Jeong E, Jeong J, Cho Y
Nat Commun (2021) [PMID: 34815401  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-127122 (Preferred)   search this ID
PDBe-KB: P49802    O14775    Q5T848   
Electron Microscopy
4.3Å resolution
Released: 1 Dec 2021
Model geometry
Fit model/data
Data not analysed
7ewp
7ewp
7ewp
Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:2:2 ratio
Kim Y, Jeong E, Jeong J, Cho Y
Nat Commun (2021) [PMID: 34815401  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-127123 (Preferred)   search this ID
PDBe-KB: P49802    O14775    Q5T848   
Electron Microscopy
4.7Å resolution
Released: 1 Dec 2021
Model geometry
Fit model/data
Data not analysed
7ewr
7ewr
7ewr
Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex
Patil DN, Singh S, Singh AK, Martemyanov KA
Science (2022) [PMID: 34793198  ]
Assembly composition: protein/protein complex
Bound ligands: CLR    PEE    CLR    EIJ    EIJ    PEE   
PDBe complex ID: PDB-CPX-156050 (Preferred)   search this ID
PDBe-KB: P49802    P62881    Q5T848    P49802   
Electron Microscopy
3.4Å resolution
Released: 1 Dec 2021
Model geometry
Fit model/data
Data not analysed
7shf
7shf
7shf
Structure of the regulator of G-protein signaling domain of RGS7
Schoch GA, Johansson C, Phillips C, Debreczeni J, Smee C, Elkins JM, Sundstrom M, Edwards A, Arrowsmith C, von Delft F, Gileadi O, Doyle DA, Structural Genomics Consortium (SGC)
Proc Natl Acad Sci U S A (2008) [PMID: 18434541  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CL   
Assembly name: Regulator of G-protein signaling 7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-156051 (Preferred)   search this ID
PDBe-KB: P49802   
X-ray diffraction
2Å resolution
Released: 12 Jul 2005
Model geometry
Fit model/data
2a72
2a72
2a72
Solution structure of the RGS domain of Regulator of G-protein signaling 7
Zhang HP, Nagasima T, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Regulator of G-protein signaling 7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-156049 (Preferred)   search this ID
PDBe-KB: P49802   
Solution NMR
Released: 9 Dec 2006
Model geometry
Fit model/data
Data not deposited
2d9j
2d9j
2d9j
Entries 1 to 5 of 5
Entries 1 to 5 of 5