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Entry Information
Entry status
(1)
Experimental methods
(2)
Electron Microscopy
(19)
Solution NMR
(1)
Authors
(27)
Cho HJ
(14)
Lee HH
(14)
Chung DK
(7)
Jeong H
(7)
Kim M
(7)
Lee HJ
(7)
Lee SN
(7)
Ryu B
(7)
Woo JS
(7)
Yoo J
(7)
Blum TB
(4)
Ding XY
(4)
Korkhov VM
(4)
Aureli S
(3)
Ding X
(3)
Gervasio FL
(3)
Khanppnavar B
(3)
Lavriha P
(3)
Li X
(3)
Picotti P
(3)
Schuster D
(3)
Vaithia A
(3)
Chen S
(1)
Chen SS
(1)
Donaldson L
(1)
Mao W
(1)
Mao WX
(1)
Homo / hetero assembly
(1)
homo
(20)
Assembly composition
(1)
protein structure
(20)
Assembly polymer count
(2)
dodecamer
(19)
monomer
(1)
Resolution distribution
2.0 - 2.5
(3)
2.5 - 3
(10)
3.0 - 3.5
(5)
3.5 - 4
(1)
Release year distribution
2010 - 2015
(1)
2015 - 2020
(1)
2020 - 2025
(19)
Journal
(4)
Nat Commun
(14)
Cell Discov
(3)
To be published
(2)
Arch Biochem Biophys
(1)
Macromolecules
Organism superkingdom
(2)
Eukaryota
(20)
Bacteria
(2)
Organism name
(2)
Homo sapiens
(20)
Escherichia coli
(2)
Molecule name
(7)
Connexin-36
(20)
Cx36
(20)
Gap junction alpha-9 protein
(20)
Gap junction delta-2 protein
(20)
Cytochrome b-562
(2)
Soluble cytochrome b562
(2)
Calmodulin-1
(1)
Molecule type
(1)
Protein
(20)
Gene names
(7)
GJA9
(20)
GJD2
(20)
cybC
(2)
CALM
(1)
CALM1
(1)
CAM
(1)
CAM1
(1)
Interacting ligands
(11)
MC3 : 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE
(12)
Y01 : CHOLESTEROL HEMISUCCINATE
(3)
YMZ : (11R,12S)- Mefloquine
(2)
ACD : ARACHIDONIC ACID
(1)
AV0 : Lauryl Maltose Neopentyl Glycol
(1)
CA : CALCIUM ION
(1)
HE2 : HEXAN-1-OL
(1)
LHG : 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE
(1)
LMT : DODECYL-BETA-D-MALTOSIDE
(1)
QDN : Quinidine
(1)
QI9 : Quinine
(1)
Function and Biology
Biological function
(17)
gap junction channel activity
(17)
metal ion binding
(3)
electron transfer activity
(2)
heme binding
(2)
iron ion binding
(2)
adenylate cyclase activator activity
(1)
calcium channel inhibitor activity
(1)
calcium channel regulator activity
(1)
calcium ion binding
(1)
calcium-dependent protein binding
(1)
protein binding
(1)
protein kinase binding
(1)
protein phosphatase activator activity
(1)
protein serine/threonine kinase activator activity
(1)
titin binding
(1)
transmembrane transporter binding
(1)
transporter inhibitor activity
(1)
Biological process
(33)
cell communication
(19)
cell-cell signaling
(17)
chemical synaptic transmission
(17)
neuronal action potential
(17)
transmembrane transport
(17)
visual perception
(17)
electron transport chain
(2)
G protein-coupled receptor signaling pathway
(1)
G2/M transition of mitotic cell cycle
(1)
autophagosome membrane docking
(1)
calcineurin-mediated signaling
(1)
cellular response to interferon-beta
(1)
cellular response to type II interferon
(1)
detection of calcium ion
(1)
long-term synaptic potentiation
(1)
mitochondrion-endoplasmic reticulum membrane tethering
(1)
negative regulation of calcium ion export across plasma membrane
(1)
negative regulation of high voltage-gated calcium channel activity
(1)
negative regulation of ryanodine-sensitive calcium-release channel activity
(1)
organelle localization by membrane tethering
(1)
positive regulation of receptor signaling pathway via JAK-STAT
(1)
presynaptic endocytosis
(1)
regulation of calcium-mediated signaling
(1)
regulation of cardiac muscle cell action potential
(1)
regulation of cardiac muscle contraction
(1)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
(1)
regulation of cell communication by electrical coupling involved in cardiac conduction
(1)
regulation of cytokinesis
(1)
regulation of heart rate
(1)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
(1)
regulation of ryanodine-sensitive calcium-release channel activity
(1)
response to calcium ion
(1)
substantia nigra development
(1)
Biological cell component
(30)
connexin complex
(19)
membrane
(18)
plasma membrane
(18)
anchoring junction
(17)
gap junction
(17)
synapse
(17)
periplasmic space
(2)
calcium channel complex
(1)
calyx of Held
(1)
catalytic complex
(1)
cell projection
(1)
centrosome
(1)
cilium
(1)
cytoplasm
(1)
cytoskeleton
(1)
cytosol
(1)
extracellular region
(1)
motile cilium
(1)
myelin sheath
(1)
nucleoplasm
(1)
nucleus
(1)
presynaptic cytosol
(1)
protein-containing complex
(1)
sarcomere
(1)
sperm midpiece
(1)
spindle
(1)
spindle microtubule
(1)
spindle pole
(1)
vesicle
(1)
voltage-gated potassium channel complex
(1)
Sequence and Structure classification
Pfam accession / name
(3)
PF00029 : Connexin
(19)
PF07361 : Cytochrom_B562
(2)
PF13499 : EF-hand_7
(1)
Experimental Information
Refinement software
(2)
PHENIX
(6)
phenix.real_space_refine
(1)
EM microscope model
(3)
FEI TITAN KRIOS
(14)
TFS KRIOS
(3)
TFS GLACIOS
(2)
EM detector name
(4)
GATAN K3 BIOQUANTUM (6k x 4k)
(6)
GATAN K3 (6k x 4k)
(5)
FEI FALCON III (4k x 4k)
(4)
FEI FALCON IV (4k x 4k)
(4)
NMR
NMR software packages
(3)
CYANA
(1)
NMRPipe
(1)
PHENIX
(1)
NMR Field Strength
600.0 - 700
(1)
700.0 - 800
(1)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 20
Select all entries on this page
human connexin-36 gap junction channel
Ding XY, Blum TB, Korkhov VM
Cell Discov
(2024)
[PMID: 38890333 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Gap junction delta-2 protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-193853 (Preferred)
search this ID

human connexin-36 gap junction channel in complex with quinine
Ding XY, Blum TB, Korkhov VM
Cell Discov
(2024)
[PMID: 38890333 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Gap junction delta-2 protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-193853 (Preferred)
search this ID

human connexin36 gap junction channel in complex with quinidine
Ding XY, Blum TB, Korkhov VM
To be published
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Gap junction delta-2 protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-193853 (Preferred)
search this ID

human connexin-36 gap junction channel in complex with mefloquine
Ding XY, Blum TB, Korkhov VM
Cell Discov
(2024)
[PMID: 38890333 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Bound ligands:
YMZ
Assembly name:
Gap junction delta-2 protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-193853 (Preferred)
search this ID

Human neuronal gap junction channel connexin 36
Mao WX, Chen SS
Arch Biochem Biophys
(2024)
[PMID: 38490311 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Gap junction delta-2 protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-193853 (Preferred)
search this ID

Human Cx36/GJD2 gap junction channel in complex with arachidonic acid.
Cho HJ, Lee HH
Nat Commun
(2024)
[PMID: 39455592 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Gap junction delta-2 protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-193853 (Preferred)
search this ID

Human Cx36/GJD2 gap junction channel in porcine brain lipids.
Cho HJ, Lee HH
Nat Commun
(2024)
[PMID: 39455592 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Gap junction delta-2 protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-193853 (Preferred)
search this ID

Human Cx36/GJD2 (Ala14-deleted mutant) gap junction channel in porcine brain lipids
Cho HJ, Lee HH
Nat Commun
(2024)
[PMID: 39455592 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Gap junction delta-2 protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-193853 (Preferred)
search this ID

Human Cx36/GJD2 gap junction channel in complex with mefloquine.
Cho HJ, Lee HH
Nat Commun
(2024)
[PMID: 39455592 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Gap junction delta-2 protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-193853 (Preferred)
search this ID

Human Cx36/GJD2 (Ala14 deletion mutant) gap junction channel prepared with mefloquine, showing no bound mefloquine
Cho HJ, Lee HH
Nat Commun
(2024)
[PMID: 39455592 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Gap junction delta-2 protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-193853 (Preferred)
search this ID

Entries 1 to 10 of 20