Uniprot accession / id : O54974  OR   Uniprot accession / id : P47929
 
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Entry Information
Entry status  (1)
REL
(35)
 
Experimental methods  (1)
X-ray diffraction
(35)
 
Authors  (56)
Calmettes C
(18)
Doucet N
(18)
Pham NTH
(18)
Acharya KR
(11)
Masuyer G
(6)
Al-Abdul-Wahid MS
(5)
Begin G
(5)
Bégin G
(5)
Celis JE
(5)
Chatenet D
(5)
Folch B
(5)
Fortier M
(5)
Lague P
(5)
Lagüe P
(5)
Leonidas DD
(5)
Letourneau M
(5)
Létourneau M
(5)
Madsen P
(5)
Pucci F
(5)
Rooman M
(5)
St-Pierre Y
(5)
Vatzaki EH
(5)
Vorum H
(5)
Arbez-Gindre C
(4)
Calogeropoulou T
(4)
Haj Sleiman M
(4)
Hsieh TJ
(4)
Lin CH
(4)
Lin HY
(4)
Micha-Screttas M
(4)
Ramaswamy S
(4)
Sleiman MH
(4)
Steele BR
(4)
Tu Z
(4)
Wu SC
(4)
Hsu ST
(3)
Cai J
(2)
Danny Hsu ST
(2)
Huang BS
(2)
Huang J
(2)
Jabeen T
(2)
Leffler H
(2)
Liang Y
(2)
Lin TC
(2)
Liu FT
(2)
Nilsson UJ
(2)
Oberg CT
(2)
Shi A
(2)
Si Y
(2)
Si YL
(2)
Tseng YY
(2)
Wang Y
(2)
Zhu Q
(2)
Zhu X
(2)
Öberg CT
(2)
Chien CT
(1)
 
Homo / hetero assembly  (2)
homo
(33)
hetero
(2)
 
Assembly composition  (2)
protein structure
(33)
protein/protein complex
(2)
 
Assembly polymer count  (2)
dimer
(27)
monomer
(8)
 
Resolution distribution
1.0 - 1.5
(2)
1.5 - 2
(22)
2.0 - 2.5
(8)
2.5 - 3
(3)
 
Release year distribution
1995 - 2000
(5)
2010 - 2015
(7)
2015 - 2020
(4)
2020 - 2025
(20)
 
Journal  (7)
To be published
(14)
FEBS J
(6)
Biochemistry
(5)
J Biol Chem
(5)
Int J Mol Sci
(2)
Sci Rep
(2)
PLoS One
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(35)
 
Organism name  (1)
Homo sapiens
(35)
 
Molecule name  (5)
Gal-7
(35)
Galectin-7
(35)
HKL-14
(35)
PI7
(35)
p53-induced gene 1 protein
(35)
 
Molecule type  (1)
Protein
(35)
 
Gene names  (3)
LGALS7
(35)
LGALS7B
(35)
PIG1
(35)
 
Interacting Molecules  (1)
Galectin-7
(2)
 
Interacting ligands  (20)
GOL : GLYCEROL
(14)
GAL : beta-D-galactopyranose
(12)
EDO : 1,2-ETHANEDIOL
(10)
GLC : alpha-D-glucopyranose
(6)
PRD_900008 : alpha-lactose
(6)
PEG : DI(HYDROXYETHYL)ETHER
(3)
TRS : 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
(3)
4S0 : DENDRON D2-1
(2)
BGC : beta-D-glucopyranose
(2)
LBL : (2~{R},3~{R},4~{R},5~{R})-4-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-2,3,5, 6-tetrakis(oxidanyl)hexanal
(2)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(2)
PRD_900004 : beta-lactose
(2)
1GN : 2-amino-2-deoxy-beta-D-galactopyranose
(1)
50G : DENDRON-D1
(1)
6S2 : methyl 2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranoside
(1)
ACT : ACETATE ION
(1)
PGZ : METHYL 2-O-[(S)-(BENZYLOXY)(HYDROXY)PHOSPHORYL]-3-DEOXY-3-{[(4-METHYLPHENYL)CARBONYL]AMINO}-1-THIO-BETA-D-GALACTOPYRANOSIDE
(1)
TD2 : 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside
(1)
TGZ : (2~{S},3~{R},4~{S},5~{R},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,4,5-triol
(1)
VV7 : DENDRON-D3
(1)
 
Function and Biology
Biological function  (2)
carbohydrate binding
(35)
protein binding
(35)
 
Biological process  (2)
apoptotic process
(35)
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
(35)
 
Biological cell component  (5)
cytoplasm
(35)
extracellular exosome
(35)
extracellular region
(35)
extracellular space
(35)
nucleus
(35)
 
Sequence and Structure classification
SCOP fold  (1)
Concanavalin A-like lectins/glucanases
(5)
 
SCOP family  (1)
Galectin (animal S-lectin)
(5)
 
CATH class  (1)
Mainly Beta
(15)
 
CATH topology  (1)
Jelly Rolls
(15)
 
Pfam accession / name  (1)
PF00337 : Gal-bind_lectin
(35)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(30)
 
Diffraction radiation source type  (1)
Synchrotron
(35)
 
Diffraction source  (13)
CLSI BEAMLINE 08B1-1
(13)
CLSI BEAMLINE 08ID-1
(5)
DIAMOND BEAMLINE I04
(3)
DIAMOND BEAMLINE I03
(2)
EMBL/DESY, HAMBURG BEAMLINE BW7B
(2)
NSRRC BEAMLINE BL13C1
(2)
SSRF BEAMLINE BL18U1
(2)
DIAMOND BEAMLINE I04-1
(1)
EMBL/DESY, HAMBURG BEAMLINE X11
(1)
NSRRC BEAMLINE BL13B1
(1)
NSRRC BEAMLINE BL15A1
(1)
SRS BEAMLINE PX9.5
(1)
SRS BEAMLINE PX9.6
(1)
 
Synchrotron site  (6)
CLSI
(18)
Diamond
(6)
NSRRC
(4)
EMBL/DESY, Hamburg
(3)
SRS
(2)
SSRF
(2)
 
Diffraction detector type  (3)
CCD
(18)
Pixel
(12)
Image plate
(5)
 
Refinement software  (3)
PHENIX
(28)
X-PLOR
(5)
REFMAC
(2)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 35
Entries 1 to 10 of 35
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH N-ACETYLLACTOSAMINE
Leonidas DD, Acharya KR
Biochemistry (1998) [PMID: 9760227  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Carbohydrate polymer components:
Molecule 1 - GAL(1), NAG(1)
Assembly name: Galectin-7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155680 (Preferred)   search this ID
PDBe-KB: P47929   
X-ray diffraction
2Å resolution
Released: 4 Nov 1998
Model geometry
Fit model/data
Data not deposited
5gal
5gal
5gal
Crystal Structure of Human Galectin-7 in Complex with TAZTDG
Hsieh TJ, Lin HY, Lin CH
Sci Rep (2016) [PMID: 27416897  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: TGZ   
Assembly name: Galectin-7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155680 (Preferred)   search this ID
PDBe-KB: P47929   
X-ray diffraction
1.821Å resolution
Released: 29 Jun 2016
Model geometry
Fit model/data
5h9s
5h9s
5h9s
Crystal Structure of Human Galectin-7 in Complex with TD139
Hsieh TJ, Lin HY, Lin CH
Sci Rep (2016) [PMID: 27416897  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: TD2    TD2   
Assembly name: Galectin-7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155680 (Preferred)   search this ID
PDBe-KB: P47929   
X-ray diffraction
1.931Å resolution
Released: 29 Jun 2016
Model geometry
Fit model/data
5h9q
5h9q
5h9q
Crystal structure of R22A human Galectin-7 mutant
Pham NTH, Calmettes C, Doucet N
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PEG    GOL    PEG    TRS    EDO    TRS   
Assembly name: Galectin-7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155680 (Preferred)   search this ID
PDBe-KB: P47929   
X-ray diffraction
2.1Å resolution
Released: 25 Jan 2023
Model geometry
Fit model/data
7n6c
7n6c
7n6c
Crystal structure of R20A-R22A human Galectin-7 mutant
Pham NTH, Calmettes C, Doucet N
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    TRS    EDO    TRS   
Assembly name: Galectin-7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155680 (Preferred)   search this ID
PDBe-KB: P47929   
X-ray diffraction
1.95Å resolution
Released: 25 Jan 2023
Model geometry
Fit model/data
7n8g
7n8g
7n8g
Crystal structure of R22A human Galectin-7 mutant in presence of Lactose
Pham NTH, Calmettes C, Doucet N
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: EDO   
Modified residues: CSO    CSO   
Carbohydrate polymer components:
Molecule 1 - GAL(1), GLC(1)
Assembly name: Galectin-7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155679 (Preferred)   search this ID
PDBe-KB: P47929   
X-ray diffraction
2.49Å resolution
Released: 25 Jan 2023
Model geometry
Fit model/data
7n8d
7n8d
7n8d
Crystal structure of R20A human Galectin-7 mutant in presence of lactose
Pham NTH, Calmettes C, Doucet N
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL    EDO   
Carbohydrate polymer components:
Molecule 1 - GAL(1), GLC(1)
Assembly name: Galectin-7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155680 (Preferred)   search this ID
PDBe-KB: P47929   
X-ray diffraction
1.83Å resolution
Released: 25 Jan 2023
Model geometry
Fit model/data
7n57
7n57
7n57
Crystal structure of D103A human Galectin-7 mutant
Pham NTH, Calmettes C, Doucet N
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL   
Assembly name: Galectin-7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155680 (Preferred)   search this ID
PDBe-KB: P47929   
X-ray diffraction
2.38Å resolution
Released: 25 Jan 2023
Model geometry
Fit model/data
7n96
7n96
7n96
Crystal structure of human Galectin-7 in complex with 4-O-beta-D-Galactopyranosyl-D-glucose
Pham NTH, Calmettes C, Doucet N
J Biol Chem (2021) [PMID: 34673030  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: LBL   
Assembly name: Galectin-7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155680 (Preferred)   search this ID
PDBe-KB: P47929   
X-ray diffraction
1.69Å resolution
Released: 25 Aug 2021
Model geometry
Data not analysed
Fit model/data
Data not analysed
6vto
6vto
6vto
Crystal structure of G16C human Galectin-7 mutant in complex with lactose
Pham NTH, Calmettes C, Doucet N
J Biol Chem (2021) [PMID: 34673030  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL   
Modified residues: CSO    CSO   
Carbohydrate polymer components:
Molecule 1 - GAL(1), GLC(1)
Assembly name: Galectin-7 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-155680 (Preferred)   search this ID
PDBe-KB: P47929   
X-ray diffraction
1.95Å resolution
Released: 25 Aug 2021
Model geometry
Fit model/data
6vtq
6vtq
6vtq
Entries 1 to 10 of 35
Entries 1 to 10 of 35