Entry status  (1)

REL

(105)

Experimental methods  (2)

Electron Microscopy

(81)

X-ray diffraction

(24)

Authors  (288)

Mao Y

(32)

Lu Y

(27)

Finley D

(25)

Zhu Y

(22)

Ouyang Q

(20)

Wu Z

(20)

Zhang S

(20)

Wang WL

(14)

Chen S

(13)

Yin D

(13)

Zhao L

(13)

Zou S

(13)

Chari A

(12)

Henneberg F

(12)

Wang Y

(12)

Groll M

(11)

Heinemeyer W

(11)

Huber EM

(11)

Schrader J

(11)

Stark H

(11)

Bourenkov G

(10)

Mata R

(10)

Mata RA

(10)

Schneider TR

(10)

Tittmann K

(10)

Zhang H

(10)

Huang L

(9)

Overkleeft HS

(9)

Wang X

(9)

Zhao J

(9)

Zhou C

(9)

de Bruin G

(9)

Cheng Y

(8)

Colson L

(8)

Goldberg AL

(8)

Huang B

(8)

Lee D

(8)

Makhija S

(8)

Muralidharan M

(8)

Tkacik E

(8)

Dong Y

(7)

Li X

(7)

Mao YD

(7)

Stoilova-McPhie S

(7)

Wu J

(7)

Yu D

(7)

Finley DJ

(5)

Kirschner MW

(5)

Lee BH

(5)

Ma YB

(5)

Yu Z

(5)

Adolf F

(4)

Du J

(4)

Goodall EA

(4)

Hanna J

(4)

Hanna JW

(4)

Harper JW

(4)

Rawson S

(4)

Rawson SD

(4)

Schulman BA

(4)

Walsh Jr RM

(4)

Walsh RM

(4)

von Gronau S

(4)

Arkinson C

(3)

Brik A

(3)

Cong Y

(3)

Day S

(3)

Ding Z

(3)

Dong KC

(3)

Gee CL

(3)

Glickman MH

(3)

Han Q

(3)

Han Y

(3)

Kleifeld O

(3)

Liu K

(3)

Mali SM

(3)

Martin A

(3)

Morag R

(3)

Rozenberg A

(3)

Sahoo MP

(3)

Sahu I

(3)

Singh SK

(3)

Sulkshane P

(3)

Tang Q

(3)

Xu C

(3)

Zhang Y

(3)

Zhang Z

(3)

Arai Y

(2)

Basler M

(2)

Baumeister W

(2)

Beck F

(2)

Chen X

(2)

Chopra N

(2)

Diedrich C

(2)

Dorris Z

(2)

Fox T

(2)

Gamo FJ

(2)

Groettrup M

(2)

Harshbarger W

(2)

Harshbarger WH

(2)

 

More...

Homo / hetero assembly  (1)

hetero

(105)

Assembly composition  (1)

protein/protein complex

(105)

Assembly polymer count  (17)

28-mer

(34)

46-mer

(15)

48-mer

(10)

34-mer

(7)

47-mer

(7)

49-mer

(7)

32-mer

(6)

30-mer

(4)

29-mer

(3)

35-mer

(3)

64-mer

(2)

heptadecamer

(2)

21-mer

(1)

33-mer

(1)

42-mer

(1)

hexadecamer

(1)

pentadecamer

(1)

Resolution distribution

1.5 - 2

(5)

2.0 - 2.5

(8)

2.5 - 3

(30)

3.0 - 3.5

(29)

3.5 - 4

(13)

4.0 - 4.5

(9)

4.5 - 5

(4)

5.5 - 6

(2)

6.5 - 7

(3)

7.5 - 8

(2)

Release year distribution

2010 - 2015

(5)

2015 - 2020

(53)

2020 - 2025

(54)

2025 - 2030

(4)

Journal  (15)

Nature

(21)

Proc Natl Acad Sci U S A

(16)

Nat Commun

(15)

Mol Cell

(10)

Science

(10)

EMBO J

(9)

Nat Struct Mol Biol

(6)

Structure

(4)

bioRxiv

(4)

Sci Adv

(3)

Bioorg Med Chem

(2)

Cell

(2)

ACS Chem Biol

(1)

Mol Cell Proteomics

(1)

PLoS Biol

(1)

Organism superkingdom  (1)

Eukaryota

(105)

Organism name  (3)

Homo sapiens

(101)

Saccharomyces cerevisiae S288C

(9)

Mus musculus

(4)

Molecule name  (13)

Macropain epsilon chain

(105)

Multicatalytic endopeptidase complex epsilon chain

(105)

Proteasome chain 6

(105)

Proteasome epsilon chain

(105)

Proteasome subunit X

(105)

Proteasome subunit beta type-5

(105)

Proteasome subunit beta-5

(105)

beta-5

(105)

Proteasome subunit MB1

(101)

Macropain subunit PRE2

(9)

Multicatalytic endopeptidase complex subunit PRE2

(9)

Proteasome component PRE2

(9)

Proteinase YSCE subunit PRE2

(9)

Molecule type  (1)

Protein

(105)

Gene names  (10)

LMPX

(101)

MB1

(101)

PSMB5

(101)

X

(101)

DOA3

(9)

P8283.10

(9)

PRE2

(9)

PRG1

(9)

YPR103W

(9)

Psmb5

(4)

Interacting Molecules  (58)

Proteasome subunit alpha type-1

(105)

Proteasome subunit alpha type-2

(105)

Proteasome subunit alpha type-3

(105)

Proteasome subunit alpha type-4

(105)

Proteasome subunit alpha type-5

(105)

Proteasome subunit alpha type-6

(105)

Proteasome subunit beta type-1

(105)

Proteasome subunit beta type-2

(105)

Proteasome subunit beta type-3

(105)

Proteasome subunit beta type-7

(105)

Proteasome subunit beta type-4

(104)

Proteasome subunit beta type-6

(104)

Proteasome subunit alpha type-7

(96)

26S proteasome regulatory subunit 4

(50)

26S proteasome regulatory subunit 6A

(50)

26S proteasome regulatory subunit 6B

(50)

26S proteasome regulatory subunit 7

(50)

26S proteasome regulatory subunit 8

(50)

26S proteasome non-ATPase regulatory subunit 1

(49)

26S proteasome non-ATPase regulatory subunit 11

(49)

26S proteasome non-ATPase regulatory subunit 12

(49)

26S proteasome non-ATPase regulatory subunit 13

(49)

26S proteasome non-ATPase regulatory subunit 14

(49)

26S proteasome non-ATPase regulatory subunit 3

(49)

26S proteasome non-ATPase regulatory subunit 4

(49)

26S proteasome non-ATPase regulatory subunit 6

(49)

26S proteasome non-ATPase regulatory subunit 7

(49)

26S proteasome non-ATPase regulatory subunit 8

(49)

26S proteasome non-ATPase regulatory subunit 2

(48)

26S proteasome complex subunit SEM1

(45)

26S proteasome regulatory subunit 10B

(36)

Ubiquitin

(18)

AAA+ ATPase domain-containing protein

(14)

Ubiquitin carboxyl-terminal hydrolase 14

(14)

Probable proteasome subunit alpha type-7

(9)

Proteasome assembly chaperone 1

(7)

Proteasome assembly chaperone 2

(7)

Substrate

(7)

Proteasome maturation protein

(6)

substrate

(5)

Proteasome activator complex subunit 4

(4)

Proteasome activator complex subunit 1

(3)

Proteasome activator complex subunit 2

(3)

Sem1

(3)

bound Oprozomib

(3)

Thioredoxin-like protein 1

(2)

AN1-type zinc finger protein 5

(1)

ARG-SER-TYR-TYR-SER

(1)

Akirin-2

(1)

EPOXOMICIN (peptide inhibitor)

(1)

Green to red photoconvertible GFP-like protein EosFP

(1)

NEDD8 ultimate buster 1

(1)

Proteasome activator PA28 C-terminal domain-containing protein

(1)

Substrate polypeptide

(1)

Ubiquitin D

(1)

Z-LLY-ketoaldehyde peptide

(1)

sem1

(1)

substrate peptide

(1)

Interacting ligands  (23)

MG : MAGNESIUM ION

(20)

CL : CHLORIDE ION

(9)

1PE : PENTAETHYLENE GLYCOL

(8)

MES : 2-(N-MORPHOLINO)-ETHANESULFONIC ACID

(7)

04C : 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol

(3)

LDZ : N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-L-leucinamide

(3)

3BV : N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide

(2)

BO2 : N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE

(2)

39V : N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-N-[(2S,4R)-5-hydroxy-4-methyl-3-oxo-1-phenylpentan-2-yl]-L-tryptophanamide

(1)

6N5 : ~{N}-[(2~{S})-1-[[(2~{S})-3-(4-methoxyphenyl)-1-[[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-methyl-5~{H}-indene-2-carboxamide

(1)

6NV : ~{N}-[(2~{R})-1-[[(2~{S})-3-(4-methoxyphenyl)-1-[[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-methyl-5~{H}-indene-2-carboxamide

(1)

6V7 : [(1~{R})-3-methyl-1-[[(2~{S},3~{S})-3-oxidanyl-2-[(6-phenylpyridin-2-yl)carbonylamino]butanoyl]amino]butyl]boronic acid

(1)

6V8 : [(1~{R})-1-[2-[[2,5-bis(chloranyl)phenyl]carbonylamino]ethanoylamino]-3-methyl-butyl]boronic acid

(1)

6VC : ~{N}-[(2~{S})-1-[[(2~{S},3~{R},4~{S})-2,6-dimethyl-1,2,3-tris(oxidanyl)heptan-4-yl]amino]-3-oxidanyl-1-oxidanylidene-propan-2-yl]-6-methyl-heptanamide

(1)

79P : (2~{S})-3-(1~{H}-indol-3-yl)-~{N}-[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]-2-[[(2~{R})-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]propanamide

(1)

A1L0C : [(1R)-1-[(1-cyclohexyl-1,2,3-triazol-4-yl)carbonylamino]-3-methyl-butyl]boronic acid

(1)

A1L0D : [(~{R})-cyclohexyl-[(1-cyclohexyl-1,2,3-triazol-4-yl)carbonylamino]methyl]boronic acid

(1)

ACT : ACETATE ION

(1)

KNM : ADA-(AHX)3-(LEU)3-VINYL SULFONE

(1)

SA1 : (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE

(1)

THR : THREONINE

(1)

YHD : N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide

(1)

YRE : (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide

(1)

EC number / name  (1)

3.4.25.1 : Proteasome endopeptidase complex

(105)

Biological function  (5)

threonine-type endopeptidase activity

(104)

endopeptidase activity

(57)

hydrolase activity

(57)

peptidase activity

(57)

protein binding

(57)

Biological process  (5)

proteolysis involved in protein catabolic process

(101)

proteasome assembly

(57)

proteasome-mediated ubiquitin-dependent protein catabolic process

(57)

proteolysis

(57)

response to oxidative stress

(57)

Biological cell component  (9)

proteasome core complex

(104)

centrosome

(57)

cytoplasm

(57)

cytosol

(57)

extracellular exosome

(57)

nucleoplasm

(57)

nucleus

(57)

proteasome complex

(57)

proteasome core complex, beta-subunit complex

(57)

CATH class  (1)

Alpha Beta

(26)

CATH topology  (1)

Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1

(26)

Pfam accession / name  (1)

PF00227 : Proteasome

(105)

Diffraction protocol  (1)

Single wavelength

(24)

Diffraction radiation source type  (1)

Synchrotron

(24)

Diffraction source  (3)

PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)

(11)

SLS BEAMLINE X06SA

(11)

APS BEAMLINE 19-ID

(2)

Synchrotron site  (3)

PETRA III, EMBL c/o DESY

(11)

SLS

(11)

APS

(2)

Diffraction detector type  (2)

Pixel

(22)

CCD

(2)

Refinement software  (3)

PHENIX

(40)

REFMAC

(23)

phenix.real_space_refine

(8)

EM microscope model  (7)

FEI TITAN KRIOS

(54)

FEI TECNAI ARCTICA

(12)

FEI POLARA 300

(5)

TFS KRIOS

(4)

FEI TECNAI 12

(3)

TFS GLACIOS

(2)

FEI TALOS ARCTICA

(1)

EM detector name  (7)

GATAN K2 SUMMIT (4k x 4k)

(47)

GATAN K3 (6k x 4k)

(11)

GATAN K2 QUANTUM (4k x 4k)

(9)

GATAN K3 BIOQUANTUM (6k x 4k)

(6)

FEI FALCON II (4k x 4k)

(5)

FEI FALCON III (4k x 4k)

(2)

OTHER

(1)

Representative Structures

100%

95%

90%

70%

50%

40%

30%