Uniprot accession / id : O88569  OR   Uniprot accession / id : P22626
 
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Entry Information
Entry status  (1)
REL
(13)
 
Experimental methods  (3)
X-ray diffraction
(8)
Electron Microscopy
(4)
Solution NMR
(1)
 
Authors  (40)
Boyer DR
(5)
Cao Q
(5)
Cascio D
(5)
Eisenberg DS
(5)
Hughes MP
(5)
Jaffrey SR
(5)
Lu J
(5)
Ma JB
(5)
Patil DP
(5)
Sawaya MR
(5)
Su SC
(5)
Wu BX
(5)
Gan J
(4)
Liu H
(4)
Ma J
(4)
Su S
(4)
Wu B
(4)
Abskharon R
(3)
Ge P
(3)
Tayeb-Fligelman E
(3)
Abula A
(2)
Chen B
(2)
Gan JH
(2)
Guo H
(2)
Ji X
(2)
Li T
(2)
Liu Y
(2)
Nguyen HC
(2)
Xiao H
(2)
Zheng L
(2)
He F
(1)
Inoue M
(1)
Kigawa T
(1)
Liu HH
(1)
Muto Y
(1)
Nguyen H
(1)
RIKEN Structural Genomics/Proteomics Initiative (RSGI)
(1)
Shirouzu M
(1)
Terada T
(1)
Yokoyama S
(1)
 
Homo / hetero assembly  (2)
hetero
(7)
homo
(6)
 
Assembly composition  (3)
protein structure
(6)
RNA/protein complex
(5)
DNA/protein complex
(2)
 
Assembly polymer count  (6)
dimer
(5)
decamer
(3)
tetramer
(2)
monomer
(1)
pentadecamer
(1)
pentamer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(2)
2.0 - 2.5
(3)
2.5 - 3
(2)
3.0 - 3.5
(3)
3.5 - 4
(1)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(1)
2015 - 2020
(7)
2020 - 2025
(7)
 
Journal  (4)
Nat Commun
(7)
J Biol Chem
(3)
J Mol Biol
(2)
To be published
(1)
 
Macromolecules
Organism superkingdom  (2)
Eukaryota
(13)
Bacteria
(1)
 
Organism name  (2)
Homo sapiens
(13)
Anaplasma marginale
(1)
 
Molecule name  (3)
Heterogeneous nuclear ribonucleoproteins A2/B1
(13)
hnRNP A2/B1
(13)
MCherry fluorescent protein
(1)
 
Molecule type  (1)
Protein
(13)
 
Gene names  (3)
HNRNPA2B1
(13)
HNRPA2B1
(13)
mCherry
(1)
 
Interacting Molecules  (7)
DNA (5'-D(P*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*T)-3')
(1)
DNA (5'-D(P*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3')
(1)
RNA
(1)
RNA (5'-R(*AP*AP*GP*GP*AP*CP*UP*AP*GP*C)-3')
(1)
RNA (5'-R(*AP*AP*GP*GP*AP*CP*UP*U)-3')
(1)
RNA (5'-R(*AP*GP*GP*AP*CP*UP*G)-3')
(1)
RNA (5'-R(*AP*GP*GP*GP*AP*CP*UP*AP*GP*A)-3')
(1)
 
Function and Biology
Biological function  (2)
RNA binding
(8)
nucleic acid binding
(8)
 
Biological process  (1)
bioluminescence
(1)
 
Sequence and Structure classification
SCOP fold  (1)
Ferredoxin-like
(1)
 
SCOP family  (1)
Canonical RBD
(1)
 
CATH class  (1)
Alpha Beta
(6)
 
CATH topology  (1)
Alpha-Beta Plaits
(6)
 
Pfam accession / name  (3)
PF00076 : RRM_1
(8)
PF11627 : HnRNPA1_LC
(4)
PF01353 : GFP
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(8)
 
Diffraction radiation source type  (1)
Synchrotron
(8)
 
Diffraction source  (4)
SSRF BEAMLINE BL18U1
(5)
APS BEAMLINE 24-ID-E
(1)
SSRF BEAMLINE BL17U
(1)
SSRF BEAMLINE BL17U1
(1)
 
Synchrotron site  (2)
SSRF
(7)
APS
(1)
 
Diffraction detector type  (2)
CCD
(4)
Pixel
(4)
 
Refinement software  (2)
REFMAC
(6)
PHENIX
(3)
 
EM microscope model  (1)
FEI TITAN KRIOS
(4)
 
EM detector name  (2)
GATAN K2 SUMMIT (4k x 4k)
(3)
GATAN K2 IS (4k x 4k)
(1)
 
NMR
NMR software packages  (5)
CYANA
(1)
KUJIRA
(1)
NMRPipe
(1)
NMRView
(1)
XwinNMR
(1)
 
NMR Field Strength
700.0 - 800
(1)
800.0 - 900
(1)
 
Representative Structures
Representative Structures
100%
95%
90%
70%
50%
40%
30%
Entries 1 to 10 of 13
Entries 1 to 10 of 13
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hnRNP A2/B1 RRMs in complex with telomeric DNA
Liu Y, Abula A, Xiao H, Guo H, Li T, Zheng L, Chen B, Nguyen H, Ji X
J Mol Biol (2022) [PMID: 36528084  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: Heterogeneous nuclear ribonucleoproteins A2/B1 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-270498 (Preferred)   search this ID
PDBe-KB: P22626   
X-ray diffraction
2.644Å resolution
Released: 29 Nov 2023
Model geometry
Fit model/data
8hni
8hni
8hni
Crystal structure of hnRNPA2B1 in complex with AAGGACUUGC
Wu BX, Su SC, Ma JB
Nat Commun (2018) [PMID: 29379020  ]
Assembly composition: RNA/protein complex
Assembly name: Heterogeneous nuclear ribonucleoproteins A2/B1 and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149687 (Preferred)   search this ID
PDBe-KB: P22626   
X-ray diffraction
2.03Å resolution
Released: 17 Jan 2018
Model geometry
Fit model/data
5wwg
5wwg
5wwg
Crystal structure of hnRNPA2B1 in complex with RNA
Wu BX, Su SC, Ma JB
Nat Commun (2018) [PMID: 29379020  ]
Assembly composition: RNA/protein complex
Assembly name: Heterogeneous nuclear ribonucleoproteins A2/B1 and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149686 (Preferred)   search this ID
PDBe-KB: P22626   
X-ray diffraction
2.15Å resolution
Released: 17 Jan 2018
Model geometry
Fit model/data
5wwf
5wwf
5wwf
Crystal structure of hnRNPA2B1 in complex with RNA
Wu BX, Su SC, Ma JB
Nat Commun (2018) [PMID: 29379020  ]
Assembly composition: RNA/protein complex
Assembly name: Heterogeneous nuclear ribonucleoproteins A2/B1 and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149685 (Preferred)   search this ID
PDBe-KB: P22626   
X-ray diffraction
2.4Å resolution
Released: 17 Jan 2018
Model geometry
Fit model/data
5wwe
5wwe
5wwe
Crystal structure of hnRNPA2B1 in complex with 10-mer RNA
Wu BX, Su SC, Gan JH, Ma JB
Nat Commun (2018) [PMID: 29379020  ]
Assembly composition: RNA/protein complex
Assembly name: Heterogeneous nuclear ribonucleoproteins A2/B1 and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149684 (Preferred)   search this ID
PDBe-KB: P22626   
X-ray diffraction
1.85Å resolution
Released: 8 Feb 2017
Model geometry
Fit model/data
5ho4
5ho4
5ho4
Crystal structure of hnRNPA2B1 in complex with RNA
Wu BX, Su SC, Ma JB
Nat Commun (2018)
Source organism: Homo sapiens  
Assembly composition: RNA/protein complex
Assembly name: Heterogeneous nuclear ribonucleoproteins A2/B1 and RNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149683 (Preferred)   search this ID
PDBe-KB: P22626   
X-ray diffraction
2.58Å resolution
Released: 9 Nov 2016
Model geometry
Fit model/data
5en1
5en1
5en1
hnRNP A2/B1 RRMs in complex with single-stranded DNA
Abula A, Liu Y, Guo H, Li T, Ji X
J Mol Biol (2022) [PMID: 36528084  ]
Source organism: Homo sapiens  
Assembly composition: DNA/protein complex
Assembly name: Heterogeneous nuclear ribonucleoproteins A2/B1 and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-122262 (Preferred)   search this ID
PDBe-KB: P22626   
X-ray diffraction
1.62Å resolution
Released: 29 Jun 2022
Model geometry
Fit model/data
7wm3
7wm3
7wm3
HnRNPA2 D290V LCD PM1
Eisenberg DS, Lu J, Ge P, Boyer DR
J Biol Chem (2023) [PMID: 38072051  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Heterogeneous nuclear ribonucleoproteins A2/B1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149688 (Preferred)   search this ID
PDBe-KB: P22626   
Electron Microscopy
3.3Å resolution
Released: 2 Aug 2023
Model geometry
Fit model/data
Data not analysed
8du2
8du2
8du2
HnRNPA2 D290V LCD PM3
Eisenberg DS, Lu J, Ge P, Boyer DR
J Biol Chem (2023) [PMID: 38072051  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Heterogeneous nuclear ribonucleoproteins A2/B1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-273384 (Preferred)   search this ID
PDBe-KB: P22626   
Electron Microscopy
3.9Å resolution
Released: 6 Sep 2023
Model geometry
Fit model/data
Data not analysed
8ec7
8ec7
8ec7
HnRNPA2 D290V LCD PM2
Eisenberg DS, Lu J, Ge P, Boyer DR
J Biol Chem (2023) [PMID: 38072051  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Heterogeneous nuclear ribonucleoproteins A2/B1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149688 (Preferred)   search this ID
PDBe-KB: P22626   
Electron Microscopy
3.2Å resolution
Released: 2 Aug 2023
Model geometry
Fit model/data
Data not analysed
8duw
8duw
8duw
Entries 1 to 10 of 13
Entries 1 to 10 of 13