Uniprot accession / id : O88634  OR   Uniprot accession / id : Q96RI0
 
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Entry Information
Entry status  (1)
REL
(3)
 
Experimental methods  (1)
X-ray diffraction
(3)
 
Authors  (19)
Chen Z
(2)
Di Cera E
(2)
Appelbaum E
(1)
Bah A
(1)
Beppu A
(1)
Bush-Pelc LA
(1)
Gandhi P
(1)
Gandhi PS
(1)
Hattori M
(1)
Mathews FS
(1)
Nagae M
(1)
Nogi T
(1)
Sanagawa T
(1)
Sangawa T
(1)
Tabata S
(1)
Takagi J
(1)
Tamura-Kawakami K
(1)
Yasui N
(1)
Zapata F
(1)
 
Homo / hetero assembly  (1)
hetero
(3)
 
Assembly composition  (1)
protein/protein complex
(3)
 
Assembly polymer count  (1)
trimer
(3)
 
Resolution distribution
1.5 - 2
(1)
2.5 - 3
(1)
3.0 - 3.5
(1)
 
Release year distribution
2005 - 2010
(2)
2010 - 2015
(1)
 
Journal  (3)
IUBMB Life
(1)
Proc Natl Acad Sci U S A
(1)
Protein Sci
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(3)
 
Organism name  (2)
Homo sapiens
(2)
Mus musculus
(1)
 
Molecule name  (4)
Coagulation factor II receptor-like 3
(3)
PAR-4
(3)
Proteinase-activated receptor 4
(3)
Thrombin receptor-like 3
(3)
 
Molecule type  (1)
Protein
(3)
 
Gene names  (4)
F2RL3
(2)
PAR4
(2)
F2rl3
(1)
Par4
(1)
 
Interacting Molecules  (4)
Thrombin heavy chain
(2)
Thrombin light chain
(2)
IgG1-lambda P20.1 Fab (heavy chain)
(1)
IgG1-lambda P20.1 Fab (light chain)
(1)
 
Function and Biology
Biological function  (1)
thrombin-activated receptor activity
(1)
 
Biological process  (2)
blood coagulation
(1)
thrombin-activated receptor signaling pathway
(1)
 
Biological cell component  (1)
membrane
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(3)
 
Diffraction radiation source type  (2)
Synchrotron
(2)
Rotating anode
(1)
 
Diffraction source  (3)
APS BEAMLINE 14-BM-C
(1)
RIGAKU RU200
(1)
SPRING-8 BEAMLINE BL44XU
(1)
 
Synchrotron site  (2)
APS
(1)
SPring-8
(1)
 
Diffraction detector type  (2)
Image plate
(2)
CCD
(1)
 
Refinement software  (2)
CNS
(2)
REFMAC
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 3 of 3
Entries 1 to 3 of 3
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Crystal structure of the human thrombin mutant D102N in complex with the extracellular fragment of human PAR4.
Gandhi P, Chen Z, Appelbaum E, Zapata F, Di Cera E
IUBMB Life (2011)
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: alpha-thrombin complex and Proteinase-activated receptor 4 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133132 (Preferred)   search this ID
PDBe-KB: Q96RI0    P00734   
X-ray diffraction
2.8Å resolution
Released: 29 Jun 2011
Model geometry
Fit model/data
3qdz
3qdz
3qdz
Crystal structure of P20.1 Fab fragment in complex with its antigen peptide
Nogi T, Sanagawa T, Takagi J
Protein Sci (2008) [PMID: 18787202  ]
Assembly composition: protein/protein complex
Bound ligands: GOL   
Modified residues: PCA    PCA   
Assembly name: Proteinase-activated receptor 4 and IG-light lambda chain and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-234835 (Preferred)   search this ID
PDBe-KB: Q96RI0   
X-ray diffraction
1.8Å resolution
Released: 23 Dec 2008
Model geometry
Fit model/data
2zpk
2zpk
2zpk
Crystal structure of murine thrombin in complex with the extracellular fragment of murine PAR4
Bah A, Chen Z, Bush-Pelc LA, Mathews FS, Di Cera E
Proc Natl Acad Sci U S A (2007) [PMID: 17606903  ]
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Assembly name: Proteinase-activated receptor 4 and Thrombin heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-131569 (Preferred)   search this ID
PDBe-KB: O88634    P19221   
X-ray diffraction
3.5Å resolution
Released: 10 Jul 2007
Model geometry
Fit model/data
2pv9
2pv9
2pv9
Entries 1 to 3 of 3
Entries 1 to 3 of 3