Uniprot accession / id : O88721  OR   Uniprot accession / id : P30518
 
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Entry Information
Entry status  (1)
REL
(22)
 
Experimental methods  (2)
Electron Microscopy
(17)
X-ray diffraction
(5)
 
Authors  (167)
Lefkowitz RJ
(6)
Bous J
(4)
Bron P
(4)
Gao FY
(4)
Granier S
(4)
He QT
(4)
Huang SM
(4)
Jia YL
(4)
Jin C
(4)
Lai-Kee-Him J
(4)
Lin JY
(4)
Mouillac B
(4)
Niu XG
(4)
Orcel H
(4)
Saint-Paul J
(4)
Sounier R
(4)
Sun JP
(4)
Tao XN
(4)
Trapani S
(4)
Wang J
(4)
Xiao KH
(4)
Xiao P
(4)
Yang F
(4)
Yu X
(4)
Zhang X
(4)
Zhao RJ
(4)
Zhu ZL
(4)
des Georges A
(4)
Abzalimov RR
(3)
Bansia H
(3)
Bassford DK
(3)
Kahsai AW
(3)
Kim J
(3)
Li L
(3)
Liu S
(3)
Pakharukova N
(3)
Pani B
(3)
Shukla AK
(3)
Thomas BN
(3)
Zhang C
(3)
Ancelin A
(2)
Banerjee R
(2)
Cai H
(2)
Chami M
(2)
Chen K
(2)
Chu X
(2)
Cong X
(2)
Demene H
(2)
Déméné H
(2)
Floquet N
(2)
Fontanel S
(2)
Fouillen A
(2)
Gaibelet G
(2)
Han S
(2)
Huang LY
(2)
Leyrat C
(2)
Lin S
(2)
Liu Y
(2)
Louet M
(2)
Ma L
(2)
Maharana J
(2)
Saha S
(2)
Sarma P
(2)
Sibille N
(2)
Singh V
(2)
Staus DP
(2)
Urbach S
(2)
Wu B
(2)
Yadav MK
(2)
Yan X
(2)
Yi C
(2)
Zhao Q
(2)
Zhu Y
(2)
Ben-Hail D
(1)
Cahill 3rd TJ
(1)
Cahill TJ
(1)
Cai C
(1)
Cao S
(1)
Capel WD
(1)
Chen N
(1)
Chen X
(1)
Clarke OB
(1)
Croll TI
(1)
Dandey VP
(1)
Ding Y
(1)
Dong Y
(1)
Du Y
(1)
Fan Z
(1)
Gao S
(1)
Guo J
(1)
He X
(1)
Heissel S
(1)
Hilger D
(1)
Hong C
(1)
Hu H
(1)
Hua T
(1)
Huang LH
(1)
Huang R
(1)
Jiang L
(1)
Jiang Y
(1)
 
More...
 
Homo / hetero assembly  (1)
hetero
(22)
 
Assembly composition  (1)
protein/protein complex
(22)
 
Assembly polymer count  (6)
tetramer
(9)
hexamer
(5)
pentamer
(3)
dodecamer
(2)
heptamer
(2)
trimer
(1)
 
Resolution distribution
2.0 - 2.5
(1)
2.5 - 3
(4)
3.0 - 3.5
(8)
3.5 - 4
(4)
4.0 - 4.5
(4)
4.5 - 5
(1)
 
Release year distribution
2010 - 2015
(1)
2015 - 2020
(2)
2020 - 2025
(20)
 
Journal  (9)
Nat Commun
(4)
Nature
(4)
Sci Adv
(4)
bioRxiv
(3)
Cell Res
(2)
Mol Cell
(2)
Cell
(1)
Nat Struct Mol Biol
(1)
Protein Cell
(1)
 
Macromolecules
Organism superkingdom  (2)
Eukaryota
(17)
Viruses
(2)
 
Organism name  (3)
Homo sapiens
(17)
synthetic construct
(4)
Influenza A virus (A/Victoria/3/1975(H3N2))
(2)
 
Molecule name  (22)
AVPR V2
(22)
Antidiuretic hormone receptor
(22)
Renal-type arginine vasopressin receptor
(22)
V2R
(22)
Vasopressin V2 receptor
(22)
Activation peptide
(2)
Anticoagulant protein C
(2)
Autoprothrombin IIA
(2)
Blood coagulation factor XIV
(2)
GL-R
(2)
Glucagon receptor
(2)
Hemagglutinin
(2)
Hemagglutinin HA1 chain
(2)
Hemagglutinin HA2 chain
(2)
Vitamin K-dependent protein C
(2)
Vitamin K-dependent protein C heavy chain
(2)
Vitamin K-dependent protein C light chain
(2)
CANN6
(1)
CB-R
(1)
CB1
(1)
Cannabinoid receptor 1
(1)
Muscarinic acetylcholine receptor M2
(1)
 
Molecule type  (1)
Protein
(22)
 
Gene names  (11)
ADHR
(22)
AVPR2
(22)
DIR
(22)
DIR3
(22)
V2R
(22)
GCGR
(2)
HA
(2)
PROC
(2)
CHRM2
(1)
CNR
(1)
CNR1
(1)
 
Interacting Molecules  (28)
Beta-arrestin-1
(16)
Arg-vasopressin
(5)
Nanobody 32
(5)
FAB30 HEAVY CHAIN
(4)
FAB30 LIGHT CHAIN
(4)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(4)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
(4)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
(4)
Antibody fragment Fab30, heavy chain
(3)
Antibody fragment Fab30, light chain
(3)
Fab30 Heavy Chain
(3)
Fab30 Light Chain
(3)
Nanobody 35
(3)
Proto-oncogene tyrosine-protein kinase Src
(3)
Beta-arrestin-2
(2)
Fab30 heavy chain
(2)
Fab30 light chain
(2)
ScFv30
(2)
Cannabinoid receptor 1
(1)
Glucagon
(1)
Guanine nucleotide-binding protein G(i) subunit alpha-1
(1)
Guanine nucleotide-binding protein G(i) subunit alpha-3
(1)
Ig-like domain-containing protein
(1)
Nanobody35
(1)
Single Fab chain (scFv16)
(1)
Soluble cytochrome b562
(1)
scFv16
(1)
scfv30 light chain, scfv30 heavy chain
(1)
 
Interacting ligands  (4)
PIO : [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
(2)
2CU : 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide
(1)
CLR : CHOLESTEROL
(1)
KCA : methyl N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate
(1)
 
Function and Biology
EC number / name  (1)
3.4.21.69 : Protein C (activated)
(2)
 
Biological function  (14)
G protein-coupled receptor activity
(9)
signaling receptor activity
(7)
protein binding
(5)
vasopressin receptor activity
(5)
glucagon receptor activity
(2)
guanyl-nucleotide exchange factor activity
(2)
peptide hormone binding
(2)
transmembrane signaling receptor activity
(2)
G protein-coupled acetylcholine receptor activity
(1)
arrestin family protein binding
(1)
cannabinoid receptor activity
(1)
electron transfer activity
(1)
heme binding
(1)
iron ion binding
(1)
 
Biological process  (40)
G protein-coupled receptor signaling pathway
(9)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
(8)
signal transduction
(8)
positive regulation of gene expression
(7)
activation of adenylate cyclase activity
(5)
cellular response to hormone stimulus
(5)
hemostasis
(5)
negative regulation of cell population proliferation
(5)
negative regulation of urine volume
(5)
positive regulation of blood pressure
(5)
positive regulation of cell population proliferation
(5)
positive regulation of intracellular signal transduction
(5)
positive regulation of systemic arterial blood pressure
(5)
positive regulation of vasoconstriction
(5)
regulation of systemic arterial blood pressure by vasopressin
(5)
renal water retention
(5)
response to cytokine
(5)
telencephalon development
(5)
adenylate cyclase-activating G protein-coupled receptor signaling pathway
(2)
cell surface receptor signaling pathway
(2)
cellular response to glucagon stimulus
(2)
cellular response to starvation
(2)
generation of precursor metabolites and energy
(2)
glucose homeostasis
(2)
regulation of blood pressure
(2)
regulation of glycogen metabolic process
(2)
response to nutrient
(2)
response to starvation
(2)
G protein-coupled acetylcholine receptor signaling pathway
(1)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(1)
acetylcholine receptor signaling pathway
(1)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
(1)
chemical synaptic transmission
(1)
electron transport chain
(1)
nervous system development
(1)
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
(1)
presynaptic modulation of chemical synaptic transmission
(1)
regulation of heart contraction
(1)
regulation of smooth muscle contraction
(1)
response to virus
(1)
 
Biological cell component  (17)
membrane
(9)
plasma membrane
(8)
Golgi apparatus
(6)
clathrin-coated endocytic vesicle membrane
(6)
endocytic vesicle
(5)
endoplasmic reticulum
(5)
endosome
(5)
perinuclear region of cytoplasm
(5)
cholinergic synapse
(1)
ciliary basal body
(1)
cilium
(1)
dendrite
(1)
nucleolus
(1)
periplasmic space
(1)
postsynaptic membrane
(1)
presynapse
(1)
synapse
(1)
 
Sequence and Structure classification
Pfam accession / name  (3)
PF00001 : 7tm_1
(7)
PF00002 : 7tm_2
(2)
PF02793 : HRM
(2)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(5)
 
Diffraction radiation source type  (1)
Synchrotron
(5)
 
Diffraction source  (4)
SSRF BEAMLINE BL18U1
(2)
APS BEAMLINE 23-ID-D
(1)
SSRF BEAMLINE BL17B1
(1)
SSRF BEAMLINE BL17U1
(1)
 
Synchrotron site  (2)
SSRF
(4)
APS
(1)
 
Diffraction detector type  (2)
Pixel
(3)
CCD
(2)
 
Refinement software  (2)
PHENIX
(14)
phenix.real_space_refine
(2)
 
EM microscope model  (2)
FEI TITAN KRIOS
(15)
TFS KRIOS
(2)
 
EM detector name  (6)
GATAN K3 BIOQUANTUM (6k x 4k)
(5)
GATAN K2 SUMMIT (4k x 4k)
(4)
GATAN K3 (6k x 4k)
(4)
GATAN K2 QUANTUM (4k x 4k)
(2)
FEI FALCON IV (4k x 4k)
(1)
OTHER
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 22
Entries 1 to 10 of 22
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Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Vasopressin V2 receptor, V2R (Local refine)
Maharana J, Sarma P, Yadav MK, Banerjee R, Shukla AK
Mol Cell (2023) [PMID: 37209686  ]
Assembly composition: protein/protein complex
Modified residues: SEP    TPO    SEP    TPO   
PDBe complex ID: PDB-CPX-273520 (Preferred)   search this ID
PDBe-KB: P30518    P32120   
Electron Microscopy
3.96Å resolution
Released: 17 May 2023
Model geometry
Fit model/data
Data not analysed
8i10
8i10
8i10
AVP-V2R-Galphas-beta1-gamma2-Nb35(T state)
Bous J, Mouillac B, Bron P, Granier S, Floquet N, Leyrat C
Sci Adv (2021) [PMID: 34020960  ]
Source organisms: Lama glama  , Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: NH2    NH2   
PDBe complex ID: PDB-CPX-208361 (Preferred)   search this ID
PDBe-KB: P30518    P30518    P62873    P63092    P59768    P01185   
Electron Microscopy
4.4Å resolution
Released: 2 Jun 2021
Model geometry
Fit model/data
Data not analysed
7bb7
7bb7
7bb7
AVP-V2R-Galphas-beta1-gamma2-Nb35 (L state)
Bous J, Mouillac B, Bron P, Granier S, Floquet N, Leyrat C
Sci Adv (2021) [PMID: 34020960  ]
Source organisms: Lama glama  , Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: NH2    NH2   
PDBe complex ID: PDB-CPX-208360 (Preferred)   search this ID
PDBe-KB: P30518    P30518    P62873    P63092    P59768    P01185   
Electron Microscopy
4.2Å resolution
Released: 2 Jun 2021
Model geometry
Fit model/data
Data not analysed
7bb6
7bb6
7bb6
Crystal of Arrestin2-V2Rpp-6-7-Fab30 complex
Sun JP, Yu X, Xiao P, He QT, Lin JY, Zhu ZL
Nat Commun (2021) [PMID: 33888704  ]
Assembly composition: protein/protein complex
Modified residues: SEP    TPO    SEP    TPO   
PDBe complex ID: PDB-CPX-210716 (Preferred)   search this ID
PDBe-KB: P30518    P17870   
X-ray diffraction
3.28Å resolution
Released: 28 Jul 2021
Model geometry
Fit model/data
7dfb
7dfb
7dfb
Crystal of Arrestin2-V2Rpp-4-Fab30 complex
Sun JP, Yu X, Xiao P, He QT, Lin JY, Zhu ZL
Nat Commun (2021) [PMID: 33888704  ]
Assembly composition: protein/protein complex
Modified residues: SEP    TPO    SEP    TPO   
PDBe complex ID: PDB-CPX-210715 (Preferred)   search this ID
PDBe-KB: P30518    P17870   
X-ray diffraction
2.54Å resolution
Released: 28 Jul 2021
Model geometry
Fit model/data
7dfa
7dfa
7dfa
Crystal of Arrestin2-V2Rpp-1-Fab30 complex
Sun JP, Yu X, Xiao P, He QT, Lin JY, Zhu ZL
Nat Commun (2021) [PMID: 33888704  ]
Assembly composition: protein/protein complex
Modified residues: SEP    TPO    SEP    TPO   
PDBe complex ID: PDB-CPX-276161 (Preferred)   search this ID
PDBe-KB: P30518    P17870   
X-ray diffraction
3.17Å resolution
Released: 28 Jul 2021
Model geometry
Fit model/data
7df9
7df9
7df9
Cryo-EM structure of human V2 vasopressin receptor in complex with an Gs protein
Zhou F, Jiang Y
Cell Res (2021) [PMID: 33742150  ]
Assembly composition: protein/protein complex
Bound ligands: CLR    CLR   
Modified residues: NH2    NH2   
PDBe complex ID: PDB-CPX-208359 (Preferred)   search this ID
PDBe-KB: P30518    P63092    P54311    P63096    P63212    P01185   
Electron Microscopy
2.6Å resolution
Released: 21 Jul 2021
Model geometry
Fit model/data
Data not analysed
7dw9
7dw9
7dw9
Structure of the V2 receptor Cter-arrestin2-ScFv30 complex
Bous J, Fouillen A, Trapani S, Granier S, Mouillac B, Bron P
Sci Adv (2022) [PMID: 36054364  ]
Assembly composition: protein/protein complex
Modified residues: SEP    TPO    SEP    TPO   
PDBe complex ID: PDB-CPX-279899 (Preferred)   search this ID
PDBe-KB: P30518    P49407   
Electron Microscopy
4.23Å resolution
Released: 14 Sep 2022
Model geometry
Fit model/data
Data not analysed
7r0j
7r0j
7r0j
Cry-EM structure of cannabinoid receptor-beta-arrestin-1 complex
Wang YX, Wang T, Wu LJ, Hua T, Liu ZJ
Protein Cell (2023) [PMID: 38102480  ]
Assembly composition: protein/protein complex
Bound ligands: 8D0   
Modified residues: SEP    TPO    SEP    TPO   
PDBe complex ID: PDB-CPX-272581 (Preferred)   search this ID
PDBe-KB: P30518    P0ABE7    P49407    P21554   
Electron Microscopy
3.6Å resolution
Released: 28 Feb 2024
Model geometry
Fit model/data
Data not analysed
8wrz
8wrz
8wrz
Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state
Chen K, Zhang C, Lin S, Zhao Q, Wu B
Nature (2023) [PMID: 37558880  ]
Assembly composition: protein/protein complex
Bound ligands: PIO    PIO   
Modified residues: SEP    TPO    SEP    TPO   
PDBe complex ID: PDB-CPX-272209 (Preferred)   search this ID
PDBe-KB: P04070    P30518    P47871    P03435    P17870   
Electron Microscopy
3.5Å resolution
Released: 16 Aug 2023
Model geometry
Fit model/data
Data not analysed
8jru
8jru
8jru
Entries 1 to 10 of 22
Entries 1 to 10 of 22