Uniprot accession / id : O89026  OR   Uniprot accession / id : Q9Y6N7
 
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Entry Information
Entry status  (1)
REL
(12)
 
Experimental methods  (2)
X-ray diffraction
(11)
Solution NMR
(1)
 
Authors  (43)
McCarthy AA
(6)
Fujitani H
(4)
Hamakubo T
(4)
Inoue T
(4)
Iwanari H
(4)
Kado Y
(4)
Kodama T
(4)
Mizohata E
(4)
Mochizuki Y
(4)
Nagatoishi S
(4)
Nakakido M
(4)
Nakayama T
(4)
Tsumoto K
(4)
Yamashita T
(4)
Yokota Y
(4)
Aleksandrova N
(3)
Avilov SV
(3)
Cusack S
(3)
Gros P
(3)
Gutsche I
(3)
Hemrika W
(3)
Kandiah E
(3)
Kawamura T
(3)
Matsumura H
(3)
Mccarthy AA
(3)
Morlot C
(3)
Petoukhov MV
(3)
Ravelli RB
(3)
Romijn RA
(3)
Seiradake E
(3)
Thielens NM
(3)
Watanabe T
(3)
Barak R
(1)
Hayashi F
(1)
Nagashima K
(1)
Nagatoishi M
(1)
Opatowsky Y
(1)
RIKEN Structural Genomics/Proteomics Initiative (RSGI)
(1)
Ravelli RBG
(1)
Sato R
(1)
Satoh R
(1)
Yokoyama S
(1)
Yoshida M
(1)
 
Homo / hetero assembly  (2)
homo
(7)
hetero
(5)
 
Assembly composition  (2)
protein structure
(7)
protein/protein complex
(5)
 
Assembly polymer count  (3)
monomer
(7)
trimer
(4)
dimer
(1)
 
Resolution distribution
1.5 - 2
(5)
2.0 - 2.5
(3)
2.5 - 3
(1)
3.0 - 3.5
(2)
 
Release year distribution
2005 - 2010
(4)
2010 - 2015
(2)
2015 - 2020
(7)
 
Journal  (4)
Structure
(6)
Proc Natl Acad Sci U S A
(3)
To be published
(2)
Protein Sci
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(12)
 
Organism name  (1)
Homo sapiens
(12)
 
Molecule name  (3)
Deleted in U twenty twenty
(12)
H-Robo-1
(12)
Roundabout homolog 1
(12)
 
Molecule type  (1)
Protein
(12)
 
Gene names  (2)
DUTT1
(12)
ROBO1
(12)
 
Interacting Molecules  (8)
Light chain region of the anti-human Robo1 antibody B5209B scFv
(2)
Heavy chain and linker region of the anti-human Robo1 antibody B5209B scFv
(1)
Heavy chain of the anti-human Robo1 antibody B5209B Fab
(1)
Heavy chain of the anti-human Robo1 antibody B5209B scFv
(1)
Light chain of the anti-human Robo1 antibody B5209B Fab
(1)
Slit homolog 2 protein N-product
(1)
anti-human ROBO1 antibody B2212A Fab heavy chain
(1)
anti-human ROBO1 antibody B2212A Fab light chain
(1)
 
Interacting ligands  (4)
1PE : PENTAETHYLENE GLYCOL
(1)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(1)
PO4 : PHOSPHATE ION
(1)
SO4 : SULFATE ION
(1)
 
Function and Biology
Biological function  (1)
axon guidance receptor activity
(2)
 
Biological process  (3)
Roundabout signaling pathway
(2)
axon guidance
(2)
axon midline choice point recognition
(2)
 
Sequence and Structure classification
CATH class  (1)
Mainly Beta
(10)
 
CATH topology  (1)
Immunoglobulin-like
(10)
 
Pfam accession / name  (3)
PF13927 : Ig_3
(10)
PF07679 : I-set
(4)
PF00041 : fn3
(2)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(11)
 
Diffraction radiation source type  (1)
Synchrotron
(11)
 
Diffraction source  (5)
ESRF BEAMLINE ID14-4
(5)
SPRING-8 BEAMLINE BL44XU
(3)
ESRF BEAMLINE BM14
(1)
ESRF BEAMLINE ID23-1
(1)
SPRING-8 BEAMLINE BL38B1
(1)
 
Synchrotron site  (2)
ESRF
(7)
SPring-8
(4)
 
Diffraction detector type  (1)
CCD
(11)
 
Refinement software  (3)
REFMAC
(7)
BUSTER
(3)
PHENIX
(2)
 
NMR
NMR software packages  (5)
CYANA
(1)
KUJIRA
(1)
NMRPipe
(1)
NMRView
(1)
VNMR
(1)
 
NMR Field Strength
700.0 - 800
(1)
800.0 - 900
(1)
 
Representative Structures
Representative Structures
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90%
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40%
30%
Entries 1 to 10 of 12
Entries 1 to 10 of 12
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Robo1 Ig1-4 crystals form 2
Aleksandrova N, Gutsche I, Kandiah E, Avilov SV, Petoukhov MV, Seiradake E, McCarthy AA
Structure (2018) [PMID: 29307485  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PO4   
Assembly name: Roundabout homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-195377 (Preferred)   search this ID
PDBe-KB: Q9Y6N7   
X-ray diffraction
2.54Å resolution
Released: 17 Jan 2018
Model geometry
Fit model/data
5ope
5ope
5ope
Robo1 Ig1 to 4 crystal form 1
Aleksandrova N, Gutsche I, Kandiah E, Avilov SV, Petoukhov MV, Seiradake E, McCarthy AA
Structure (2018) [PMID: 29307485  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NAG    NAG   
Assembly name: Roundabout homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-195377 (Preferred)   search this ID
PDBe-KB: Q9Y6N7   
X-ray diffraction
3.03Å resolution
Released: 17 Jan 2018
Model geometry
Fit model/data
5o5g
5o5g
5o5g
Robo1 Ig5
Aleksandrova N, Gutsche I, Kandiah E, Avilov SV, Petoukhov MV, Seiradake E, McCarthy AA
Structure (2018) [PMID: 29307485  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Roundabout homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-195377 (Preferred)   search this ID
PDBe-KB: Q9Y6N7   
X-ray diffraction
3.01Å resolution
Released: 17 Jan 2018
Model geometry
Fit model/data
5o5i
5o5i
5o5i
Crystal structure of the fifth immunoglobulin domain (Ig5) of human Robo1 in complex with the scFv fragment of murine monoclonal antibody B5209B
Mizohata E, Nakayama T, Kado Y, Inoue T
Structure (2019) [PMID: 30595454  ]
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Roundabout homolog 1 and IG-light kappa chain and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-212895 (Preferred)   search this ID
PDBe-KB: Q9Y6N7   
X-ray diffraction
2.1Å resolution
Released: 30 Jan 2019
Model geometry
Fit model/data
6a78
6a78
6a78
Solution structure of the fifth ig-like domain from human Roundabout homo1
Nagashima K, Yoshida M, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Roundabout homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-195377 (Preferred)   search this ID
PDBe-KB: Q9Y6N7   
Solution NMR
Released: 2 Oct 2007
Model geometry
Fit model/data
Data not analysed
2eo9
2eo9
2eo9
Crystal structure of the fifth immunoglobulin domain (Ig5) of human Robo1 in complex with the mutant scFv fragment (P103A) of murine monoclonal antibody B5209B
Mizohata E, Nakayama T, Kado Y, Yokota Y, Inoue T
Structure (2019) [PMID: 30595454  ]
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Roundabout homolog 1 and IG-light kappa chain and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-212896 (Preferred)   search this ID
PDBe-KB: Q9Y6N7   
X-ray diffraction
2.31Å resolution
Released: 30 Jan 2019
Model geometry
Fit model/data
6a79
6a79
6a79
Crystal structure of the fifth immunoglobulin domain (Ig5) of human Robo1 in complex with the Fab fragment of murine monoclonal antibody B5209B
Mizohata E, Nakayama T, Kado Y, Inoue T
Structure (2019) [PMID: 30595454  ]
Assembly composition: protein/protein complex
Assembly name: Roundabout homolog 1 and IG-light kappa chain and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-212894 (Preferred)   search this ID
PDBe-KB: Q9Y6N7   
X-ray diffraction
2Å resolution
Released: 30 Jan 2019
Model geometry
Fit model/data
6a77
6a77
6a77
Crystal structure of the third fibronectin domain (Fn3) of human ROBO1 in complex with the Fab fragment of murine monoclonal antibody B2212A.
Nakayama T, Mizohata E, Yamashita T, Nagatoishi M, Iwanari H, Mochizuki Y, Kado Y, Yokota Y, Sato R, Tsumoto K, Fujitani H, Kodama T, Hamakubo T, Inoue T
Protein Sci (2015) [PMID: 25492858  ]
Assembly composition: protein/protein complex
Bound ligands: GOL   
Assembly name: Roundabout homolog 1 and IG-light kappa chain and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-235417 (Preferred)   search this ID
PDBe-KB: Q9Y6N7   
X-ray diffraction
1.701Å resolution
Released: 21 Jan 2015
Model geometry
Fit model/data
3wih
3wih
3wih
Axon Guidance Receptor
Barak R, Opatowsky Y
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 1PE    1PE   
Assembly name: Roundabout homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-195377 (Preferred)   search this ID
PDBe-KB: Q9Y6N7   
X-ray diffraction
1.8Å resolution
Released: 20 Nov 2013
Model geometry
Fit model/data
4hlj
4hlj
4hlj
First and second Ig domains from human Robo1 (Form 2)
Morlot C, Cusack S, McCarthy AA
Proc Natl Acad Sci U S A (2007) [PMID: 17848514  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SO4   
Assembly name: Roundabout homolog 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-195377 (Preferred)   search this ID
PDBe-KB: Q9Y6N7   
X-ray diffraction
2Å resolution
Released: 25 Sep 2007
Model geometry
Fit model/data
2v9r
2v9r
2v9r
Entries 1 to 10 of 12
Entries 1 to 10 of 12