Entry status  (1)

REL

(10)

Experimental methods  (2)

Solution NMR

(5)

X-ray diffraction

(5)

Authors  (61)

Anglister J

(3)

Akabayov SR

(2)

Garcia KC

(2)

Glenn JS

(2)

Krutzik PO

(2)

Lee C

(2)

Levin D

(2)

Levy R

(2)

Moraga I

(2)

Nolan GP

(2)

Nudelman I

(2)

Piehler J

(2)

Podoplelova Y

(2)

Schreiber G

(2)

Thomas C

(2)

Trejo A

(2)

Vleck SE

(2)

Yarden G

(2)

Aubin Y

(1)

Belcourt PJ

(1)

Belcourt PJF

(1)

Biron Z

(1)

Bosanac I

(1)

Brochu D

(1)

Chill JH

(1)

Corpuz R

(1)

Dall'Acqua WF

(1)

Eigenbrot C

(1)

Ghasriani H

(1)

Gilbert M

(1)

Gingras G

(1)

Gsell B

(1)

Hodgson DJ

(1)

Hruza A

(1)

Kessler N

(1)

Klaus W

(1)

Kwong M

(1)

Labhardt AM

(1)

Maurer B

(1)

Nagabhushan TL

(1)

Oganesyan V

(1)

Peng L

(1)

Quadt-Akabayov SR

(1)

Radhakrishnan R

(1)

Reichert P

(1)

Sauve S

(1)

Sauvé S

(1)

Scherf T

(1)

Schmidt K

(1)

Schnur E

(1)

Senn H

(1)

Shia S

(1)

Trotta PP

(1)

Vandlen R

(1)

Walter LJ

(1)

Walter MR

(1)

Wipf B

(1)

Woods RM

(1)

Wu H

(1)

Xu Y

(1)

Yang D

(1)

Homo / hetero assembly  (2)

hetero

(7)

homo

(3)

Assembly composition  (2)

protein/protein complex

(7)

protein structure

(3)

Assembly polymer count  (3)

dimer

(4)

monomer

(3)

trimer

(3)

Resolution distribution

1.5 - 2

(1)

2.5 - 3

(3)

4.0 - 4.5

(1)

Release year distribution

1995 - 2000

(2)

2005 - 2010

(2)

2010 - 2015

(7)

2015 - 2020

(2)

Journal  (7)

Cell

(2)

J Biol Chem

(2)

Protein Sci

(2)

Biochemistry

(1)

J Am Chem Soc

(1)

J Mol Biol

(1)

Structure

(1)

Organism superkingdom  (1)

Eukaryota

(10)

Organism name  (1)

Homo sapiens

(10)

Molecule name  (20)

IFN-alpha-2

(10)

Interferon alpha-2

(10)

Interferon alpha-A

(10)

LeIF A

(10)

IFN-R-2

(5)

IFN-alpha binding protein

(5)

IFN-alpha/beta receptor 2

(5)

Interferon alpha binding protein

(5)

Interferon alpha/beta receptor 2

(5)

Type I interferon receptor 2

(5)

CRF2-1

(1)

Cytokine receptor class-II member 1

(1)

Cytokine receptor family 2 member 1

(1)

IFN-R-1

(1)

IFN-alpha/beta receptor 1

(1)

IG-light kappa chain

(1)

IGK@ protein

(1)

Ig-like domain-containing protein

(1)

Interferon alpha/beta receptor 1

(1)

Type I interferon receptor 1

(1)

Molecule type  (1)

Protein

(10)

Gene names  (10)

IFNA2

(10)

IFNA2A

(10)

IFNA2B

(10)

IFNA2C

(10)

IFNABR

(5)

IFNAR2

(5)

IFNARB

(5)

IFNAR

(1)

IFNAR1

(1)

IGK@

(1)

Interacting Molecules  (7)

Interferon alpha-2

(6)

Interferon alpha/beta receptor 2

(5)

Ig-like domain-containing protein

(1)

Interferon alpha/beta receptor 1

(1)

Sifalimumab heavy chain

(1)

anti-IFN-a antibody rontalizumab heavy chain modules VH and CH1 (Fab)

(1)

anti-IFN-a antibody rontalizumab light chain

(1)

Interacting ligands  (4)

A2G : 2-acetamido-2-deoxy-alpha-D-galactopyranose

(1)

CL : CHLORIDE ION

(1)

NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose

(1)

NI : NICKEL (II) ION

(1)

Biological function  (4)

cytokine activity

(10)

cytokine receptor binding

(10)

protein binding

(10)

type I interferon receptor binding

(10)

Biological process  (22)

B cell activation involved in immune response

(10)

T cell activation involved in immune response

(10)

adaptive immune response

(10)

apoptotic process

(10)

cell surface receptor signaling pathway

(10)

cell surface receptor signaling pathway via STAT

(10)

cell-cell signaling

(10)

cellular response to virus

(10)

defense response

(10)

defense response to virus

(10)

host-mediated suppression of symbiont invasion

(10)

humoral immune response

(10)

inflammatory response

(10)

natural killer cell activation involved in immune response

(10)

negative regulation of DNA-templated transcription

(10)

negative regulation of T cell differentiation

(10)

negative regulation of T-helper 2 cell cytokine production

(10)

negative regulation of gene expression

(10)

negative regulation of interleukin-13 production

(10)

negative regulation of interleukin-5 production

(10)

response to exogenous dsRNA

(10)

type I interferon-mediated signaling pathway

(10)

Biological cell component  (3)

collagen-containing extracellular matrix

(10)

extracellular region

(10)

extracellular space

(10)

SCOP fold  (2)

4-helical cytokines

(3)

Immunoglobulin-like beta-sandwich

(1)

SCOP family  (2)

Interferons/interleukin-10 (IL-10)

(3)

Fibronectin type III

(1)

CATH class  (2)

Mainly Alpha

(9)

Mainly Beta

(6)

CATH topology  (2)

Growth Hormone; Chain: A;

(9)

Immunoglobulin-like

(6)

Pfam accession / name  (5)

PF00143 : Interferon

(10)

PF01108 : Tissue_fac

(5)

PF09294 : Interfer-bind

(5)

PF07654 : C1-set

(1)

PF07686 : V-set

(1)

Diffraction protocol  (1)

Single wavelength

(5)

Diffraction radiation source type  (2)

Synchrotron

(3)

Rotating anode

(2)

Diffraction source  (5)

ALS BEAMLINE 5.0.2

(1)

ALS BEAMLINE 8.2.1

(1)

ALS BEAMLINE 8.2.2

(1)

RIGAKU MICROMAX-007 HF

(1)

RIGAKU RUH2R

(1)

Synchrotron site  (1)

ALS

(3)

Diffraction detector type  (2)

CCD

(3)

Image plate

(2)

Refinement software  (3)

PHENIX

(2)

REFMAC

(2)

X-PLOR

(2)

NMR software packages  (7)

HADDOCK

(3)

NMRPipe

(2)

NMRView

(2)

XwinNMR

(2)

CYANA

(1)

TopSpin

(1)

X-PLOR

(1)

NMR Field Strength

400.0 - 500

(2)

500.0 - 600

(3)

600.0 - 700

(2)

700.0 - 800

(4)

800.0 - 900

(3)

Representative Structures

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