Entry status  (1)

REL

(10)

Experimental methods  (1)

X-ray diffraction

(10)

Authors  (40)

Augustin M

(4)

Boettcher J

(4)

Bottcher J

(4)

Broughton SE

(4)

Böttcher J

(4)

Dhagat U

(4)

Eylenstein R

(4)

Hartle S

(4)

Hercus TR

(4)

Härtle S

(4)

Lopez AF

(4)

McClure BJ

(4)

Nero TL

(4)

Ostendorp R

(4)

Parker MW

(4)

Steidl S

(4)

Strohner R

(4)

Weinfurtner D

(4)

Barry EF

(2)

Bryson S

(2)

Cheung Tung Shing KS

(2)

Dottore M

(2)

Gorman MA

(2)

King-Scott J

(2)

Pai EF

(2)

Schrader JW

(2)

Taing H

(2)

Thomson CA

(2)

Boone T

(1)

Bugg CE

(1)

Cook WJ

(1)

Diederichs K

(1)

Ealick SE

(1)

Hecht R

(1)

Karplus PA

(1)

Nagabhushan TL

(1)

Rozwarski D

(1)

Rozwarski DA

(1)

Trotta PP

(1)

Walter MR

(1)

Homo / hetero assembly  (2)

hetero

(8)

homo

(2)

Assembly composition  (2)

protein/protein complex

(8)

protein structure

(2)

Assembly polymer count  (3)

trimer

(7)

dimer

(2)

monomer

(1)

Resolution distribution

1.5 - 2

(1)

2.0 - 2.5

(3)

2.5 - 3

(5)

3.0 - 3.5

(1)

Release year distribution

1990 - 1995

(1)

1995 - 2000

(1)

2010 - 2015

(6)

2015 - 2020

(8)

Journal  (4)

MAbs

(6)

Structure

(2)

J Mol Biol

(1)

Proteins

(1)

Organism superkingdom  (1)

Eukaryota

(10)

Organism name  (1)

Homo sapiens

(10)

Molecule name  (14)

CSF

(10)

Colony-stimulating factor

(10)

GM-CSF

(10)

Granulocyte-macrophage colony-stimulating factor

(10)

Molgramostin

(10)

Sargramostim

(10)

CDw116

(2)

GM-CSF-R-alpha

(2)

GMCSFR-alpha

(2)

GMR-alpha

(2)

Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

(2)

CDw131

(1)

Cytokine receptor common subunit beta

(1)

GM-CSF/IL-3/IL-5 receptor common beta subunit

(1)

Molecule type  (1)

Protein

(10)

Gene names  (8)

CSF2

(10)

GMCSF

(10)

CSF2R

(2)

CSF2RA

(2)

CSF2RY

(2)

CSF2RB

(1)

IL3RB

(1)

IL5RB

(1)

Interacting Molecules  (9)

Immunglobulin G1 Fab fragment, heavy chain

(4)

Immunglobulin G1 Fab fragment, light chain

(4)

Granulocyte-macrophage colony-stimulating factor

(2)

Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

(2)

Cytokine receptor common subunit beta

(1)

Fab Heavy Chain

(1)

Fab Heavy chain

(1)

Fab Light Chain

(1)

Fab light Chain

(1)

Interacting ligands  (3)

NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose

(2)

GOL : GLYCEROL

(1)

PGE : TRIETHYLENE GLYCOL

(1)

Biological function  (5)

granulocyte macrophage colony-stimulating factor receptor binding

(10)

growth factor activity

(10)

cytokine activity

(7)

protein binding

(7)

cytokine receptor activity

(2)

Biological process  (30)

immune response

(10)

cell population proliferation

(7)

cell surface receptor signaling pathway via JAK-STAT

(7)

cell surface receptor signaling pathway via STAT

(7)

cellular response to granulocyte macrophage colony-stimulating factor stimulus

(7)

cellular response to lipopolysaccharide

(7)

dendritic cell differentiation

(7)

embryonic placenta development

(7)

epithelial fluid transport

(7)

granulocyte-macrophage colony-stimulating factor signaling pathway

(7)

histamine secretion

(7)

macrophage differentiation

(7)

monocyte differentiation

(7)

myeloid cell differentiation

(7)

myeloid dendritic cell differentiation

(7)

negative regulation of DNA-templated transcription

(7)

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

(7)

neutrophil differentiation

(7)

positive regulation of cell migration

(7)

positive regulation of cell population proliferation

(7)

positive regulation of gene expression

(7)

positive regulation of interleukin-23 production

(7)

positive regulation of leukocyte proliferation

(7)

positive regulation of macrophage derived foam cell differentiation

(7)

positive regulation of podosome assembly

(7)

regulation of cell population proliferation

(7)

regulation of circadian sleep/wake cycle, sleep

(7)

regulation of gene expression

(7)

response to fluid shear stress

(7)

response to silicon dioxide

(7)

Biological cell component  (6)

extracellular region

(10)

extracellular space

(7)

granulocyte macrophage colony-stimulating factor receptor complex

(7)

intracellular membrane-bounded organelle

(7)

plasma membrane

(7)

membrane

(2)

SCOP fold  (1)

4-helical cytokines

(2)

SCOP family  (1)

Short-chain cytokines

(2)

CATH class  (2)

Mainly Alpha

(10)

Mainly Beta

(1)

CATH topology  (2)

Growth Hormone; Chain: A;

(10)

Immunoglobulin-like

(1)

Pfam accession / name  (4)

PF01109 : GM_CSF

(10)

PF09240 : IL6Ra-bind

(2)

PF18611 : IL3Ra_N

(1)

PF21460 : IL3Rb_N

(1)

Diffraction protocol  (1)

Single wavelength

(8)

Diffraction radiation source type  (1)

Synchrotron

(8)

Diffraction source  (4)

AUSTRALIAN SYNCHROTRON BEAMLINE MX2

(3)

SLS BEAMLINE X06SA

(3)

APS BEAMLINE 19-BM

(1)

SLS BEAMLINE X06DA

(1)

Synchrotron site  (3)

SLS

(4)

Australian Synchrotron

(3)

APS

(1)

Diffraction detector type  (2)

CCD

(4)

Pixel

(4)

Representative Structures

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