Uniprot accession / id : P05125  OR   Uniprot accession / id : P01160
 
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Entry Information
Entry status  (1)
REL
(8)
 
Experimental methods  (3)
X-ray diffraction
(5)
Electron Microscopy
(2)
Solution NMR
(1)
 
Authors  (70)
Ogawa H
(3)
Baras A
(1)
Botermans W
(1)
Burczynski ME
(1)
Chalasani N
(1)
Cunningham BC
(1)
De T
(1)
Devalaraja-Narashimha KB
(1)
Dickey DM
(1)
Dukkipati A
(1)
Dunn ME
(1)
Eng ET
(1)
Fairbrother WJ
(1)
Franklin MC
(1)
Funke T
(1)
Garcia KC
(1)
Garnova E
(1)
Guo Q
(1)
He X
(1)
He XL
(1)
Herman G
(1)
Hite RK
(1)
Ho AJ
(1)
Huang T
(1)
Huang X
(1)
Huang XY
(1)
Jasewicz D
(1)
Jin X
(1)
Kamat V
(1)
Karnik S
(1)
Kim JH
(1)
Kithcart A
(1)
Liu N
(1)
Liu S
(1)
Liu W
(1)
Locke A
(1)
Lotta LA
(1)
Mastaitis J
(1)
McDowell RS
(1)
Mcdowell RS
(1)
Melander O
(1)
Meyer J
(1)
Miao Y
(1)
Morton L
(1)
Murphy AJ
(1)
Musser BJ
(1)
Nielsen JB
(1)
Olenchock BA
(1)
Olson W
(1)
Paknejad N
(1)
Pan H
(1)
Pandit A
(1)
Payne AM
(1)
Potter LR
(1)
Rafique A
(1)
Ralat LA
(1)
Rankin AJ
(1)
Ren M
(1)
Romero Hernandez A
(1)
Rosconi M
(1)
Schwantes-An TH
(1)
Tang W-J
(1)
Torello J
(1)
Verweij N
(1)
Wang J
(1)
Yancopoulos GD
(1)
Zhang D
(1)
Zheng W
(1)
Zhu L
(1)
de Hoon J
(1)
 
Homo / hetero assembly  (2)
hetero
(7)
homo
(1)
 
Assembly composition  (2)
protein/protein complex
(7)
protein structure
(1)
 
Assembly polymer count  (4)
trimer
(5)
heptamer
(1)
monomer
(1)
tetramer
(1)
 
Resolution distribution
2.0 - 2.5
(2)
2.5 - 3
(2)
3.0 - 3.5
(3)
 
Release year distribution
1990 - 1995
(1)
1995 - 2000
(1)
2005 - 2010
(2)
2010 - 2015
(1)
2020 - 2025
(5)
 
Journal  (5)
To be published
(4)
Biochemistry
(1)
J Mol Biol
(1)
Nat Struct Mol Biol
(1)
Nature
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(8)
 
Organism name  (1)
Homo sapiens
(8)
 
Molecule name  (63)
ANF
(8)
ANF 1-33
(8)
ANF 3-33
(8)
ANF 8-33
(8)
ANP
(8)
Alpha-atrial natriuretic peptide
(8)
Alpha-hANP
(8)
Atrial natriuretic factor
(8)
Atrial natriuretic factor 1-33
(8)
Atrial natriuretic factor 3-33
(8)
Atrial natriuretic factor 8-33
(8)
Atrial natriuretic factor prohormone
(8)
Atrial natriuretic peptide
(8)
Atrial natriuretic peptide prohormone
(8)
Atriopeptigen
(8)
Atriopeptin I
(8)
Atriopeptin II
(8)
Atriopeptin III
(8)
Atriopeptin-1
(8)
Atriopeptin-2
(8)
Atriopeptin-3
(8)
Auriculin-A
(8)
Auriculin-B
(8)
Auriculin-C
(8)
Auriculin-D
(8)
CDD
(8)
CDD 95-126
(8)
CDD-ANF
(8)
CDD-ANP (95-126)
(8)
CDD-ANP (99-126)
(8)
Cardiodilatin
(8)
Cardionatrin
(8)
KP
(8)
Kaliuretic peptide
(8)
LANH
(8)
LANP
(8)
Long-acting natriuretic hormone
(8)
Long-acting natriuretic peptide
(8)
Natriuretic peptides A
(8)
Pro atrial natriuretic factor 1-30
(8)
Pro atrial natriuretic factor 31-67
(8)
Pro atrial natriuretic factor 79-98
(8)
Pro atrial natriuretic factor 99-126
(8)
Pro atrial natriuretic peptide 1-30
(8)
Pro atrial natriuretic peptide 31-67
(8)
Pro atrial natriuretic peptide 79-98
(8)
Pro atrial natriuretic peptide 95-126
(8)
URO
(8)
Urodilatin
(8)
VSDL
(8)
Vessel dilator
(8)
preproANP
(8)
preproCDD-ANF
(8)
proANF
(8)
proANF 1-30
(8)
proANF 31-67
(8)
proANF 79-98
(8)
proANF 99-126
(8)
proANP
(8)
proANP 1-30
(8)
proANP 31-67
(8)
proANP 79-98
(8)
proANP 95-126
(8)
 
Molecule type  (1)
Protein
(8)
 
Gene names  (3)
ANP
(8)
NPPA
(8)
PND
(8)
 
Interacting Molecules  (5)
Atrial natriuretic peptide receptor 1
(5)
Atrial natriuretic peptide receptor 3
(1)
Insulin-degrading enzyme
(1)
REGN5381 Fab heavy chain
(1)
REGN5381 Fab light chain
(1)
 
Function and Biology
Biological function  (1)
hormone activity
(7)
 
Biological cell component  (1)
extracellular region
(7)
 
Sequence and Structure classification
SCOP fold  (1)
Atrial natriuretic peptide
(1)
 
SCOP family  (1)
Atrial natriuretic peptide
(1)
 
Pfam accession / name  (1)
PF00212 : ANP
(8)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(5)
 
Diffraction radiation source type  (1)
Synchrotron
(5)
 
Diffraction source  (3)
SPRING-8 BEAMLINE BL41XU
(3)
APS BEAMLINE 19-ID
(1)
SSRL BEAMLINE BL11-1
(1)
 
Synchrotron site  (3)
SPring-8
(3)
APS
(1)
SSRL
(1)
 
Diffraction detector type  (1)
CCD
(5)
 
Refinement software  (3)
PHENIX
(3)
CNS
(1)
REFMAC
(1)
 
EM microscope model  (1)
FEI TITAN KRIOS
(2)
 
EM detector name  (2)
GATAN K3 (6k x 4k)
(1)
GATAN K3 BIOQUANTUM (6k x 4k)
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 8 of 8
Entries 1 to 8 of 8
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Atrial Natriuretic Peptide Receptor complexed with human Atrial Natriuretic Peptide
Ogawa H
To be published
Assembly composition: protein/protein complex
Bound ligands: CL   
Carbohydrate polymer components:
Molecule 1 - MAN(1), NAG(2)
Molecule 2 - MAN(2), NAG(2)
Assembly name: ANPR-A receptor complex and Atrial natriuretic peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-134081 (Preferred)   search this ID
PDBe-KB: P01160    P18910   
X-ray diffraction
2.45Å resolution
Released: 31 Mar 2021
Model geometry
Fit model/data
7brh
7brh
7brh
Extracellular domain of GC-A bound to ANP
Liu S, Huang X
Nat Struct Mol Biol (2024) [PMID: 39543315  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NAG    CL    NAG   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Molecule 2 - MAN(1), NAG(2)
Assembly name: ANPR-A receptor complex and Atrial natriuretic peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-281436 (Preferred)   search this ID
PDBe-KB: P01160    P16066   
Electron Microscopy
3.1Å resolution
Released: 27 Nov 2024
Model geometry
Fit model/data
Data not analysed
9bcq
9bcq
9bcq
Atrial Natriuretic Peptide Receptor complexed with deletion mutant of human Atrial Natriuretic Peptide[5-27]
Ogawa H
To be published
Assembly composition: protein/protein complex
Bound ligands: CL   
Carbohydrate polymer components:
Molecule 1 - MAN(1), NAG(2)
Molecule 2 - MAN(2), NAG(2)
Assembly name: ANPR-A receptor complex and Atrial natriuretic peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-134081 (Preferred)   search this ID
PDBe-KB: P01160    P18910   
X-ray diffraction
2.85Å resolution
Released: 31 Mar 2021
Model geometry
Fit model/data
7brk
7brk
7brk
Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381
Franklin MC, Romero Hernandez A
Nature (2024) [PMID: 39261724  ]
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Molecule 2 - BMA(1), MAN(2), NAG(2)
Molecule 3 - BMA(1), MAN(1), NAG(2)
Assembly name: ANPR-A receptor complex and Atrial natriuretic peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-272023 (Preferred)   search this ID
PDBe-KB: P01160    P16066   
Electron Microscopy
3.08Å resolution
Released: 17 Jul 2024
Model geometry
Fit model/data
Data not analysed
8tg9
8tg9
8tg9
Atrial Natriuretic Peptide Receptor complexed with deletion mutant of human Atrial Natriuretic Peptide[7-28]
Ogawa H
To be published
Assembly composition: protein/protein complex
Bound ligands: CL   
Carbohydrate polymer components:
Molecule 1 - MAN(1), NAG(2)
Molecule 2 - MAN(2), NAG(2)
Assembly name: ANPR-A receptor complex and Atrial natriuretic peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-134081 (Preferred)   search this ID
PDBe-KB: P01160    P18910   
X-ray diffraction
2.7Å resolution
Released: 31 Mar 2021
Model geometry
Fit model/data
7brj
7brj
7brj
Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)
Funke T, Guo Q, Tang W-J
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Assembly name: Atrial natriuretic peptide and Insulin-degrading enzyme (Preferred)   search this complex
PDBe complex ID: PDB-CPX-134082 (Preferred)   search this ID
PDBe-KB: P01160    P14735   
X-ray diffraction
3.03Å resolution
Released: 17 Nov 2010
Model geometry
Fit model/data
3n57
3n57
3n57
SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR
Fairbrother WJ, Mcdowell RS, Cunningham BC
Biochemistry (1994) [PMID: 8043577  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Atrial natriuretic peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-134079 (Preferred)   search this ID
PDBe-KB: P01160   
Solution NMR
Released: 7 Apr 1995
Model geometry
Fit model/data
Data not deposited
1anp
1anp
1anp
structure of natriuretic peptide receptor-C complexed with atrial natriuretic peptide
He X, Garcia KC
J Mol Biol (2006) [PMID: 16870210  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: NAG    CL    NAG   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Assembly name: Atrial natriuretic peptide and Atrial natriuretic peptide receptor 3 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-134080 (Preferred)   search this ID
PDBe-KB: P01160    P17342   
X-ray diffraction
2.4Å resolution
Released: 18 Apr 2006
Model geometry
Fit model/data
1yk0
1yk0
1yk0
Entries 1 to 8 of 8
Entries 1 to 8 of 8