Filter by :
Entry Information
Entry status
(1)
Experimental methods
(3)
X-ray diffraction
(12)
Electron Microscopy
(3)
Solution NMR
(2)
Authors
(160)
Stahl M
(3)
Adams R
(2)
Bellon JS
(2)
Bellón JS
(2)
Blanchetot C
(2)
Borshchevskiy V
(2)
Bubeck D
(2)
Bukhdruker S
(2)
Burtseva A
(2)
Cambillau C
(2)
Carter JD
(2)
Clifton MC
(2)
Cumming DA
(2)
Davies D
(2)
Davies DR
(2)
Desmyter A
(2)
Edwards T
(2)
Edwards TE
(2)
Eliseev I
(2)
Fyfe PK
(2)
Gardner S
(2)
Gelinas A
(2)
Gelinas AD
(2)
Gordeliy V
(2)
Gupta S
(2)
Gushchin I
(2)
Hirota M
(2)
Hong J
(2)
Hultberg A
(2)
Ischenko A
(2)
Ishikawa Y
(2)
Janjic N
(2)
Jarvis T
(2)
Jarvis TC
(2)
Jin Y
(2)
Kay LE
(2)
Klarenbeek A
(2)
Kretz-Rommel A
(2)
Marin E
(2)
McDonagh T
(2)
Mcdonagh T
(2)
Meier C
(2)
Mishin A
(2)
Moraga I
(2)
Nakaishi Y
(2)
Ongenae N
(2)
Petrov A
(2)
Piehler J
(2)
Pigareva N
(2)
Pohler E
(2)
Rapecki S
(2)
Remeeva A
(2)
Rodin S
(2)
Rohloff JC
(2)
Shishkin P
(2)
Sokolov A
(2)
Spinelli S
(2)
Voisin TB
(2)
Xu GY
(2)
Yu HA
(2)
Yudenko A
(2)
Zhang C
(2)
Zinovev E
(2)
Baker T
(1)
Baker TS
(1)
Becker S
(1)
Boos I
(1)
Boulanger MJ
(1)
Bourne T
(1)
Bretscher C
(1)
Brevnova EE
(1)
Burnley RJ
(1)
Cao J
(1)
Carrington B
(1)
Cheong HK
(1)
Choi J
(1)
Chow DC
(1)
De Jonge N
(1)
De haard HJW
(1)
Del Carmen Lopez M
(1)
Doyle C
(1)
Dreier T
(1)
Ettorre A
(1)
Fischer JP
(1)
Franklin MC
(1)
Garbers C
(1)
Garcia KC
(1)
Gelinas R
(1)
Glatman Zaretsky A
(1)
Graf C
(1)
Griffin LM
(1)
Griffin R
(1)
Hallstein K
(1)
Haxhinasto S
(1)
Hemrika W
(1)
Henry A
(1)
Heu W
(1)
Hofman E
(1)
Jo EK
(1)
Kim D
(1)
More...
Homo / hetero assembly
(2)
hetero
(13)
homo
(4)
Assembly composition
(3)
protein/protein complex
(11)
protein structure
(4)
DNA/protein complex
(2)
Assembly polymer count
(5)
hexamer
(6)
trimer
(4)
dimer
(3)
monomer
(3)
tetramer
(1)
Resolution distribution
1.5 - 2
(2)
2.0 - 2.5
(4)
2.5 - 3
(5)
3.0 - 3.5
(3)
3.5 - 4
(1)
Release year distribution
1995 - 2000
(3)
2000 - 2005
(1)
2010 - 2015
(5)
2015 - 2020
(3)
2020 - 2025
(6)
Journal
(11)
J Biol Chem
(3)
J Mol Biol
(2)
Nat Commun
(2)
Structure
(2)
To be published
(2)
Angew Chem Int Ed Engl
(1)
EMBO J
(1)
MAbs
(1)
Sci Adv
(1)
Sci Rep
(1)
Science
(1)
Macromolecules
Organism superkingdom
(2)
Eukaryota
(17)
Bacteria
(1)
Organism name
(5)
Homo sapiens
(17)
Mus musculus
(2)
Eptatretus burgeri
(1)
Listeria monocytogenes
(1)
synthetic construct
(1)
Molecule name
(33)
B-cell stimulatory factor 2
(17)
BSF-2
(17)
CDF
(17)
CTL differentiation factor
(17)
Hybridoma growth factor
(17)
IFN-beta-2
(17)
IL-6
(17)
Interferon beta-2
(17)
Interleukin-6
(17)
IL-6 receptor subunit alpha
(5)
IL-6R 1
(5)
IL-6R subunit alpha
(5)
IL-6R-alpha
(5)
IL-6RA
(5)
Interleukin-6 receptor subunit alpha
(5)
Membrane glycoprotein 80
(5)
Soluble interleukin-6 receptor subunit alpha
(5)
gp80
(5)
sIL6R
(5)
IL-6 receptor subunit beta
(4)
IL-6R subunit beta
(4)
IL-6R-beta
(4)
IL-6RB
(4)
Interleukin-6 receptor subunit beta
(4)
Interleukin-6 signal transducer
(4)
Membrane glycoprotein 130
(4)
Oncostatin-M receptor subunit alpha
(4)
gp130
(4)
CDw130
(2)
GW domain-containing protein
(1)
Internalin B
(1)
LRRNT domain-containing protein
(1)
Variable lymphocyte receptor B
(1)
Molecule type
(1)
Protein
(17)
Gene names
(6)
IFNB2
(17)
IL6
(17)
IL6R
(5)
IL6ST
(2)
Il6st
(2)
VLRB
(1)
Interacting Molecules
(18)
Interleukin-6
(6)
Interleukin-6 receptor subunit beta
(4)
Soluble interleukin-6 receptor subunit alpha
(3)
Interleukin-6 receptor subunit alpha
(2)
SOMAmer SL1025
(2)
GW domain-containing protein
(1)
Heavy Chain of the Camelid Fab fragment 61H7
(1)
Heavy chain of the Fab fragment of anti-IL-6 antibody 68F2
(1)
Heavy chain of the Fab fragment of anti-IL-6 antibody I9H
(1)
LRRNT domain-containing protein
(1)
Light Chain of the Camelid Fab fragment 61H7
(1)
Light chain of the Fab fragment of anti-IL-6 antibody 68F2
(1)
Light chain of the Fab fragment of anti-IL-6 antibody I9H
(1)
Llama Fab fragment 68F2 heavy chain
(1)
Llama Fab fragment 68F2 light chain
(1)
OLOKIZUMAB HEAVY CHAIN, FAB PORTION
(1)
OLOKIZUMAB LIGHT CHAIN, FAB PORTION
(1)
VHH6
(1)
Interacting ligands
(4)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(4)
SO4 : SULFATE ION
(2)
MG : MAGNESIUM ION
(1)
TLA : L(+)-TARTARIC ACID
(1)
Function and Biology
Biological function
(7)
cytokine activity
(16)
interleukin-6 receptor binding
(16)
growth factor activity
(7)
identical protein binding
(7)
protein binding
(7)
signaling receptor binding
(7)
cytokine receptor activity
(5)
Biological process
(93)
cell differentiation
(15)
immune response
(15)
T follicular helper cell differentiation
(7)
T-helper 17 cell lineage commitment
(7)
acute-phase response
(7)
cell surface receptor signaling pathway via JAK-STAT
(7)
cell surface receptor signaling pathway via STAT
(7)
cellular response to hydrogen peroxide
(7)
cellular response to lipopolysaccharide
(7)
cellular response to virus
(7)
cytokine-mediated signaling pathway
(7)
defense response to Gram-negative bacterium
(7)
defense response to Gram-positive bacterium
(7)
defense response to virus
(7)
endocrine pancreas development
(7)
germinal center B cell differentiation
(7)
glucagon secretion
(7)
glucose homeostasis
(7)
hepatic immune response
(7)
hepatocyte proliferation
(7)
humoral immune response
(7)
inflammatory response
(7)
inflammatory response to wounding
(7)
interleukin-6-mediated signaling pathway
(7)
liver regeneration
(7)
maintenance of blood-brain barrier
(7)
monocyte chemotaxis
(7)
negative regulation of apoptotic process
(7)
negative regulation of bone resorption
(7)
negative regulation of cell population proliferation
(7)
negative regulation of chemokine production
(7)
negative regulation of collagen biosynthetic process
(7)
negative regulation of fat cell differentiation
(7)
negative regulation of interleukin-1-mediated signaling pathway
(7)
negative regulation of lipid storage
(7)
negative regulation of neurogenesis
(7)
negative regulation of primary miRNA processing
(7)
neuron cellular homeostasis
(7)
neuron projection development
(7)
neutrophil apoptotic process
(7)
neutrophil mediated immunity
(7)
platelet activation
(7)
positive regulation of B cell activation
(7)
positive regulation of DNA-binding transcription factor activity
(7)
positive regulation of DNA-templated transcription
(7)
positive regulation of MAPK cascade
(7)
positive regulation of T cell proliferation
(7)
positive regulation of T-helper 2 cell cytokine production
(7)
positive regulation of acute inflammatory response
(7)
positive regulation of apoptotic DNA fragmentation
(7)
positive regulation of apoptotic process
(7)
positive regulation of cell population proliferation
(7)
positive regulation of chemokine production
(7)
positive regulation of cytokine production involved in inflammatory response
(7)
positive regulation of epithelial to mesenchymal transition
(7)
positive regulation of extracellular matrix disassembly
(7)
positive regulation of gene expression
(7)
positive regulation of glial cell proliferation
(7)
positive regulation of immunoglobulin production
(7)
positive regulation of interleukin-1 beta production
(7)
positive regulation of interleukin-10 production
(7)
positive regulation of interleukin-17 production
(7)
positive regulation of interleukin-21 production
(7)
positive regulation of interleukin-6 production
(7)
positive regulation of interleukin-8 production
(7)
positive regulation of leukocyte adhesion to vascular endothelial cell
(7)
positive regulation of leukocyte chemotaxis
(7)
positive regulation of miRNA transcription
(7)
positive regulation of multicellular organismal process
(7)
positive regulation of neuroinflammatory response
(7)
positive regulation of osteoblast differentiation
(7)
positive regulation of peptidyl-serine phosphorylation
(7)
positive regulation of peptidyl-tyrosine phosphorylation
(7)
positive regulation of platelet aggregation
(7)
positive regulation of receptor signaling pathway via JAK-STAT
(7)
positive regulation of receptor signaling pathway via STAT
(7)
positive regulation of smooth muscle cell proliferation
(7)
positive regulation of transcription by RNA polymerase II
(7)
positive regulation of translation
(7)
positive regulation of tumor necrosis factor production
(7)
positive regulation of type B pancreatic cell apoptotic process
(7)
positive regulation of vascular endothelial growth factor production
(7)
regulation of angiogenesis
(7)
regulation of astrocyte activation
(7)
regulation of glucagon secretion
(7)
regulation of insulin secretion
(7)
regulation of microglial cell activation
(7)
regulation of neuroinflammatory response
(7)
regulation of vascular endothelial growth factor production
(7)
response to activity
(7)
response to glucocorticoid
(7)
response to peptidoglycan
(7)
vascular endothelial growth factor production
(7)
Biological cell component
(5)
extracellular region
(16)
extracellular space
(16)
endoplasmic reticulum lumen
(7)
interleukin-6 receptor complex
(7)
membrane
(5)
Sequence and Structure classification
SCOP fold
(2)
4-helical cytokines
(4)
Immunoglobulin-like beta-sandwich
(1)
SCOP family
(2)
Long-chain cytokines
(4)
Fibronectin type III
(1)
CATH class
(3)
Mainly Alpha
(11)
Mainly Beta
(2)
Alpha Beta
(1)
CATH topology
(3)
Growth Hormone; Chain: A;
(11)
Immunoglobulin-like
(2)
Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
(1)
Pfam accession / name
(8)
PF00489 : IL6
(17)
PF09240 : IL6Ra-bind
(5)
PF00041 : fn3
(4)
PF06328 : Lep_receptor_Ig
(4)
PF00047 : ig
(3)
PF11921 : DUF3439
(1)
PF12354 : Internalin_N
(1)
PF13855 : LRR_8
(1)
Experimental Information
Diffraction protocol
(1)
Single wavelength
(11)
Diffraction radiation source type
(2)
Synchrotron
(11)
Rotating anode
(1)
Diffraction source
(9)
APS BEAMLINE 21-ID-D
(2)
ESRF BEAMLINE ID14-4
(2)
SOLEIL BEAMLINE PROXIMA 1
(2)
ALS BEAMLINE 8.2.1
(1)
BESSY BEAMLINE 14.1
(1)
DIAMOND BEAMLINE I02
(1)
PHOTON FACTORY BEAMLINE BL-1A
(1)
RIGAKU RUH2R
(1)
SLS BEAMLINE X06SA
(1)
Synchrotron site
(8)
APS
(2)
ESRF
(2)
SOLEIL
(2)
ALS
(1)
BESSY
(1)
Diamond
(1)
Photon Factory
(1)
SLS
(1)
Diffraction detector type
(3)
CCD
(7)
Pixel
(3)
Image plate
(1)
Refinement software
(5)
REFMAC
(6)
BUSTER
(3)
CNS
(3)
PHENIX
(3)
X-PLOR
(2)
EM microscope model
(1)
FEI TITAN KRIOS
(3)
EM detector name
(2)
GATAN K3 (6k x 4k)
(2)
GATAN K3 BIOQUANTUM (6k x 4k)
(1)
NMR
NMR software packages
(1)
X-PLOR
(2)
NMR Field Strength
500.0 - 600
(2)
600.0 - 700
(2)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 17
Select all entries on this page
Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies
Adams R, Griffin R, Doyle C, Ettorre A
Sci Rep
(2017)
[PMID: 28134246 ]
Source organisms: Camelus dromedarius , Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-209240 (Preferred)
search this ID
Modular evolution and design of the protein binding interface
Cheong HK, Kim HJ
To be published
Assembly composition: protein/protein complex
Assembly name:
GW domain-containing protein, LRRNT domain-containing protein and Interleukin-6
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-107391 (Preferred)
search this ID
Structure of interleukin 6 (gp130 P496L mutant).
Gardner S, Bubeck D, Jin Y
Nat Commun
(2024)
[PMID: 38453915 ]
Source organisms: Mus musculus , Homo sapiens
Assembly composition: protein/protein complex
Carbohydrate polymer components:
Molecule 1 -
NAG(2)
Assembly name:
Interleukin-6 antagonist complex
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-272320 (Preferred)
search this ID
Structure of interleukin 6.
Gardner S, Bubeck D, Jin Y
Nat Commun
(2024)
[PMID: 38453915 ]
Source organisms: Mus musculus , Homo sapiens
Assembly composition: protein/protein complex
Carbohydrate polymer components:
Molecule 1 -
NAG(2)
Assembly name:
Interleukin-6 antagonist complex
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-272320 (Preferred)
search this ID
Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex
Boulanger MJ, Chow DC, Brevnova EE, Garcia KC
Science
(2003)
[PMID: 12829785 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Interleukin 6-mIL6R-mIL6ST receptor-ligand classical signalling complex
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-138620 (Preferred)
search this ID
Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full extracellular domains
Zhou Y, Franklin MC
Sci Adv
(2023)
[PMID: 36930708 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Carbohydrate polymer components:
Molecule 1 -
NAG(2)
Assembly name:
Interleukin 6-mIL6R-mIL6ST receptor-ligand classical signalling complex
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-138620 (Preferred)
search this ID
HUMAN INTERLEUKIN-6, NMR, 32 STRUCTURES
Xu GY, Yu HA, Hong J, Stahl M, Mcdonagh T, Kay LE, Cumming DA
J Mol Biol
(1997)
[PMID: 9159484 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Interleukin-6
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-138614 (Preferred)
search this ID

HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE
Xu GY, Yu HA, Hong J, Stahl M, Mcdonagh T, Kay LE, Cumming DA
J Mol Biol
(1997)
[PMID: 9159484 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Interleukin-6
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-138614 (Preferred)
search this ID

Structure of Interleukin-6 in complex with a Camelid Fab fragment
Klarenbeek A, Blanchetot C, Schragel G, Sadi AS, Ongenae N, Hemrika W, Wijdenes J, Spinelli S, Desmyter A, Cambillau C, Hultberg A, Kretz-rommel A, Dreier T, De haard HJW, Roovers RC
To be published
Source organisms: Lama glama , Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Interleukin-6 and IG-heavy chain and IG-light lambda chain
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-209242 (Preferred)
search this ID

HUMAN INTERLEUKIN-6
Somers WS, Stahl M, Seehra JS
EMBO J
(1997)
[PMID: 9118960 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Interleukin-6 antagonist complex
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-138619 (Preferred)
search this ID

Entries 1 to 10 of 17