Uniprot accession / id : P06151  OR   Uniprot accession / id : P00338  OR   Uniprot accession / id : F5GXY2
 
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Entry Information
Entry status  (1)
REL
(45)
 
Experimental methods  (1)
X-ray diffraction
(45)
 
Authors  (234)
Eigenbrot C
(20)
Corson LB
(19)
Ultsch M
(19)
Wei B
(19)
Chen J
(18)
Malek S
(18)
Peterson D
(18)
Robarge K
(18)
Sideris S
(18)
Yen I
(18)
Ding CZ
(17)
Dragovich PS
(17)
Fauber BP
(17)
Purkey HE
(17)
Yue Q
(17)
Zhou A
(16)
Ge H
(15)
Ma S
(15)
Salphati L
(15)
Zhang H
(15)
Liu Y
(14)
Ho Q
(12)
Labadie SS
(12)
Lai KW
(12)
Li C
(12)
Chen Z
(11)
Evangelista M
(11)
Hitz A
(11)
O'Brien T
(11)
Pang J
(11)
DiPasquale AG
(10)
Liu W
(10)
Labadie S
(8)
Benavides GA
(7)
Brimacombe KR
(7)
Cheff DM
(7)
Dang CV
(7)
Darley-Usmar VM
(7)
Davies DR
(7)
Dranow DM
(7)
Flint AJ
(7)
Goa Z
(7)
Hall MD
(7)
Hu X
(7)
Jadhav A
(7)
Lee TD
(7)
Maloney DJ
(7)
Moore WJ
(7)
Mott BT
(7)
Pohida K
(7)
Rai G
(7)
Simeonov A
(7)
Stott GM
(7)
Urban DJ
(7)
Waterson AG
(7)
Yang SM
(7)
Zhu H
(7)
VanderPorten E
(6)
Kouznetsova J
(5)
Kuenstner EJ
(5)
Luci DK
(5)
Lukacs CM
(5)
Neckers LM
(5)
Sulikowski G
(5)
Xu Q
(5)
Zhang X
(5)
Boggs J
(4)
Craig L
(4)
Giannetti AM
(4)
Hunsaker T
(4)
Kolappan S
(4)
McEachern EJ
(4)
Mosi R
(4)
Shen DL
(4)
Sun J
(4)
Vocadlo DJ
(4)
Choi H-J
(3)
Choi HJ
(3)
Chung T-W
(3)
Chung TW
(3)
Gao Z
(3)
Ha K-T
(3)
Ha KT
(3)
Han CW
(3)
Jang SB
(3)
Jeong MS
(3)
Jin L
(3)
Kim E-Y
(3)
Kim EY
(3)
Kim K-J
(3)
Kim KJ
(3)
Kim S
(3)
Kwon YJ
(3)
Lee H
(3)
Park KH
(3)
Park M-J
(3)
Park MJ
(3)
Park SY
(3)
Wang J
(3)
Yoon D
(3)
 
More...
 
Homo / hetero assembly  (1)
homo
(45)
 
Assembly composition  (1)
protein structure
(45)
 
Assembly polymer count  (1)
tetramer
(45)
 
Resolution distribution
1.5 - 2
(11)
2.0 - 2.5
(23)
2.5 - 3
(9)
3.0 - 3.5
(2)
 
Release year distribution
2000 - 2005
(1)
2010 - 2015
(14)
2015 - 2020
(26)
2020 - 2025
(9)
 
Journal  (11)
To be published
(12)
J Med Chem
(8)
Bioorg Med Chem Lett
(7)
Acta Crystallogr D Biol Crystallogr
(6)
Cancers (Basel)
(3)
ACS Med Chem Lett
(2)
ACS Omega
(2)
Eur J Med Chem
(2)
ACS Medicinal Chemistry Letters
(1)
Nat Chem Biol
(1)
Proteins
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(45)
 
Organism name  (1)
Homo sapiens
(45)
 
Molecule name  (6)
Cell proliferation-inducing gene 19 protein
(45)
L-lactate dehydrogenase A chain
(45)
LDH muscle subunit
(45)
LDH-A
(45)
LDH-M
(45)
Renal carcinoma antigen NY-REN-59
(45)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 45
Entries 1 to 10 of 45
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Human Lactate Dehydrogenase A in Complex with Inhibitor CHK-336
Lowther WT, Gumpena R
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NAI    PEG    YBO    PEG    YBO    EDO   
Assembly name: L-lactate dehydrogenase A complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132412 (Preferred)   search this ID
PDBe-KB: P00338   
X-ray diffraction
2.34Å resolution
Released: 24 Jan 2024
Model geometry
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8fw6
8fw6
8fw6
LDHA structure in complex with inhibitor 14
Eigenbrot CE, Ultsch M, Wei B
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NAI    D3S    D3S    SO4    EPE    LAC   
Assembly name: L-lactate dehydrogenase A complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132412 (Preferred)   search this ID
PDBe-KB: P00338   
X-ray diffraction
1.95Å resolution
Released: 30 Oct 2019
Model geometry
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6mv8
6mv8
6mv8
LDHA-mla
Han CW, Jang SB
Cancers (Basel) (2019) [PMID: 31324019  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MLI   
Assembly name: L-lactate dehydrogenase A complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132412 (Preferred)   search this ID
PDBe-KB: P00338   
X-ray diffraction
2.929Å resolution
Released: 24 Jul 2019
Model geometry
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5zje
5zje
5zje
Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 9: (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one
Ultsch M, Eigenbrot C
ACS Med Chem Lett (2016) [PMID: 27774125  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NAI    6EY    TXD    6EY    SO4    EPE   
Assembly name: L-lactate dehydrogenase A complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132412 (Preferred)   search this ID
PDBe-KB: P00338   
X-ray diffraction
2.05Å resolution
Released: 14 Sep 2016
Model geometry
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5ixs
5ixs
5ixs
Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 29 and NADH
Lukacs CM, Dranow DM
J Med Chem (2017) [PMID: 29120638  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NAI    9Y7    GOL    MLA    9Y7   
Assembly name: L-lactate dehydrogenase A complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132412 (Preferred)   search this ID
PDBe-KB: P00338   
X-ray diffraction
1.6Å resolution
Released: 17 Jan 2018
Model geometry
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5w8k
5w8k
5w8k
Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 23 and Zinc
Lukacs CM, Abendroth J
J Med Chem (2017) [PMID: 29120638  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CIT    9YD    GOL    ZN    DMS    9YD    DMS    MLA    ZN   
Assembly name: L-lactate dehydrogenase A complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132412 (Preferred)   search this ID
PDBe-KB: P00338   
X-ray diffraction
1.95Å resolution
Released: 17 Jan 2018
Model geometry
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5w8i
5w8i
5w8i
Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 31: (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one
Chen Z, Eigenbrot C
ACS Med Chem Lett (2016) [PMID: 27774125  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GN2    NAD    SO4   
Assembly name: L-lactate dehydrogenase A complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132412 (Preferred)   search this ID
PDBe-KB: P00338   
X-ray diffraction
3Å resolution
Released: 14 Sep 2016
Model geometry
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5ixy
5ixy
5ixy
Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 59 and NADH
Davies DR, Dranow DM
J Med Chem (2017) [PMID: 29120638  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NAI    9YA    9YA    EDO   
Assembly name: L-lactate dehydrogenase A complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132412 (Preferred)   search this ID
PDBe-KB: P00338   
X-ray diffraction
1.95Å resolution
Released: 17 Jan 2018
Model geometry
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5w8l
5w8l
5w8l
Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 29
Lukacs CM, Moulin A
J Med Chem (2017) [PMID: 29120638  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 9Y7    GOL    DMS    DMS    MLA    9Y7   
Assembly name: L-lactate dehydrogenase A complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132412 (Preferred)   search this ID
PDBe-KB: P00338   
X-ray diffraction
1.55Å resolution
Released: 17 Jan 2018
Model geometry
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5w8j
5w8j
5w8j
Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 11
Lukacs CM, Dranow DM
J Med Chem (2017) [PMID: 29120638  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ACT    GOL    DMS    DMS    MLA    9Y1    9Y1    ACT   
Assembly name: L-lactate dehydrogenase A complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-132412 (Preferred)   search this ID
PDBe-KB: P00338   
X-ray diffraction
1.8Å resolution
Released: 17 Jan 2018
Model geometry
Fit model/data
5w8h
5w8h
5w8h
Entries 1 to 10 of 45
Entries 1 to 10 of 45