Uniprot accession / id : P06744  OR   Uniprot accession / id : A0A0J9YYH3
 
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Entry Information
Entry status  (1)
REL
(13)
 
Experimental methods  (2)
X-ray diffraction
(12)
Electron Microscopy
(1)
 
Authors  (73)
Hjorleifsson GJ
(4)
Hjorleifsson JG
(4)
Hjörleifsson JG
(4)
Jonatansdottir YY
(4)
Jónatansdóttir YY
(4)
Rolfsson O
(4)
Rolfsson Ó
(4)
Ahmad L
(2)
Akiyama H
(2)
Chirgwin J
(2)
Davies C
(2)
Funasaka T
(2)
Haga A
(2)
Korri-Youssoufi H
(2)
Lazar N
(2)
Li de la Sierra-Gallay I
(2)
Muirhead H
(2)
Nagase H
(2)
Nakamura KT
(2)
Plancqueel S
(2)
Raz A
(2)
Salmon L
(2)
Tanaka N
(2)
Uemura H
(2)
van Tilbeurgh H
(2)
Ban N
(1)
Bergstrom G
(1)
Bergström G
(1)
Cheng L
(1)
Cordeiro AT
(1)
Deuerling E
(1)
Diederichs K
(1)
Fernandez G
(1)
Forslind K
(1)
Gamerdinger M
(1)
Garratt RC
(1)
Ge C
(1)
Gjertsson I
(1)
Godoi PH
(1)
Godoi PHC
(1)
Holmdahl R
(1)
Hunaeus G
(1)
Jaskolowski M
(1)
Jia M
(1)
Johansson L
(1)
Jomaa A
(1)
Kastbom A
(1)
Khakzar KM
(1)
Kramer A
(1)
Krämer A
(1)
Leu Agelii M
(1)
Li Q
(1)
Li T
(1)
Li X
(1)
Lonnblom E
(1)
Lönnblom E
(1)
Oliva G
(1)
Pearce J
(1)
Rabl L
(1)
Rantapaa-Dahlqvist S
(1)
Rantapää-Dahlqvist S
(1)
Read J
(1)
Read JA
(1)
Sareila O
(1)
Scaiola A
(1)
Schloemer R
(1)
Silva CH
(1)
Silva CHTP
(1)
Thiemann OH
(1)
Ulusoy Z
(1)
Wallisch A
(1)
Xu B
(1)
Yang M
(1)
 
Homo / hetero assembly  (2)
homo
(11)
hetero
(2)
 
Assembly composition  (3)
protein structure
(11)
RNA/protein complex
(1)
protein/protein complex
(1)
 
Assembly polymer count  (3)
dimer
(11)
88-mer
(1)
trimer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(7)
2.0 - 2.5
(3)
2.5 - 3
(2)
 
Release year distribution
2000 - 2005
(5)
2015 - 2020
(2)
2020 - 2025
(8)
2025 - 2030
(4)
 
Journal  (7)
FEBS J
(4)
J Mol Biol
(3)
Bioorg Chem
(2)
Acta Crystallogr D Biol Crystallogr
(1)
Ann Rheum Dis
(1)
Biochim Biophys Acta
(1)
Science
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(13)
 
Organism name  (2)
Homo sapiens
(12)
Oryctolagus cuniculus
(1)
 
Molecule name  (12)
AMF
(13)
Autocrine motility factor
(13)
GPI
(13)
Glucose-6-phosphate isomerase
(13)
NLK
(13)
Neuroleukin
(13)
PGI
(13)
PHI
(13)
Phosphoglucose isomerase
(13)
Phosphohexose isomerase
(13)
SA-36
(13)
Sperm antigen 36
(13)
 
Molecule type  (1)
Protein
(13)
 
Gene names  (1)
GPI
(13)
 
Interacting Molecules  (89)
18s rRNA
(1)
28S ribosomal RNA
(1)
40S ribosomal protein S24
(1)
40S ribosomal protein S26
(1)
5.8S ribosomal RNA
(1)
5S ribosomal RNA
(1)
E-site tRNA
(1)
Heavy Chain of TL1 Fab fragment
(1)
Large ribosomal subunit protein eL13
(1)
Large ribosomal subunit protein eL14
(1)
Large ribosomal subunit protein eL15
(1)
Large ribosomal subunit protein eL19
(1)
Large ribosomal subunit protein eL20
(1)
Large ribosomal subunit protein eL21
(1)
Large ribosomal subunit protein eL22
(1)
Large ribosomal subunit protein eL24
(1)
Large ribosomal subunit protein eL27
(1)
Large ribosomal subunit protein eL28
(1)
Large ribosomal subunit protein eL29
(1)
Large ribosomal subunit protein eL30
(1)
Large ribosomal subunit protein eL31
(1)
Large ribosomal subunit protein eL32
(1)
Large ribosomal subunit protein eL33
(1)
Large ribosomal subunit protein eL34
(1)
Large ribosomal subunit protein eL36
(1)
Large ribosomal subunit protein eL37
(1)
Large ribosomal subunit protein eL38
(1)
Large ribosomal subunit protein eL39
(1)
Large ribosomal subunit protein eL42
(1)
Large ribosomal subunit protein eL43
(1)
Large ribosomal subunit protein eL6
(1)
Large ribosomal subunit protein eL8
(1)
Large ribosomal subunit protein uL1
(1)
Large ribosomal subunit protein uL10
(1)
Large ribosomal subunit protein uL11
(1)
Large ribosomal subunit protein uL13
(1)
Large ribosomal subunit protein uL14
(1)
Large ribosomal subunit protein uL15
(1)
Large ribosomal subunit protein uL15/eL18 domain-containing protein
(1)
Large ribosomal subunit protein uL16
(1)
Large ribosomal subunit protein uL18
(1)
Large ribosomal subunit protein uL2
(1)
Large ribosomal subunit protein uL22
(1)
Large ribosomal subunit protein uL23
(1)
Large ribosomal subunit protein uL24
(1)
Large ribosomal subunit protein uL29
(1)
Large ribosomal subunit protein uL3
(1)
Large ribosomal subunit protein uL30
(1)
Large ribosomal subunit protein uL4
(1)
Large ribosomal subunit protein uL5
(1)
Large ribosomal subunit protein uL6
(1)
Light Chain of TL1 Fab fragment
(1)
Methionine aminopeptidase 1
(1)
Nascent polypeptide-associated complex subunit alpha
(1)
P-site Val-tRNA
(1)
Small ribosomal subunit protein RACK1
(1)
Small ribosomal subunit protein eS1
(1)
Small ribosomal subunit protein eS10
(1)
Small ribosomal subunit protein eS12
(1)
Small ribosomal subunit protein eS17
(1)
Small ribosomal subunit protein eS19
(1)
Small ribosomal subunit protein eS21
(1)
Small ribosomal subunit protein eS25
(1)
Small ribosomal subunit protein eS27
(1)
Small ribosomal subunit protein eS28
(1)
Small ribosomal subunit protein eS32
(1)
Small ribosomal subunit protein eS4
(1)
Small ribosomal subunit protein eS6
(1)
Small ribosomal subunit protein eS7
(1)
Small ribosomal subunit protein eS8
(1)
Small ribosomal subunit protein uS10
(1)
Small ribosomal subunit protein uS11
(1)
Small ribosomal subunit protein uS12
(1)
Small ribosomal subunit protein uS13
(1)
Small ribosomal subunit protein uS14
(1)
Small ribosomal subunit protein uS15
(1)
Small ribosomal subunit protein uS17
(1)
Small ribosomal subunit protein uS19
(1)
Small ribosomal subunit protein uS2
(1)
Small ribosomal subunit protein uS3
(1)
Small ribosomal subunit protein uS4
(1)
Small ribosomal subunit protein uS5
(1)
Small ribosomal subunit protein uS7
(1)
Small ribosomal subunit protein uS8
(1)
Small ribosomal subunit protein uS9
(1)
Transcription factor BTF3
(1)
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
(1)
Ubiquitin-ribosomal protein eL40 fusion protein
(1)
Ubiquitin-ribosomal protein eS31 fusion protein
(1)
 
Interacting ligands  (16)
PA5 : 5-PHOSPHOARABINONIC ACID
(3)
PGE : TRIETHYLENE GLYCOL
(3)
BME : BETA-MERCAPTOETHANOL
(2)
PEG : DI(HYDROXYETHYL)ETHER
(2)
PG4 : TETRAETHYLENE GLYCOL
(2)
SO4 : SULFATE ION
(2)
TRS : 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
(2)
13P : 1,3-DIHYDROXYACETONEPHOSPHATE
(1)
1PE : PENTAETHYLENE GLYCOL
(1)
CIZ : (~{Z})-2-methylbut-2-enedioic acid
(1)
E4P : ERYTHOSE-4-PHOSPHATE
(1)
GOL : GLYCEROL
(1)
MAE : MALEIC ACID
(1)
O1B : (2R,3R,4S)-5-((2-aminoethyl)amino)-2,3,4-trihydroxy-5-oxopentyl dihydrogen phosphate
(1)
PEP : PHOSPHOENOLPYRUVATE
(1)
PG6 : 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE
(1)
 
Function and Biology
EC number / name  (1)
5.3.1.9 : Glucose-6-phosphate isomerase
(13)
 
Biological function  (8)
carbohydrate derivative binding
(8)
cytokine activity
(7)
glucose-6-phosphate isomerase activity
(7)
growth factor activity
(7)
isomerase activity
(7)
monosaccharide binding
(7)
protein binding
(7)
ubiquitin protein ligase binding
(7)
 
Biological process  (24)
carbohydrate derivative metabolic process
(8)
canonical glycolysis
(7)
carbohydrate metabolic process
(7)
erythrocyte homeostasis
(7)
fructose 6-phosphate metabolic process
(7)
gluconeogenesis
(7)
glucose 6-phosphate metabolic process
(7)
glucose homeostasis
(7)
glycolytic process
(7)
hemostasis
(7)
humoral immune response
(7)
in utero embryonic development
(7)
learning or memory
(7)
mesoderm formation
(7)
negative regulation of apoptotic process
(7)
positive regulation of endothelial cell migration
(7)
positive regulation of immunoglobulin production
(7)
response to cadmium ion
(7)
response to estradiol
(7)
response to immobilization stress
(7)
response to muscle stretch
(7)
response to progesterone
(7)
response to testosterone
(7)
signal transduction
(7)
 
Biological cell component  (10)
ciliary membrane
(7)
cytoplasm
(7)
cytosol
(7)
extracellular exosome
(7)
extracellular region
(7)
extracellular space
(7)
ficolin-1-rich granule lumen
(7)
membrane
(7)
plasma membrane
(7)
secretory granule lumen
(7)
 
Sequence and Structure classification
SCOP fold  (1)
SIS domain
(5)
 
SCOP family  (1)
Phosphoglucose isomerase, PGI
(5)
 
CATH class  (2)
Alpha Beta
(5)
Mainly Alpha
(5)
 
CATH topology  (2)
Phosphoglucose isomerase, C-terminal domain
(5)
Rossmann fold
(5)
 
Pfam accession / name  (1)
PF00342 : PGI
(11)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(12)
 
Diffraction radiation source type  (2)
Synchrotron
(11)
Rotating anode
(1)
 
Diffraction source  (8)
MAX IV BEAMLINE BioMAX
(5)
LNLS BEAMLINE D03B-MX1
(1)
PHOTON FACTORY BEAMLINE BL-18B
(1)
PHOTON FACTORY BEAMLINE BL-6A
(1)
RIGAKU RU300
(1)
SOLEIL BEAMLINE PROXIMA 1
(1)
SOLEIL BEAMLINE PROXIMA 2
(1)
SRS BEAMLINE PX7.2
(1)
 
Synchrotron site  (5)
MAX IV
(5)
Photon Factory
(2)
SOLEIL
(2)
LNLS
(1)
SRS
(1)
 
Diffraction detector type  (3)
Pixel
(7)
Image plate
(3)
CCD
(2)
 
Refinement software  (4)
REFMAC
(11)
PHENIX
(5)
CNS
(1)
phenix.real_space_refine
(1)
 
EM microscope model  (1)
FEI TITAN KRIOS
(1)
 
EM detector name  (1)
GATAN K3 (6k x 4k)
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 13
Entries 1 to 10 of 13
 Select all entries on this page
The crystal structure of a mouse Fab fragment TL1 in complex with a human Glucose-6-phosphate isomerase peptide 293-307
Ge C, Holmdahl R, Li T
Ann Rheum Dis (2023) [PMID: 36858822  ]
Assembly composition: protein/protein complex
Modified residues: ACA   
Assembly name: Glucose-6-phosphate isomerase and IG-heavy chain and IG-light kappa chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-272371 (Preferred)   search this ID
PDBe-KB: P06744   
X-ray diffraction
1.619Å resolution
Released: 21 Dec 2022
Model geometry
Fit model/data
8bbh
8bbh
8bbh
Crystal structure of human Glucose-6-phosphate isomerase with dihydroxyacetone phosphate ligand
Jonatansdottir YY, Hjorleifsson GJ
FEBS J (2025) [PMID: 40014465  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PEG    PEG    13P    13P   
Assembly name: Glucose-6-phosphate isomerase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-139198 (Preferred)   search this ID
PDBe-KB: P06744   
X-ray diffraction
1.8Å resolution
Released: 12 Mar 2025
Model geometry
Fit model/data
9fhf
9fhf
9fhf
Crystal structure of human Glucose-6-phosphate isomerase with citraconate ligand
Jonatansdottir YY, Hjorleifsson GJ
FEBS J (2025) [PMID: 40014465  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PG4    BME    1PE    CIZ    CIZ    PG4    1PE    PGE    PGE   
Assembly name: Glucose-6-phosphate isomerase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-139198 (Preferred)   search this ID
PDBe-KB: P06744   
X-ray diffraction
1.6Å resolution
Released: 12 Mar 2025
Model geometry
Fit model/data
9fkc
9fkc
9fkc
Crystal structure of human Glucose-6-phosphate isomerase with maleate ligand
Jonatansdottir YY, Hjorleifsson GJ
FEBS J (2025) [PMID: 40014465  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MAE    PG4    MAE    TRS    PG4    TRS    PGE    PGE   
Assembly name: Glucose-6-phosphate isomerase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-139198 (Preferred)   search this ID
PDBe-KB: P06744   
X-ray diffraction
1.4Å resolution
Released: 12 Mar 2025
Model geometry
Fit model/data
9fcw
9fcw
9fcw
Crystal structure of human Glucose-6-phosphate isomerase with phosphoenol pyruvate ligand
Jonatansdottir YY, Hjorleifsson GJ
FEBS J (2025) [PMID: 40014465  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PEP    PEP    PEG    PEG    TRS    TRS    PGE    PGE   
Assembly name: Glucose-6-phosphate isomerase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-139198 (Preferred)   search this ID
PDBe-KB: P06744   
X-ray diffraction
1.6Å resolution
Released: 12 Mar 2025
Model geometry
Fit model/data
9fkf
9fkf
9fkf
Crystal structure of human phosphoglucose isomerase in complex with inhibitor
Li de la Sierra-Gallay I, Ahmad L, Plancqueel S, van Tilbeurgh H, Salmon L
Bioorg Chem (2020) [PMID: 32682158  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PA5    PA5    O1B   
Assembly name: Glucose-6-phosphate isomerase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-139198 (Preferred)   search this ID
PDBe-KB: P06744   
X-ray diffraction
2.38Å resolution
Released: 29 Jul 2020
Model geometry
Fit model/data
6xuh
6xuh
6xuh
Ternary complex of translating ribosome, NAC and METAP1
Jia M, Jaskolowski M, Scaiola A, Jomaa A, Ban N
Science (2023) [PMID: 37347872  ]
Assembly composition: RNA/protein complex
Bound ligands: SPD    MG    N    ZN    GTP    N    ZN    GTP    MG    SPM    AAC    AAC   
Modified residues: 4AC    A2M    AME    B8N    M3L    MLZ    OMC    OMG    UY1    5MC    6MZ    HIC    N    OMU    SAC    UY1    5F0    G7M    5MC    G7M    HY3    HY3    UR3    4AC    5MU    5MU    6MZ    A2M    MA6    N    SAC    1MA    AYA    HIC    MLZ    NMM    V5N    1MA    AYA    M3L    NMM    PSU    PSU    AME    MA6    OMC    OMG    OMU    UR3   
PDBe complex ID: PDB-CPX-268539 (Preferred)   search this ID
PDBe-KB: P06744    G1SK22    A0A1Z5KTU7    G1SZ47    G1T6D1    G1SIT5    (view 76 more)
Electron Microscopy
2.9Å resolution
Released: 19 Jul 2023
Model geometry
Fit model/data
Data not analysed
8p2k
8p2k
8p2k
Human Glucose-6-phosphate Isomerase
Cordeiro AT
Biochim Biophys Acta (2003) [PMID: 12573240  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Glucose-6-phosphate isomerase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-139198 (Preferred)   search this ID
PDBe-KB: P06744   
X-ray diffraction
2.1Å resolution
Released: 11 Feb 2003
Model geometry
Fit model/data
1jlh
1jlh
1jlh
Crystal structure of human autocrine motility factor complexed with an inhibitor
Tanaka N, Haga A, Uemura H, Akiyama H, Funasaka T, Nagase H, Raz A, Nakamura KT
J Mol Biol (2002) [PMID: 12054796  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: E4P    E4P   
Assembly name: Glucose-6-phosphate isomerase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-139198 (Preferred)   search this ID
PDBe-KB: P06744   
X-ray diffraction
2.4Å resolution
Released: 5 Jun 2002
Model geometry
Fit model/data
Data not deposited
1iri
1iri
1iri
The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate
Davies C
Acta Crystallogr D Biol Crystallogr (2003) [PMID: 12777791  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PA5    PA5    SO4   
Assembly name: Glucose-6-phosphate isomerase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-139198 (Preferred)   search this ID
PDBe-KB: P06744   
X-ray diffraction
2.51Å resolution
Released: 11 Feb 2003
Model geometry
Fit model/data
1nuh
1nuh
1nuh
Entries 1 to 10 of 13
Entries 1 to 10 of 13