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Entry Information
Entry status
(1)
Experimental methods
(2)
X-ray diffraction
(12)
Electron Microscopy
(1)
Authors
(73)
Hjorleifsson GJ
(4)
Hjorleifsson JG
(4)
Hjörleifsson JG
(4)
Jonatansdottir YY
(4)
Jónatansdóttir YY
(4)
Rolfsson O
(4)
Rolfsson Ó
(4)
Ahmad L
(2)
Akiyama H
(2)
Chirgwin J
(2)
Davies C
(2)
Funasaka T
(2)
Haga A
(2)
Korri-Youssoufi H
(2)
Lazar N
(2)
Li de la Sierra-Gallay I
(2)
Muirhead H
(2)
Nagase H
(2)
Nakamura KT
(2)
Plancqueel S
(2)
Raz A
(2)
Salmon L
(2)
Tanaka N
(2)
Uemura H
(2)
van Tilbeurgh H
(2)
Ban N
(1)
Bergstrom G
(1)
Bergström G
(1)
Cheng L
(1)
Cordeiro AT
(1)
Deuerling E
(1)
Diederichs K
(1)
Fernandez G
(1)
Forslind K
(1)
Gamerdinger M
(1)
Garratt RC
(1)
Ge C
(1)
Gjertsson I
(1)
Godoi PH
(1)
Godoi PHC
(1)
Holmdahl R
(1)
Hunaeus G
(1)
Jaskolowski M
(1)
Jia M
(1)
Johansson L
(1)
Jomaa A
(1)
Kastbom A
(1)
Khakzar KM
(1)
Kramer A
(1)
Krämer A
(1)
Leu Agelii M
(1)
Li Q
(1)
Li T
(1)
Li X
(1)
Lonnblom E
(1)
Lönnblom E
(1)
Oliva G
(1)
Pearce J
(1)
Rabl L
(1)
Rantapaa-Dahlqvist S
(1)
Rantapää-Dahlqvist S
(1)
Read J
(1)
Read JA
(1)
Sareila O
(1)
Scaiola A
(1)
Schloemer R
(1)
Silva CH
(1)
Silva CHTP
(1)
Thiemann OH
(1)
Ulusoy Z
(1)
Wallisch A
(1)
Xu B
(1)
Yang M
(1)
Homo / hetero assembly
(2)
homo
(11)
hetero
(2)
Assembly composition
(3)
protein structure
(11)
RNA/protein complex
(1)
protein/protein complex
(1)
Assembly polymer count
(3)
dimer
(11)
88-mer
(1)
trimer
(1)
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(7)
2.0 - 2.5
(3)
2.5 - 3
(2)
Release year distribution
2000 - 2005
(5)
2015 - 2020
(2)
2020 - 2025
(8)
2025 - 2030
(4)
Journal
(7)
FEBS J
(4)
J Mol Biol
(3)
Bioorg Chem
(2)
Acta Crystallogr D Biol Crystallogr
(1)
Ann Rheum Dis
(1)
Biochim Biophys Acta
(1)
Science
(1)
Macromolecules
Organism superkingdom
(1)
Eukaryota
(13)
Organism name
(2)
Homo sapiens
(12)
Oryctolagus cuniculus
(1)
Molecule name
(12)
AMF
(13)
Autocrine motility factor
(13)
GPI
(13)
Glucose-6-phosphate isomerase
(13)
NLK
(13)
Neuroleukin
(13)
PGI
(13)
PHI
(13)
Phosphoglucose isomerase
(13)
Phosphohexose isomerase
(13)
SA-36
(13)
Sperm antigen 36
(13)
Molecule type
(1)
Protein
(13)
Gene names
(1)
GPI
(13)
Interacting Molecules
(89)
18s rRNA
(1)
28S ribosomal RNA
(1)
40S ribosomal protein S24
(1)
40S ribosomal protein S26
(1)
5.8S ribosomal RNA
(1)
5S ribosomal RNA
(1)
E-site tRNA
(1)
Heavy Chain of TL1 Fab fragment
(1)
Large ribosomal subunit protein eL13
(1)
Large ribosomal subunit protein eL14
(1)
Large ribosomal subunit protein eL15
(1)
Large ribosomal subunit protein eL19
(1)
Large ribosomal subunit protein eL20
(1)
Large ribosomal subunit protein eL21
(1)
Large ribosomal subunit protein eL22
(1)
Large ribosomal subunit protein eL24
(1)
Large ribosomal subunit protein eL27
(1)
Large ribosomal subunit protein eL28
(1)
Large ribosomal subunit protein eL29
(1)
Large ribosomal subunit protein eL30
(1)
Large ribosomal subunit protein eL31
(1)
Large ribosomal subunit protein eL32
(1)
Large ribosomal subunit protein eL33
(1)
Large ribosomal subunit protein eL34
(1)
Large ribosomal subunit protein eL36
(1)
Large ribosomal subunit protein eL37
(1)
Large ribosomal subunit protein eL38
(1)
Large ribosomal subunit protein eL39
(1)
Large ribosomal subunit protein eL42
(1)
Large ribosomal subunit protein eL43
(1)
Large ribosomal subunit protein eL6
(1)
Large ribosomal subunit protein eL8
(1)
Large ribosomal subunit protein uL1
(1)
Large ribosomal subunit protein uL10
(1)
Large ribosomal subunit protein uL11
(1)
Large ribosomal subunit protein uL13
(1)
Large ribosomal subunit protein uL14
(1)
Large ribosomal subunit protein uL15
(1)
Large ribosomal subunit protein uL15/eL18 domain-containing protein
(1)
Large ribosomal subunit protein uL16
(1)
Large ribosomal subunit protein uL18
(1)
Large ribosomal subunit protein uL2
(1)
Large ribosomal subunit protein uL22
(1)
Large ribosomal subunit protein uL23
(1)
Large ribosomal subunit protein uL24
(1)
Large ribosomal subunit protein uL29
(1)
Large ribosomal subunit protein uL3
(1)
Large ribosomal subunit protein uL30
(1)
Large ribosomal subunit protein uL4
(1)
Large ribosomal subunit protein uL5
(1)
Large ribosomal subunit protein uL6
(1)
Light Chain of TL1 Fab fragment
(1)
Methionine aminopeptidase 1
(1)
Nascent polypeptide-associated complex subunit alpha
(1)
P-site Val-tRNA
(1)
Small ribosomal subunit protein RACK1
(1)
Small ribosomal subunit protein eS1
(1)
Small ribosomal subunit protein eS10
(1)
Small ribosomal subunit protein eS12
(1)
Small ribosomal subunit protein eS17
(1)
Small ribosomal subunit protein eS19
(1)
Small ribosomal subunit protein eS21
(1)
Small ribosomal subunit protein eS25
(1)
Small ribosomal subunit protein eS27
(1)
Small ribosomal subunit protein eS28
(1)
Small ribosomal subunit protein eS32
(1)
Small ribosomal subunit protein eS4
(1)
Small ribosomal subunit protein eS6
(1)
Small ribosomal subunit protein eS7
(1)
Small ribosomal subunit protein eS8
(1)
Small ribosomal subunit protein uS10
(1)
Small ribosomal subunit protein uS11
(1)
Small ribosomal subunit protein uS12
(1)
Small ribosomal subunit protein uS13
(1)
Small ribosomal subunit protein uS14
(1)
Small ribosomal subunit protein uS15
(1)
Small ribosomal subunit protein uS17
(1)
Small ribosomal subunit protein uS19
(1)
Small ribosomal subunit protein uS2
(1)
Small ribosomal subunit protein uS3
(1)
Small ribosomal subunit protein uS4
(1)
Small ribosomal subunit protein uS5
(1)
Small ribosomal subunit protein uS7
(1)
Small ribosomal subunit protein uS8
(1)
Small ribosomal subunit protein uS9
(1)
Transcription factor BTF3
(1)
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
(1)
Ubiquitin-ribosomal protein eL40 fusion protein
(1)
Ubiquitin-ribosomal protein eS31 fusion protein
(1)
Interacting ligands
(16)
PA5 : 5-PHOSPHOARABINONIC ACID
(3)
PGE : TRIETHYLENE GLYCOL
(3)
BME : BETA-MERCAPTOETHANOL
(2)
PEG : DI(HYDROXYETHYL)ETHER
(2)
PG4 : TETRAETHYLENE GLYCOL
(2)
SO4 : SULFATE ION
(2)
TRS : 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
(2)
13P : 1,3-DIHYDROXYACETONEPHOSPHATE
(1)
1PE : PENTAETHYLENE GLYCOL
(1)
CIZ : (~{Z})-2-methylbut-2-enedioic acid
(1)
E4P : ERYTHOSE-4-PHOSPHATE
(1)
GOL : GLYCEROL
(1)
MAE : MALEIC ACID
(1)
O1B : (2R,3R,4S)-5-((2-aminoethyl)amino)-2,3,4-trihydroxy-5-oxopentyl dihydrogen phosphate
(1)
PEP : PHOSPHOENOLPYRUVATE
(1)
PG6 : 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE
(1)
Function and Biology
EC number / name
(1)
5.3.1.9 : Glucose-6-phosphate isomerase
(13)
Biological function
(8)
carbohydrate derivative binding
(8)
cytokine activity
(7)
glucose-6-phosphate isomerase activity
(7)
growth factor activity
(7)
isomerase activity
(7)
monosaccharide binding
(7)
protein binding
(7)
ubiquitin protein ligase binding
(7)
Biological process
(24)
carbohydrate derivative metabolic process
(8)
canonical glycolysis
(7)
carbohydrate metabolic process
(7)
erythrocyte homeostasis
(7)
fructose 6-phosphate metabolic process
(7)
gluconeogenesis
(7)
glucose 6-phosphate metabolic process
(7)
glucose homeostasis
(7)
glycolytic process
(7)
hemostasis
(7)
humoral immune response
(7)
in utero embryonic development
(7)
learning or memory
(7)
mesoderm formation
(7)
negative regulation of apoptotic process
(7)
positive regulation of endothelial cell migration
(7)
positive regulation of immunoglobulin production
(7)
response to cadmium ion
(7)
response to estradiol
(7)
response to immobilization stress
(7)
response to muscle stretch
(7)
response to progesterone
(7)
response to testosterone
(7)
signal transduction
(7)
Biological cell component
(10)
ciliary membrane
(7)
cytoplasm
(7)
cytosol
(7)
extracellular exosome
(7)
extracellular region
(7)
extracellular space
(7)
ficolin-1-rich granule lumen
(7)
membrane
(7)
plasma membrane
(7)
secretory granule lumen
(7)
Sequence and Structure classification
SCOP fold
(1)
SIS domain
(5)
SCOP family
(1)
Phosphoglucose isomerase, PGI
(5)
CATH class
(2)
Alpha Beta
(5)
Mainly Alpha
(5)
CATH topology
(2)
Phosphoglucose isomerase, C-terminal domain
(5)
Rossmann fold
(5)
Pfam accession / name
(1)
PF00342 : PGI
(11)
Experimental Information
Diffraction protocol
(1)
Single wavelength
(12)
Diffraction radiation source type
(2)
Synchrotron
(11)
Rotating anode
(1)
Diffraction source
(8)
MAX IV BEAMLINE BioMAX
(5)
LNLS BEAMLINE D03B-MX1
(1)
PHOTON FACTORY BEAMLINE BL-18B
(1)
PHOTON FACTORY BEAMLINE BL-6A
(1)
RIGAKU RU300
(1)
SOLEIL BEAMLINE PROXIMA 1
(1)
SOLEIL BEAMLINE PROXIMA 2
(1)
SRS BEAMLINE PX7.2
(1)
Synchrotron site
(5)
MAX IV
(5)
Photon Factory
(2)
SOLEIL
(2)
LNLS
(1)
SRS
(1)
Diffraction detector type
(3)
Pixel
(7)
Image plate
(3)
CCD
(2)
Refinement software
(4)
REFMAC
(11)
PHENIX
(5)
CNS
(1)
phenix.real_space_refine
(1)
EM microscope model
(1)
FEI TITAN KRIOS
(1)
EM detector name
(1)
GATAN K3 (6k x 4k)
(1)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 13
Select all entries on this page
The crystal structure of a mouse Fab fragment TL1 in complex with a human Glucose-6-phosphate isomerase peptide 293-307
Ge C, Holmdahl R, Li T
Ann Rheum Dis
(2023)
[PMID: 36858822 ]
Source organisms: Mus musculus , Homo sapiens
Assembly composition: protein/protein complex
Modified residues:
ACA
Assembly name:
Glucose-6-phosphate isomerase and IG-heavy chain and IG-light kappa chain
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-272371 (Preferred)
search this ID

Crystal structure of human Glucose-6-phosphate isomerase with dihydroxyacetone phosphate ligand
Jonatansdottir YY, Hjorleifsson GJ
FEBS J
(2025)
[PMID: 40014465 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Glucose-6-phosphate isomerase
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-139198 (Preferred)
search this ID

Crystal structure of human Glucose-6-phosphate isomerase with citraconate ligand
Jonatansdottir YY, Hjorleifsson GJ
FEBS J
(2025)
[PMID: 40014465 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Glucose-6-phosphate isomerase
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-139198 (Preferred)
search this ID

Crystal structure of human Glucose-6-phosphate isomerase with maleate ligand
Jonatansdottir YY, Hjorleifsson GJ
FEBS J
(2025)
[PMID: 40014465 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Glucose-6-phosphate isomerase
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-139198 (Preferred)
search this ID

Crystal structure of human Glucose-6-phosphate isomerase with phosphoenol pyruvate ligand
Jonatansdottir YY, Hjorleifsson GJ
FEBS J
(2025)
[PMID: 40014465 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Glucose-6-phosphate isomerase
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-139198 (Preferred)
search this ID

Crystal structure of human phosphoglucose isomerase in complex with inhibitor
Li de la Sierra-Gallay I, Ahmad L, Plancqueel S, van Tilbeurgh H, Salmon L
Bioorg Chem
(2020)
[PMID: 32682158 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Glucose-6-phosphate isomerase
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-139198 (Preferred)
search this ID

Ternary complex of translating ribosome, NAC and METAP1
Jia M, Jaskolowski M, Scaiola A, Jomaa A, Ban N
Science
(2023)
[PMID: 37347872 ]
Source organisms: Oryctolagus cuniculus , Homo sapiens
Assembly composition: RNA/protein complex
Modified residues:
4AC
A2M
AME
B8N
M3L
MLZ
OMC
OMG
UY1
5MC
6MZ
HIC
N
OMU
SAC
UY1
5F0
G7M
5MC
G7M
HY3
HY3
UR3
4AC
5MU
5MU
6MZ
A2M
MA6
N
SAC
1MA
AYA
HIC
MLZ
NMM
V5N
1MA
AYA
M3L
NMM
PSU
PSU
AME
MA6
OMC
OMG
OMU
UR3
PDBe complex ID:
PDB-CPX-268539 (Preferred)
search this ID
Human Glucose-6-phosphate Isomerase
Cordeiro AT
Biochim Biophys Acta
(2003)
[PMID: 12573240 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Glucose-6-phosphate isomerase
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-139198 (Preferred)
search this ID

Crystal structure of human autocrine motility factor complexed with an inhibitor
Tanaka N, Haga A, Uemura H, Akiyama H, Funasaka T, Nagase H, Raz A, Nakamura KT
J Mol Biol
(2002)
[PMID: 12054796 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Glucose-6-phosphate isomerase
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-139198 (Preferred)
search this ID

The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate
Davies C
Acta Crystallogr D Biol Crystallogr
(2003)
[PMID: 12777791 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Glucose-6-phosphate isomerase
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-139198 (Preferred)
search this ID

Entries 1 to 10 of 13