Entry status  (1)

REL

(3)

Experimental methods  (1)

Electron Microscopy

(3)

Authors  (24)

Christopoulos A

(3)

Sexton PM

(3)

Wootten D

(3)

Belousoff MJ

(2)

Cao J

(2)

Danev R

(2)

Hay DL

(2)

Liang YL

(2)

Baumeister W

(1)

Deganutti G

(1)

Garama DJ

(1)

Glukhova A

(1)

Gregory KJ

(1)

Josephs TM

(1)

Khoshouei M

(1)

Koole C

(1)

Leach K

(1)

Miller LJ

(1)

Peat TS

(1)

Piper SJ

(1)

Plitzko JM

(1)

Radjainia M

(1)

Reynolds CA

(1)

Wootten DL

(1)

Homo / hetero assembly  (1)

hetero

(3)

Assembly composition  (1)

protein/protein complex

(3)

Assembly polymer count  (2)

heptamer

(2)

trimer

(1)

Resolution distribution

2.0 - 2.5

(1)

3.0 - 3.5

(2)

Release year distribution

2015 - 2020

(1)

2020 - 2025

(2)

Journal  (3)

Biochemistry

(1)

Nature

(1)

Science

(1)

Organism superkingdom  (1)

Eukaryota

(3)

Organism name  (1)

Homo sapiens

(3)

Molecule name  (20)

Alpha-type CGRP

(3)

CGRP-I

(3)

CGRP1

(3)

CRLR activity-modifying protein 1

(3)

Calcitonin gene-related peptide 1

(3)

Calcitonin gene-related peptide I

(3)

Calcitonin-receptor-like receptor activity-modifying protein 1

(3)

Receptor activity-modifying protein 1

(3)

Adenylate cyclase-stimulating G alpha protein

(2)

CGRP type 1 receptor

(2)

CRLR

(2)

Calcitonin gene-related peptide type 1 receptor

(2)

Calcitonin receptor-like receptor

(2)

G gamma-I

(2)

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

(2)

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

(2)

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

(2)

Transducin beta chain 1

(2)

CT-R

(1)

Calcitonin receptor

(1)

Molecule type  (1)

Protein

(3)

Gene names  (11)

CALC1

(3)

CALCA

(3)

RAMP1

(3)

CALCRL

(2)

CGRPR

(2)

GNAS

(2)

GNAS1

(2)

GNB1

(2)

GNG2

(2)

GSP

(2)

CALCR

(1)

Interacting Molecules  (8)

Calcitonin gene-related peptide 1

(3)

Receptor activity-modifying protein 1

(3)

Calcitonin gene-related peptide type 1 receptor

(2)

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

(2)

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

(2)

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

(2)

Nanobody 35

(2)

Calcitonin receptor

(1)

Interacting ligands  (3)

NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose

(1)

PLM : PALMITIC ACID

(1)

Y01 : CHOLESTEROL HEMISUCCINATE

(1)

Biological function  (26)

G protein-coupled receptor activity

(3)

amylin receptor activity

(3)

calcitonin gene-related peptide binding

(3)

calcitonin gene-related peptide receptor activity

(3)

calcitonin receptor activity

(3)

coreceptor activity

(3)

hormone activity

(3)

protein binding

(3)

transmembrane signaling receptor activity

(3)

D1 dopamine receptor binding

(2)

G protein activity

(2)

G-protein beta-subunit binding

(2)

G-protein beta/gamma-subunit complex binding

(2)

GTP binding

(2)

GTPase activity

(2)

GTPase binding

(2)

adenylate cyclase activator activity

(2)

guanyl nucleotide binding

(2)

hydrolase activity

(2)

metal ion binding

(2)

nucleotide binding

(2)

protein-containing complex binding

(2)

signaling receptor complex adaptor activity

(2)

amyloid-beta binding

(1)

calcitonin binding

(1)

calcitonin family receptor activity

(1)

Biological process  (57)

G protein-coupled receptor signaling pathway

(3)

adenylate cyclase-activating G protein-coupled receptor signaling pathway

(3)

amylin receptor 1 signaling pathway

(3)

amylin receptor signaling pathway

(3)

angiogenesis

(3)

calcitonin gene-related peptide receptor signaling pathway

(3)

calcium ion transport

(3)

cell surface receptor signaling pathway

(3)

cellular response to hormone stimulus

(3)

intracellular protein transport

(3)

positive regulation of protein glycosylation

(3)

protein localization to plasma membrane

(3)

protein transport

(3)

receptor internalization

(3)

regulation of G protein-coupled receptor signaling pathway

(3)

G protein-coupled acetylcholine receptor signaling pathway

(2)

Ras protein signal transduction

(2)

activation of adenylate cyclase activity

(2)

adenylate cyclase-activating adrenergic receptor signaling pathway

(2)

adenylate cyclase-activating dopamine receptor signaling pathway

(2)

bone development

(2)

cell population proliferation

(2)

cellular response to catecholamine stimulus

(2)

cellular response to glucagon stimulus

(2)

cellular response to prostaglandin E stimulus

(2)

cognition

(2)

developmental growth

(2)

fibroblast proliferation

(2)

hair follicle placode formation

(2)

intracellular transport

(2)

negative regulation of inflammatory response to antigenic stimulus

(2)

phospholipase C-activating G protein-coupled receptor signaling pathway

(2)

platelet aggregation

(2)

positive regulation of cold-induced thermogenesis

(2)

regulation of insulin secretion

(2)

renal water homeostasis

(2)

retina development in camera-type eye

(2)

sensory perception of smell

(2)

sensory perception of taste

(2)

signal transduction

(2)

vascular endothelial cell response to laminar fluid shear stress

(2)

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

(1)

amylin receptor 2 signaling pathway

(1)

amylin receptor 3 signaling pathway

(1)

calcitonin family receptor signaling pathway

(1)

negative regulation of ossification

(1)

ossification

(1)

osteoclast differentiation

(1)

positive regulation of ERK1 and ERK2 cascade

(1)

positive regulation of cAMP/PKA signal transduction

(1)

positive regulation of calcium-mediated signaling

(1)

positive regulation of cytosolic calcium ion concentration

(1)

positive regulation of gene expression

(1)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

(1)

regulation of mRNA stability

(1)

response to amyloid-beta

(1)

response to glucocorticoid

(1)

Biological cell component  (22)

CGRP receptor complex

(3)

cell surface

(3)

extracellular region

(3)

membrane

(3)

plasma membrane

(3)

receptor complex

(3)

cytoplasm

(2)

cytosol

(2)

extracellular exosome

(2)

extracellular vesicle

(2)

heterotrimeric G-protein complex

(2)

lysosomal membrane

(2)

photoreceptor disc membrane

(2)

photoreceptor outer segment

(2)

synapse

(2)

trans-Golgi network membrane

(2)

acrosomal vesicle

(1)

amylin receptor complex 1

(1)

amylin receptor complex 2

(1)

amylin receptor complex 3

(1)

axon

(1)

cilium

(1)

CATH class  (2)

Few Secondary Structures

(1)

Mainly Beta

(1)

CATH topology  (2)

G Protein Gi Gamma 2

(1)

Methylamine Dehydrogenase; Chain H

(1)

Pfam accession / name  (6)

PF00002 : 7tm_2

(3)

PF02793 : HRM

(3)

PF04901 : RAMP

(3)

PF00400 : WD40

(2)

PF00503 : G-alpha

(2)

PF00631 : G-gamma

(2)

Refinement software  (1)

PHENIX

(1)

EM microscope model  (2)

TFS KRIOS

(2)

FEI TITAN KRIOS

(1)

EM detector name  (2)

GATAN K3 BIOQUANTUM (6k x 4k)

(2)

GATAN K2 SUMMIT (4k x 4k)

(1)

Representative Structures

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