Uniprot accession / id : P09036  OR   Uniprot accession / id : P00995
 
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Entry Information
Entry status  (1)
REL
(5)
 
Experimental methods  (1)
X-ray diffraction
(5)
 
Authors  (14)
Collins J
(3)
Hecht HJ
(3)
Schomburg D
(3)
Szardenings M
(3)
Delcea M
(2)
Geist N
(2)
Girbardt B
(2)
Lammers M
(2)
Lerch MM
(2)
Mayerle J
(2)
McDonnell TCR
(2)
Nagel F
(2)
Palm GJ
(2)
Susemihl A
(2)
 
Homo / hetero assembly  (2)
hetero
(4)
homo
(1)
 
Assembly composition  (2)
protein/protein complex
(4)
protein structure
(1)
 
Assembly polymer count  (2)
dimer
(4)
monomer
(1)
 
Resolution distribution
2.0 - 2.5
(4)
2.5 - 3
(1)
 
Release year distribution
1990 - 1995
(3)
2020 - 2025
(2)
 
Journal  (2)
J Mol Biol
(3)
Int J Mol Sci
(2)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(5)
 
Organism name  (1)
Homo sapiens
(5)
 
Molecule name  (4)
Pancreatic secretory trypsin inhibitor
(5)
Serine protease inhibitor Kazal-type 1
(5)
TATI
(5)
Tumor-associated trypsin inhibitor
(5)
 
Molecule type  (1)
Protein
(5)
 
Gene names  (2)
PSTI
(5)
SPINK1
(5)
 
Interacting Molecules  (2)
Chymotrypsinogen A
(2)
Serine protease 1
(2)
 
Interacting ligands  (1)
SO4 : SULFATE ION
(2)
 
Function and Biology
Biological function  (4)
endopeptidase inhibitor activity
(5)
peptidase inhibitor activity
(5)
protein binding
(5)
serine-type endopeptidase inhibitor activity
(5)
 
Biological process  (6)
negative regulation of calcium ion import
(5)
negative regulation of nitric oxide mediated signal transduction
(5)
nitric oxide mediated signal transduction
(5)
regulation of acrosome reaction
(5)
regulation of store-operated calcium entry
(5)
sperm capacitation
(5)
 
Biological cell component  (3)
extracellular exosome
(5)
extracellular region
(5)
extracellular space
(5)
 
Sequence and Structure classification
SCOP fold  (1)
Kazal-type serine protease inhibitors
(3)
 
SCOP family  (1)
Ovomucoid domain III-like
(3)
 
CATH class  (1)
Alpha Beta
(3)
 
CATH topology  (1)
Wheat Germ Agglutinin (Isolectin 2); domain 1
(3)
 
Pfam accession / name  (1)
PF00050 : Kazal_1
(5)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(2)
 
Diffraction radiation source type  (1)
Synchrotron
(2)
 
Diffraction source  (2)
BESSY BEAMLINE 14.1
(1)
BESSY BEAMLINE 14.2
(1)
 
Synchrotron site  (1)
BESSY
(2)
 
Diffraction detector type  (1)
Pixel
(2)
 
Refinement software  (4)
PROLSQ
(2)
PHENIX
(1)
REFMAC
(1)
X-PLOR
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 5 of 5
Entries 1 to 5 of 5
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Human cationic trypsin (TRY1) complexed with serine protease inhibitor Kazal type 1 N34S (SPINK1 N34S)
Nagel F, Palm GJ, Delcea M, Lammers M
Int J Mol Sci (2022) [PMID: 35408828  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Serine protease 1 and Serine protease inhibitor Kazal-type 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133771 (Preferred)   search this ID
PDBe-KB: P00995    P07477   
X-ray diffraction
2.1Å resolution
Released: 30 Mar 2022
Model geometry
Fit model/data
7qe9
7qe9
7qe9
Human cationic trypsin (TRY1) complexed with serine protease inhibitor Kazal type 1 (SPINK1)
Nagel F, Palm GJ, Delcea M, Lammers M
Int J Mol Sci (2022) [PMID: 35408828  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Serine protease 1 and Serine protease inhibitor Kazal-type 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133771 (Preferred)   search this ID
PDBe-KB: P00995    P07477   
X-ray diffraction
2.9Å resolution
Released: 30 Mar 2022
Model geometry
Fit model/data
7qe8
7qe8
7qe8
THREE-DIMENSIONAL STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN*A AND TWO RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL-TYPE)
Hecht HJ, Szardenings M, Collins J, Schomburg D
J Mol Biol (1991) [PMID: 1870127  ]
Source organisms: Bos taurus  , Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Serine protease inhibitor Kazal-type 1 and Chymotrypsin A chain C (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133429 (Preferred)   search this ID
PDBe-KB: P00995    P00766   
X-ray diffraction
2.3Å resolution
Released: 31 Oct 1993
Model geometry
Fit model/data
1cgi
1cgi
1cgi
THREE-DIMENSIONAL STRUCTURE OF A RECOMBINANT VARIANT OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL TYPE)
Hecht HJ, Szardenings M, Collins J, Schomburg D
J Mol Biol (1992) [PMID: 1613792  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Serine protease inhibitor Kazal-type 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133770 (Preferred)   search this ID
PDBe-KB: P00995   
X-ray diffraction
2.3Å resolution
Released: 31 Oct 1993
Model geometry
Fit model/data
1hpt
1hpt
1hpt
THREE-DIMENSIONAL STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN*A AND TWO RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL-TYPE)
Hecht HJ, Szardenings M, Collins J, Schomburg D
J Mol Biol (1991) [PMID: 1870127  ]
Source organisms: Bos taurus  , Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Serine protease inhibitor Kazal-type 1 and Chymotrypsin A chain C (Preferred)   search this complex
PDBe complex ID: PDB-CPX-133429 (Preferred)   search this ID
PDBe-KB: P00995    P00766   
X-ray diffraction
2.3Å resolution
Released: 31 Oct 1993
Model geometry
Fit model/data
1cgj
1cgj
1cgj
Entries 1 to 5 of 5
Entries 1 to 5 of 5