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(1)
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(6)
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(1)
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(143)
Takagi J
(6)
Mihara E
(4)
Springer TA
(4)
Xia W
(4)
Campbell MG
(3)
Nguyen A
(3)
Arimori T
(2)
Azumaya CM
(2)
Biertumpfel C
(2)
Biertümpfel C
(2)
Cabanas C
(2)
Cabañas C
(2)
Chan MC
(2)
Charlesworth C
(2)
Cordara G
(2)
Dedden D
(2)
Heim JB
(2)
Hytonen VP
(2)
Hytönen VP
(2)
Johannesen H
(2)
Krengel U
(2)
Li J
(2)
Li M
(2)
Madden B
(2)
Matoba K
(2)
Meves A
(2)
Miyazaki N
(2)
Mizuno N
(2)
Mykuliak VV
(2)
Nagae M
(2)
Nogi T
(2)
Nunez RV
(2)
Re S
(2)
Schumacher S
(2)
Sekiguchi K
(2)
Sidibe A
(2)
Sidibé A
(2)
Sugita Y
(2)
Takizawa M
(2)
Taniguchi Y
(2)
Vazquez Nunez R
(2)
Wehrle-Haller B
(2)
Wu J
(2)
Wu JH
(2)
Zhang P
(2)
Zhang PF
(2)
Alamo KAE
(1)
Anthis NJ
(1)
Bai M
(1)
Baker D
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Balakrishna D
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Bate N
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Bigi-Botterill SV
(1)
Boggon TJ
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Brizuela-Velasco A
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Cabrerizo-Aguado D
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Calderwood DA
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Carney DW
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Chambers A
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Chen CH
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Cooper JA
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Critchley DR
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DeForest CA
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DeMent K
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Deng Y
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Dougan DR
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Draheim K
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Ermolieff J
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Estrada Alamo KA
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Flick AC
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Flum J
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Fullenwider C
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Gerben S
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Gibson TS
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Ginebra MP
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Ginsberg MH
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Goult BT
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Guillem-Marti J
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Hao Y
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Hernandez-Torres G
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Hsu VW
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Huang B
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Ivetac T
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Jennings A
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Johnson LK
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Kopyeva I
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Kumar S
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Kwok L
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Lane W
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Lee DS
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Li H
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Li X
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Lin J
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Lindsey EA
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Liu J
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More...
Homo / hetero assembly
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hetero
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homo
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(18)
protein structure
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(6)
dimer
(6)
tetramer
(5)
trimer
(5)
monomer
(2)
pentamer
(2)
nonamer
(1)
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1.5 - 2
(2)
2.0 - 2.5
(7)
2.5 - 3
(7)
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(2)
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(1)
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(1)
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2005 - 2010
(1)
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(8)
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2020 - 2025
(11)
2025 - 2030
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Proc Natl Acad Sci U S A
(5)
bioRxiv
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(2)
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iScience
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ACS Chem Neurosci
(1)
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Macromolecules
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(1)
Eukaryota
(21)
Organism name
(2)
Homo sapiens
(18)
Mus musculus
(3)
Molecule name
(11)
Fibronectin receptor subunit beta
(21)
Integrin beta-1
(21)
VLA-4 subunit beta
(21)
GPIIA
(18)
Glycoprotein IIa
(18)
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
(1)
Centaurin-beta-1
(1)
Cnt-b1
(1)
Fermitin family homolog 2
(1)
Kindlin-2
(1)
Pleckstrin homology domain-containing family C member 1
(1)
Molecule type
(1)
Protein
(21)
Gene names
(10)
FNRB
(18)
ITGB1
(18)
MDF2
(18)
MSK12
(18)
Itgb1
(3)
ACAP1
(1)
CENTB1
(1)
Fermt2
(1)
KIAA0050
(1)
Plekhc1
(1)
Interacting Molecules
(25)
Integrin alpha-5 heavy chain
(6)
Integrin alpha-5
(5)
Fermitin family homolog 2
(2)
Integrin alpha-6 heavy chain
(2)
SG/19 Fab fragment (Heavy chain)
(2)
SG/19 Fab fragment (Light chain)
(2)
Serine/threonine-protein kinase 4 18kDa subunit
(2)
ALA-CYS-ARG-GLY-ASP-GLY-TRP-CYS
(1)
ARG-GLY-ASP
(1)
BIIG2 Fab Heavy Chain
(1)
BIIG2 Fab Light Chain
(1)
GLY-ARG-GLY-ASP-SER-PRO
(1)
Integrin alpha-V heavy chain
(1)
Integrin beta-1-binding protein 1
(1)
Laminin subunit alpha-5
(1)
Laminin subunit beta-1
(1)
Laminin subunit gamma-1
(1)
MINT1526A Fab Heavy Chain
(1)
MINT1526A Fab Light Chain
(1)
NeoNectin
(1)
RGD peptide
(1)
TS2/16 VH(S112C)-SARAH Chimera
(1)
TS2/16 VL-SARAH(S37C) Chimera
(1)
Talin-2
(1)
Ugl-Y3
(1)
Interacting ligands
(10)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(14)
CA : CALCIUM ION
(11)
MG : MAGNESIUM ION
(8)
BMA : beta-D-mannopyranose
(6)
MN : MANGANESE (II) ION
(3)
MAN : alpha-D-mannopyranose
(2)
A1AFA : N-(2,4-dichlorobenzoyl)-L-phenylalanine
(1)
GOL : GLYCEROL
(1)
SO4 : SULFATE ION
(1)
ZN : ZINC ION
(1)
Function and Biology
Biological function
(22)
C-X3-C chemokine binding
(2)
actin binding
(2)
cadherin binding
(2)
calcium ion binding
(2)
cell adhesion molecule binding
(2)
collagen binding involved in cell-matrix adhesion
(2)
coreceptor activity
(2)
fibronectin binding
(2)
integrin binding
(2)
integrin binding involved in cell-matrix adhesion
(2)
laminin binding
(2)
magnesium ion binding
(2)
metal ion binding
(2)
protease binding
(2)
protein binding
(2)
protein heterodimerization activity
(2)
protein kinase binding
(2)
protein tyrosine kinase binding
(2)
protein-containing complex binding
(2)
signaling receptor activity
(2)
virus receptor activity
(2)
GTPase activator activity
(1)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 21
Select all entries on this page
Solution NMR structure of Integrin beta-1 TMD
Muhle-Goll C, Moser C
ACS Chem Neurosci
(2024)
[PMID: 38525994 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Integrin beta-1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-272340 (Preferred)
search this ID

Structure of alpha6beta1 integrin in complex with laminin-511
Arimori T, Miyazaki N, Takagi J
Nat Commun
(2021)
[PMID: 34188035 ]
Source organisms: Mus musculus , Homo sapiens
Assembly composition: protein/protein complex
Carbohydrate polymer components:
Molecule 1 -
NAG(2)
Assembly name:
Laminin-511 complex
(Preferred)
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PDBe complex ID:
PDB-CPX-279330 (Preferred)
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Crystal structure of alpha6beta1 integrin headpiece
Arimori T, Takagi J
Nat Commun
(2021)
[PMID: 34188035 ]
Source organisms: Mus musculus , Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Integrin alpha6-beta1 complex and Serine/threonine-protein kinase 4 18kDa subunit
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-138716 (Preferred)
search this ID
Structural basis of kindlin-mediated integrin recognition and activation
Li H, Yang H, Sun K, Zhang Z, Yu C, Wei Z
Proc Natl Acad Sci U S A
(2017)
[PMID: 28739949 ]
Source organism: Mus musculus
Assembly composition: protein only structure
Bound ligands:
GOL
Assembly name:
Fermitin family homolog 2, Integrin beta-1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-140545 (Preferred)
search this ID
Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin
Werther R, Nguyen A, Estrada Alamo KA, Wang X, Campbell MG
bioRxiv
(2024)
[PMID: 38979380 ]
Source organisms: synthetic construct , Homo sapiens
Assembly composition: protein/protein complex
Carbohydrate polymer components:
Molecule 1 -
BMA(1), NAG(2)
Molecule 2 -
NAG(2)
Molecule 3 -
BMA(1), MAN(3), NAG(2)
Assembly name:
Integrin alpha5-beta1 complex and unmapped proteins
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-272341 (Preferred)
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Crystal structure of alpha-V beta-1 integrin headpiece in complex with TR01225179
Qin L, Lane W
J Med Chem
(2024)
[PMID: 38872300 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Carbohydrate polymer components:
Molecule 1 -
BMA(1), NAG(2)
Molecule 2 -
BMA(1), MAN(3), NAG(2)
Assembly name:
Integrin alphav-beta1 complex
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-283464 (Preferred)
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Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation
Schumacher S, Dedden D, Vazquez Nunez R, Matoba K, Takagi J, Biertumpfel C, Mizuno N
Sci Adv
(2021)
[PMID: 33962943 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Carbohydrate polymer components:
Molecule 1 -
BMA(1), NAG(2)
Molecule 2 -
BMA(1), MAN(1), NAG(2)
Molecule 3 -
NAG(2)
Molecule 4 -
BMA(1), MAN(2), NAG(3)
Assembly name:
Integrin alpha5-beta1 complex
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-138710 (Preferred)
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Integrin alpha-5 beta-1 in complex with MINT1526A Fab
Nguyen A, Azumaya CM, Campbell MG
bioRxiv
(2025)
[PMID: 39829743 ]
Source organisms: unidentified , Homo sapiens
Assembly composition: protein/protein complex
Carbohydrate polymer components:
Molecule 1 -
BMA(1), NAG(2)
Molecule 2 -
BMA(1), MAN(4), NAG(2)
Molecule 3 -
BMA(1), MAN(1), NAG(2)
Molecule 4 -
NAG(2)
Assembly name:
Integrin alpha5-beta1 complex and antibody
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-284901 (Preferred)
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Integrin alpha-5 beta-1 in complex with BIIG2 Fab
Nguyen A, Azumaya CM, Campbell MG
bioRxiv
(2025)
[PMID: 39829743 ]
Source organisms: Rattus norvegicus , Homo sapiens
Assembly composition: protein/protein complex
Carbohydrate polymer components:
Molecule 1 -
BMA(1), NAG(2)
Molecule 2 -
BMA(1), MAN(3), NAG(2)
Molecule 3 -
NAG(2)
Molecule 4 -
BMA(1), MAN(1), NAG(2)
Assembly name:
Integrin alpha5-beta1 complex and antibody
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-284900 (Preferred)
search this ID
Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp
Schumacher S, Dedden D, Vazquez Nunez R, Matoba K, Takagi J, Biertumpfel C, Mizuno N
Sci Adv
(2021)
[PMID: 33962943 ]
Source organisms: Mus musculus , Homo sapiens
Assembly composition: protein/protein complex
Carbohydrate polymer components:
Molecule 1 -
BMA(1), NAG(2)
Molecule 2 -
NAG(2)
Molecule 3 -
BMA(1), MAN(2), NAG(2)
Molecule 4 -
BMA(1), MAN(2), NAG(3)
Molecule 5 -
BMA(1), MAN(1), NAG(2)
Assembly name:
Integrin alpha5-beta1 complex and Fibronectin
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-208783 (Preferred)
search this ID
Entries 1 to 10 of 21