Uniprot accession / id : P09055  OR   Uniprot accession / id : P05556  OR   Uniprot accession / id : C9JNE0
 
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Entry Information
Entry status  (1)
REL
(21)
 
Experimental methods  (3)
X-ray diffraction
(14)
Electron Microscopy
(6)
Solution NMR
(1)
 
Authors  (143)
Takagi J
(6)
Mihara E
(4)
Springer TA
(4)
Xia W
(4)
Campbell MG
(3)
Nguyen A
(3)
Arimori T
(2)
Azumaya CM
(2)
Biertumpfel C
(2)
Biertümpfel C
(2)
Cabanas C
(2)
Cabañas C
(2)
Chan MC
(2)
Charlesworth C
(2)
Cordara G
(2)
Dedden D
(2)
Heim JB
(2)
Hytonen VP
(2)
Hytönen VP
(2)
Johannesen H
(2)
Krengel U
(2)
Li J
(2)
Li M
(2)
Madden B
(2)
Matoba K
(2)
Meves A
(2)
Miyazaki N
(2)
Mizuno N
(2)
Mykuliak VV
(2)
Nagae M
(2)
Nogi T
(2)
Nunez RV
(2)
Re S
(2)
Schumacher S
(2)
Sekiguchi K
(2)
Sidibe A
(2)
Sidibé A
(2)
Sugita Y
(2)
Takizawa M
(2)
Taniguchi Y
(2)
Vazquez Nunez R
(2)
Wehrle-Haller B
(2)
Wu J
(2)
Wu JH
(2)
Zhang P
(2)
Zhang PF
(2)
Alamo KAE
(1)
Anthis NJ
(1)
Bai M
(1)
Baker D
(1)
Balakrishna D
(1)
Bate N
(1)
Bigi-Botterill SV
(1)
Boggon TJ
(1)
Brizuela-Velasco A
(1)
Cabrerizo-Aguado D
(1)
Calderwood DA
(1)
Campbell ID
(1)
Carney DW
(1)
Chambers A
(1)
Chen CH
(1)
Cooper JA
(1)
Critchley DR
(1)
DeForest CA
(1)
DeMent K
(1)
Deng Y
(1)
Dougan DR
(1)
Draheim K
(1)
Draheim KM
(1)
Ermolieff J
(1)
Estrada Alamo KA
(1)
Flick AC
(1)
Flum J
(1)
Fullenwider C
(1)
Gerben S
(1)
Gibson TS
(1)
Ginebra MP
(1)
Ginsberg MH
(1)
Goult BT
(1)
Guillem-Marti J
(1)
Guschtschin-Schmidt N
(1)
Hao Y
(1)
Hernandez-Torres G
(1)
Hsu VW
(1)
Huang B
(1)
Ivetac T
(1)
Jennings A
(1)
Johns D
(1)
Johnson LK
(1)
Kim C
(1)
Kopyeva I
(1)
Kumar S
(1)
Kwok L
(1)
Lane W
(1)
Lee DS
(1)
Li H
(1)
Li X
(1)
Lin J
(1)
Lindsey EA
(1)
Liu J
(1)
 
More...
 
Homo / hetero assembly  (2)
hetero
(18)
homo
(3)
 
Assembly composition  (2)
protein/protein complex
(18)
protein structure
(3)
 
Assembly polymer count  (6)
dimer
(6)
tetramer
(5)
trimer
(5)
monomer
(2)
pentamer
(2)
nonamer
(1)
 
Resolution distribution
1.5 - 2
(2)
2.0 - 2.5
(7)
2.5 - 3
(7)
3.0 - 3.5
(2)
3.5 - 4
(1)
4.5 - 5
(1)
 
Release year distribution
2005 - 2010
(1)
2010 - 2015
(8)
2015 - 2020
(1)
2020 - 2025
(11)
2025 - 2030
(3)
 
Journal  (11)
Proc Natl Acad Sci U S A
(5)
bioRxiv
(3)
J Cell Biol
(2)
Nat Commun
(2)
Sci Adv
(2)
iScience
(2)
ACS Chem Neurosci
(1)
EMBO J
(1)
J Biol Chem
(1)
J Med Chem
(1)
Mol Cell
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(21)
 
Organism name  (2)
Homo sapiens
(18)
Mus musculus
(3)
 
Molecule name  (11)
Fibronectin receptor subunit beta
(21)
Integrin beta-1
(21)
VLA-4 subunit beta
(21)
GPIIA
(18)
Glycoprotein IIa
(18)
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
(1)
Centaurin-beta-1
(1)
Cnt-b1
(1)
Fermitin family homolog 2
(1)
Kindlin-2
(1)
Pleckstrin homology domain-containing family C member 1
(1)
 
Molecule type  (1)
Protein
(21)
 
Gene names  (10)
FNRB
(18)
ITGB1
(18)
MDF2
(18)
MSK12
(18)
Itgb1
(3)
ACAP1
(1)
CENTB1
(1)
Fermt2
(1)
KIAA0050
(1)
Plekhc1
(1)
 
Interacting Molecules  (25)
Integrin alpha-5 heavy chain
(6)
Integrin alpha-5
(5)
Fermitin family homolog 2
(2)
Integrin alpha-6 heavy chain
(2)
SG/19 Fab fragment (Heavy chain)
(2)
SG/19 Fab fragment (Light chain)
(2)
Serine/threonine-protein kinase 4 18kDa subunit
(2)
ALA-CYS-ARG-GLY-ASP-GLY-TRP-CYS
(1)
ARG-GLY-ASP
(1)
BIIG2 Fab Heavy Chain
(1)
BIIG2 Fab Light Chain
(1)
GLY-ARG-GLY-ASP-SER-PRO
(1)
Integrin alpha-V heavy chain
(1)
Integrin beta-1-binding protein 1
(1)
Laminin subunit alpha-5
(1)
Laminin subunit beta-1
(1)
Laminin subunit gamma-1
(1)
MINT1526A Fab Heavy Chain
(1)
MINT1526A Fab Light Chain
(1)
NeoNectin
(1)
RGD peptide
(1)
TS2/16 VH(S112C)-SARAH Chimera
(1)
TS2/16 VL-SARAH(S37C) Chimera
(1)
Talin-2
(1)
Ugl-Y3
(1)
 
Interacting ligands  (10)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(14)
CA : CALCIUM ION
(11)
MG : MAGNESIUM ION
(8)
BMA : beta-D-mannopyranose
(6)
MN : MANGANESE (II) ION
(3)
MAN : alpha-D-mannopyranose
(2)
A1AFA : N-(2,4-dichlorobenzoyl)-L-phenylalanine
(1)
GOL : GLYCEROL
(1)
SO4 : SULFATE ION
(1)
ZN : ZINC ION
(1)
 
Function and Biology
Biological function  (22)
C-X3-C chemokine binding
(2)
actin binding
(2)
cadherin binding
(2)
calcium ion binding
(2)
cell adhesion molecule binding
(2)
collagen binding involved in cell-matrix adhesion
(2)
coreceptor activity
(2)
fibronectin binding
(2)
integrin binding
(2)
integrin binding involved in cell-matrix adhesion
(2)
laminin binding
(2)
magnesium ion binding
(2)
metal ion binding
(2)
protease binding
(2)
protein binding
(2)
protein heterodimerization activity
(2)
protein kinase binding
(2)
protein tyrosine kinase binding
(2)
protein-containing complex binding
(2)
signaling receptor activity
(2)
virus receptor activity
(2)
GTPase activator activity
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 21
Entries 1 to 10 of 21
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Solution NMR structure of Integrin beta-1 TMD
Muhle-Goll C, Moser C
ACS Chem Neurosci (2024) [PMID: 38525994  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Integrin beta-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-272340 (Preferred)   search this ID
PDBe-KB: P05556   
Solution NMR
Released: 26 Jun 2024
Model geometry
Fit model/data
Data not deposited
8rpq
8rpq
8rpq
Structure of alpha6beta1 integrin in complex with laminin-511
Arimori T, Miyazaki N, Takagi J
Nat Commun (2021) [PMID: 34188035  ]
Assembly composition: protein/protein complex
Bound ligands: CA    NAG    CA    MN    MN    NAG   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Assembly name: Laminin-511 complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-279330 (Preferred)   search this ID
PDBe-KB: P05556    P11047    O15230    P07942    Q13043    P23229   
Electron Microscopy
3.9Å resolution
Released: 23 Jun 2021
Model geometry
Fit model/data
Data not analysed
7cec
7cec
7cec
Crystal structure of alpha6beta1 integrin headpiece
Arimori T, Takagi J
Nat Commun (2021) [PMID: 34188035  ]
Assembly composition: protein/protein complex
Bound ligands: CA    MG    NAG    CA    MG    NAG   
Assembly name: Integrin alpha6-beta1 complex and Serine/threonine-protein kinase 4 18kDa subunit (Preferred)   search this complex
PDBe complex ID: PDB-CPX-138716 (Preferred)   search this ID
PDBe-KB: P05556    Q13043    P23229   
X-ray diffraction
2.89Å resolution
Released: 23 Jun 2021
Model geometry
Fit model/data
7ceb
7ceb
7ceb
Structural basis of kindlin-mediated integrin recognition and activation
Li H, Yang H, Sun K, Zhang Z, Yu C, Wei Z
Proc Natl Acad Sci U S A (2017) [PMID: 28739949  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Bound ligands: GOL   
Assembly name: Fermitin family homolog 2, Integrin beta-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140545 (Preferred)   search this ID
PDBe-KB: Q8CIB5    P09055   
X-ray diffraction
2.75Å resolution
Released: 26 Jul 2017
Model geometry
Fit model/data
5xq0
5xq0
5xq0
Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin
Werther R, Nguyen A, Estrada Alamo KA, Wang X, Campbell MG
bioRxiv (2024) [PMID: 38979380  ]
Assembly composition: protein/protein complex
Bound ligands: CA    NAG    CA    MN    MN    NAG   
Carbohydrate polymer components:
Molecule 1 - BMA(1), NAG(2)
Molecule 2 - NAG(2)
Molecule 3 - BMA(1), MAN(3), NAG(2)
Assembly name: Integrin alpha5-beta1 complex and unmapped proteins (Preferred)   search this complex
PDBe complex ID: PDB-CPX-272341 (Preferred)   search this ID
PDBe-KB: P05556    P08648   
Electron Microscopy
3.19Å resolution
Released: 17 Jul 2024
Model geometry
Fit model/data
Data not analysed
9ckv
9ckv
9ckv
Crystal structure of alpha-V beta-1 integrin headpiece in complex with TR01225179
Qin L, Lane W
J Med Chem (2024) [PMID: 38872300  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CA    NAG    A1AFA    CA    NAG    A1AFA   
Carbohydrate polymer components:
Molecule 1 - BMA(1), NAG(2)
Molecule 2 - BMA(1), MAN(3), NAG(2)
Assembly name: Integrin alphav-beta1 complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-283464 (Preferred)   search this ID
PDBe-KB: P05556    P06756   
X-ray diffraction
2.45Å resolution
Released: 1 Jan 2025
Model geometry
Fit model/data
8w30
8w30
8w30
Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation
Schumacher S, Dedden D, Vazquez Nunez R, Matoba K, Takagi J, Biertumpfel C, Mizuno N
Sci Adv (2021) [PMID: 33962943  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CA    MG    NAG    CA    MG    NAG   
Carbohydrate polymer components:
Molecule 1 - BMA(1), NAG(2)
Molecule 2 - BMA(1), MAN(1), NAG(2)
Molecule 3 - NAG(2)
Molecule 4 - BMA(1), MAN(2), NAG(3)
Assembly name: Integrin alpha5-beta1 complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-138710 (Preferred)   search this ID
PDBe-KB: P05556    P08648   
Electron Microscopy
4.6Å resolution
Released: 25 Aug 2021
Model geometry
Fit model/data
Data not analysed
7nxd
7nxd
7nxd
Integrin alpha-5 beta-1 in complex with MINT1526A Fab
Nguyen A, Azumaya CM, Campbell MG
bioRxiv (2025) [PMID: 39829743  ]
Assembly composition: protein/protein complex
Bound ligands: CA    NAG    CA    NAG   
Carbohydrate polymer components:
Molecule 1 - BMA(1), NAG(2)
Molecule 2 - BMA(1), MAN(4), NAG(2)
Molecule 3 - BMA(1), MAN(1), NAG(2)
Molecule 4 - NAG(2)
Assembly name: Integrin alpha5-beta1 complex and antibody (Preferred)   search this complex
PDBe complex ID: PDB-CPX-284901 (Preferred)   search this ID
PDBe-KB: P05556    P08648   
Electron Microscopy
2.7Å resolution
Released: 5 Feb 2025
Model geometry
Fit model/data
Data not analysed
9b9k
9b9k
9b9k
Integrin alpha-5 beta-1 in complex with BIIG2 Fab
Nguyen A, Azumaya CM, Campbell MG
bioRxiv (2025) [PMID: 39829743  ]
Assembly composition: protein/protein complex
Bound ligands: CA    NAG    CA    NAG   
Carbohydrate polymer components:
Molecule 1 - BMA(1), NAG(2)
Molecule 2 - BMA(1), MAN(3), NAG(2)
Molecule 3 - NAG(2)
Molecule 4 - BMA(1), MAN(1), NAG(2)
Assembly name: Integrin alpha5-beta1 complex and antibody (Preferred)   search this complex
PDBe complex ID: PDB-CPX-284900 (Preferred)   search this ID
PDBe-KB: P05556    P08648   
Electron Microscopy
2.6Å resolution
Released: 5 Feb 2025
Model geometry
Fit model/data
Data not analysed
9b9j
9b9j
9b9j
Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp
Schumacher S, Dedden D, Vazquez Nunez R, Matoba K, Takagi J, Biertumpfel C, Mizuno N
Sci Adv (2021) [PMID: 33962943  ]
Assembly composition: protein/protein complex
Bound ligands: MN    MN   
Carbohydrate polymer components:
Molecule 1 - BMA(1), NAG(2)
Molecule 2 - NAG(2)
Molecule 3 - BMA(1), MAN(2), NAG(2)
Molecule 4 - BMA(1), MAN(2), NAG(3)
Molecule 5 - BMA(1), MAN(1), NAG(2)
Assembly name: Integrin alpha5-beta1 complex and Fibronectin (Preferred)   search this complex
PDBe complex ID: PDB-CPX-208783 (Preferred)   search this ID
PDBe-KB: P05556    P08648    P02751   
Electron Microscopy
3.1Å resolution
Released: 2 Jun 2021
Model geometry
Fit model/data
Data not analysed
7nwl
7nwl
7nwl
Entries 1 to 10 of 21
Entries 1 to 10 of 21