Uniprot accession / id : P0C605  OR   Uniprot accession / id : Q13976  OR   Uniprot accession / id : B1ALS0
 
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Entry Information
Entry status  (1)
REL
(26)
 
Experimental methods  (4)
X-ray diffraction
(25)
Hybrid
(1)
Neutron Diffraction
(1)
Solution NMR
(1)
 
Authors  (92)
Kim C
(19)
Sankaran B
(15)
Casteel DE
(12)
Herberg FW
(8)
Kim JJ
(8)
Qin L
(7)
Kim CW
(6)
Beaumont M
(5)
Cheng AC
(5)
Fischmann TO
(5)
Hanisak J
(5)
Henning P
(5)
Metwally E
(5)
Reger AS
(5)
Zebisch M
(5)
Zwart P
(5)
Baker JJ
(4)
Campbell JC
(4)
Ermakov G
(4)
Greshock T
(4)
Healy D
(4)
Huang GY
(4)
Lim Y-H
(4)
Mak V
(4)
McEwan P
(4)
Melacini G
(4)
Patel A
(4)
Rose Y
(4)
Silvestre L
(4)
Sylvestre HL
(4)
Brown NG
(3)
Casteel D
(3)
Chow DC
(3)
Franz E
(3)
Headd J
(3)
Headd JJ
(3)
Huang G
(3)
Kwon TH
(3)
Kwon TK
(3)
Lorenz R
(3)
Palzkill T
(3)
Ren RK
(3)
Akimoto M
(2)
Bertinetti D
(2)
Blakeley MP
(2)
Gerlits OO
(2)
Guo E
(2)
Kaur G
(2)
Kovalevsky AY
(2)
MacKenzie KR
(2)
Moon EW
(2)
Pflugrath JW
(2)
Selvaratnam R
(2)
Sharma R
(2)
VanSchouwen B
(2)
Vanschouwen B
(2)
Yang MP
(2)
Zhao C
(2)
Aminzai S
(1)
Arold ST
(1)
Bao J
(1)
Barker J
(1)
Berkeley Structural Genomics Center (BSGC)
(1)
Chou JJ
(1)
Ermakov GP
(1)
Fischmann T
(1)
Gerlits O
(1)
Greshock TJ
(1)
Healy DR
(1)
Kovalevsky A
(1)
Lim YH
(1)
Lying Q
(1)
Mak VW
(1)
McEwan PA
(1)
Ogawa A
(1)
Patel AM
(1)
Pilz RB
(1)
Rearden P
(1)
Ren Z
(1)
Rigby AC
(1)
Roh SH
(1)
Schnell JR
(1)
Seganish WM
(1)
Silvestre HL
(1)
Smith-Nguyen EV
(1)
Soriano A
(1)
Verras A
(1)
Yen R
(1)
Yu Y
(1)
Zheng R
(1)
Zhou GP
(1)
Zweckstetter M
(1)
 
Homo / hetero assembly  (1)
homo
(26)
 
Assembly composition  (1)
protein structure
(26)
 
Assembly polymer count  (2)
monomer
(17)
dimer
(9)
 
Resolution distribution
1.0 - 1.5
(6)
1.5 - 2
(8)
2.0 - 2.5
(9)
2.5 - 3
(2)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(2)
2010 - 2015
(10)
2015 - 2020
(10)
2020 - 2025
(7)
 
Journal  (10)
Biochemistry
(4)
Commun Biol
(4)
ACS Chem Biol
(3)
PLoS One
(3)
Structure
(3)
To be published
(3)
Elife
(2)
J Biol Chem
(2)
J Med Chem
(1)
Protein Sci
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(26)
 
Organism name  (1)
Homo sapiens
(26)
 
Molecule type  (1)
Protein
(26)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 26
Entries 1 to 10 of 26
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Crystal structure of human protein kinase G (PKG) R-C complex in inhibited state
Sharma R, Lying Q, Casteel D, Kim C
Elife (2022) [PMID: 35929723  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ANP    ANP    MN    MN    EDO   
Modified residues: TPO    TPO   
Assembly name: cGMP-dependent protein kinase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171845 (Preferred)   search this ID
PDBe-KB: Q13976    Q13976   
X-ray diffraction
2.41Å resolution
Released: 24 Aug 2022
Model geometry
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7lv3
7lv3
7lv3
PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-Br-cGMP
Campbell JC, Sankaran B, Kim CW
ACS Chem Biol (2017) [PMID: 28793191  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CA    CA    6J7    NA    6J7    NA   
Assembly name: cGMP-dependent protein kinase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171844 (Preferred)   search this ID
PDBe-KB: Q13976    Q13976   
X-ray diffraction
1.486Å resolution
Released: 19 Apr 2017
Model geometry
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5jax
5jax
5jax
PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-pCPT-cGMP
Campbell JC, Sankaran B, Kim CW
ACS Chem Biol (2017) [PMID: 28793191  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 6FW    CA    CA    NA    6FW    EDO    NA   
Assembly name: cGMP-dependent protein kinase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171844 (Preferred)   search this ID
PDBe-KB: Q13976    Q13976   
X-ray diffraction
1.49Å resolution
Released: 12 Apr 2017
Model geometry
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5j48
5j48
5j48
Crystal structure of cGMP-dependent protein kinase Ialpha (PKG Ialpha) catalytic domain bound with N46
Qin L, Sankaran B, Kim C
J Biol Chem (2018) [PMID: 29769318  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: EE4    EE4    DMS    DMS    PGE    PGE   
Modified residues: TPO    TPO   
Assembly name: cGMP-dependent protein kinase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171844 (Preferred)   search this ID
PDBe-KB: Q13976   
X-ray diffraction
1.98Å resolution
Released: 30 May 2018
Model geometry
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6c0t
6c0t
6c0t
PKG I's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with RP-cGMP
Campbell JC, Sankaran B, Kim CW
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: CA    CA    6ZA    6ZA    SO4    EDO   
Assembly name: cGMP-dependent protein kinase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171844 (Preferred)   search this ID
PDBe-KB: Q13976    Q13976   
X-ray diffraction
1.285Å resolution
Released: 2 Aug 2017
Model geometry
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5l0n
5l0n
5l0n
Crystal structure of cGMP-dependent protein kinase Ialpha (PKG Ialpha) catalytic domain in AMP-PNP bound state
Qin L, Sankaran B, Kim C
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ANP    ANP    MN    MN   
Modified residues: TPO    TPO   
Assembly name: cGMP-dependent protein kinase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171844 (Preferred)   search this ID
PDBe-KB: Q13976   
X-ray diffraction
1.83Å resolution
Released: 31 Oct 2018
Model geometry
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6bg2
6bg2
6bg2
Crystal Structure of cGMP-dependent Protein Kinase
Zebisch M, Silvestre L, Fischmann TO
Commun Biol (2023)
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: EX6    EX6   
Modified residues: TPO    TPO   
Assembly name: cGMP-dependent protein kinase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171844 (Preferred)   search this ID
PDBe-KB: Q13976   
X-ray diffraction
1.99Å resolution
Released: 14 Jun 2023
Model geometry
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7t4u
7t4u
7t4u
Co-structure of PKG1 regulatory domain with compound 33
Fischmann TO
J Med Chem (2022) [PMID: 35878399  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: B4I    B4I   
Assembly name: cGMP-dependent protein kinase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171844 (Preferred)   search this ID
PDBe-KB: Q13976    Q13976   
X-ray diffraction
1.4Å resolution
Released: 24 Aug 2022
Model geometry
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7ssb
7ssb
7ssb
Crystal Structure of cGMP-dependent Protein Kinase
Zebisch M, Silvestre L, Fischmann TO
Commun Biol (2023)
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: EXZ    EXZ    CL   
Modified residues: TPO    TPO   
Assembly name: cGMP-dependent protein kinase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171844 (Preferred)   search this ID
PDBe-KB: Q13976   
X-ray diffraction
2.28Å resolution
Released: 14 Jun 2023
Model geometry
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7t4v
7t4v
7t4v
Crystal Structure of cGMP-dependent Protein Kinase
Zebisch M, Silvestre L, Fischmann TO
Commun Biol (2023)
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PCG    ATP    CL    PCG    ATP    EDO   
Modified residues: TPO    TPO   
Assembly name: cGMP-dependent protein kinase 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-171844 (Preferred)   search this ID
PDBe-KB: Q13976   
X-ray diffraction
2.08Å resolution
Released: 14 Jun 2023
Model geometry
Fit model/data
7t4t
7t4t
7t4t
Entries 1 to 10 of 26
Entries 1 to 10 of 26