Entry status  (1)

REL

(9)

Experimental methods  (2)

X-ray diffraction

(7)

Solution NMR

(2)

Authors  (41)

De Vos AM

(4)

Ultsch M

(4)

de Vos AM

(3)

Arseniev AS

(2)

Bocharov EV

(2)

Bocharova OV

(2)

Efremov RG

(2)

Giebel LB

(2)

Kossiakoff AA

(2)

Lesovoy DM

(2)

Lundqvist T

(2)

Milligan D

(2)

Norstedt G

(2)

Pavlov KV

(2)

Rodin J

(2)

Rödin J

(2)

Sundstrom M

(2)

Sundstrom SM

(2)

Sundström M

(2)

Urban AS

(2)

Volynsky PE

(2)

Wells JA

(2)

Adams JJ

(1)

Atwell S

(1)

Brown RJ

(1)

Clackson T

(1)

Eidne KA

(1)

Kossiakoff A

(1)

McKinstry WJ

(1)

Monks TA

(1)

Palethorpe K

(1)

Parker MW

(1)

Pelekanos RA

(1)

Schiffer C

(1)

Schiffer CA

(1)

Seeber RM

(1)

Somers W

(1)

Ultsch MH

(1)

Walsh S

(1)

Wan Y

(1)

Waters MJ

(1)

Homo / hetero assembly  (2)

hetero

(6)

homo

(3)

Assembly composition  (2)

protein/protein complex

(6)

protein structure

(3)

Assembly polymer count  (4)

dimer

(3)

trimer

(3)

tetramer

(2)

monomer

(1)

Resolution distribution

2.0 - 2.5

(2)

2.5 - 3

(5)

Release year distribution

1990 - 1995

(1)

1995 - 2000

(4)

2000 - 2005

(2)

2005 - 2010

(1)

2015 - 2020

(2)

Journal  (5)

Biochim Biophys Acta Gen Subj

(2)

J Biol Chem

(2)

J Mol Biol

(2)

Science

(2)

Nat Struct Mol Biol

(1)

Organism superkingdom  (1)

Eukaryota

(9)

Organism name  (1)

Homo sapiens

(9)

Molecule name  (13)

GH receptor

(9)

GH-binding protein

(9)

GHBP

(9)

Growth hormone receptor

(9)

Growth hormone-binding protein

(9)

Serum-binding protein

(9)

Somatotropin receptor

(9)

GH

(6)

GH-N

(6)

Growth hormone

(6)

Growth hormone 1

(6)

Pituitary growth hormone

(6)

Somatotropin

(6)

Molecule type  (1)

Protein

(9)

Gene names  (2)

GHR

(9)

GH1

(6)

Interacting Molecules  (2)

Growth hormone-binding protein

(6)

Somatotropin

(6)

Interacting ligands  (1)

SO4 : SULFATE ION

(1)

Biological function  (9)

cytokine receptor activity

(7)

cytokine activity

(6)

growth factor activity

(6)

growth hormone activity

(6)

growth hormone receptor binding

(6)

hormone activity

(6)

metal ion binding

(6)

prolactin receptor binding

(6)

protein binding

(6)

Biological process  (16)

animal organ development

(6)

bone maturation

(6)

cell surface receptor signaling pathway via JAK-STAT

(6)

cell surface receptor signaling pathway via STAT

(6)

cytokine-mediated signaling pathway

(6)

growth hormone receptor signaling pathway

(6)

growth hormone receptor signaling pathway via JAK-STAT

(6)

positive regulation of D-glucose transmembrane transport

(6)

positive regulation of MAPK cascade

(6)

positive regulation of insulin-like growth factor receptor signaling pathway

(6)

positive regulation of multicellular organism growth

(6)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

(6)

positive regulation of receptor internalization

(6)

positive regulation of receptor signaling pathway via JAK-STAT

(6)

response to estradiol

(6)

response to nutrient levels

(6)

Biological cell component  (7)

membrane

(7)

collagen-containing extracellular matrix

(6)

endosome lumen

(6)

extracellular region

(6)

extracellular space

(6)

growth hormone receptor complex

(6)

vesicle

(6)

SCOP fold  (2)

Immunoglobulin-like beta-sandwich

(7)

4-helical cytokines

(6)

SCOP family  (2)

Fibronectin type III

(7)

Long-chain cytokines

(6)

CATH class  (2)

Mainly Beta

(7)

Mainly Alpha

(6)

CATH topology  (2)

Immunoglobulin-like

(7)

Growth Hormone; Chain: A;

(6)

Pfam accession / name  (3)

PF00041 : fn3

(7)

PF09067 : EpoR_lig-bind

(7)

PF00103 : Hormone_1

(6)

Diffraction protocol  (1)

Single wavelength

(2)

Diffraction radiation source type  (2)

Synchrotron

(3)

Rotating anode

(1)

Diffraction source  (4)

APS BEAMLINE 14-ID-B

(1)

CHESS BEAMLINE F1

(1)

RIGAKU RUH2R

(1)

SSRL BEAMLINE BL7-1

(1)

Synchrotron site  (3)

APS

(1)

CHESS

(1)

SSRL

(1)

Diffraction detector type  (3)

Image plate

(3)

CCD

(2)

Diffractometer

(1)

Refinement software  (3)

X-PLOR

(6)

CNS

(1)

REFMAC

(1)

NMR software packages  (5)

CARA

(2)

CYANA

(2)

Mathematica

(2)

MddNMR

(2)

TopSpin

(2)

NMR Field Strength

500.0 - 600

(2)

600.0 - 700

(2)

700.0 - 800

(2)

800.0 - 900

(2)

Representative Structures

100%

95%

90%

70%

50%

40%

30%